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B0KSB2

- LPXB_PSEPG

UniProt

B0KSB2 - LPXB_PSEPG

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, PputGB1_1159
Organism
Pseudomonas putida (strain GB-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPPUT76869:GIXB-1190-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:PputGB1_1159
OrganismiPseudomonas putida (strain GB-1)
Taxonomic identifieri76869 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002157: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000080281Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi76869.PputGB1_1159.

Structurei

3D structure databases

ProteinModelPortaliB0KSB2.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B0KSB2-1 [UniParc]FASTAAdd to Basket

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MAQLCVALVA GEASGDILGS GLMRALKARH PDVRFIGVGG PLMEAEGLQS    50
YFPMERLAVM GLVEVLGRLR ELLKRRKLLI QTLIDEKPDV FIGIDAPDFT 100
LNIELKLRQA GIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLLPFEARF 150
YEEQGVPVRF VGHPLADTIP LEADRSVARA ALGLGEGPIV ALMPGSRGGE 200
VGRLGALFLD AAEHLCQQVP GVRFVLPCAN AARRAQVEHM LEGRQLPLTL 250
LDGQSHQALA ACDAVLIASG TATLEALLYK RPMVVAYRLA PLTYWILKRL 300
VKSPYVSLPN LLAQRELVPE LLQDQATSQA LANTLAPLVR DGSQQTERFD 350
EIHRTLRRDA SNQAAEAVLA LLKDR 375
Length:375
Mass (Da):41,202
Last modified:March 18, 2008 - v1
Checksum:i22E826CAC4A2E1A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000926 Genomic DNA. Translation: ABY97067.1.
RefSeqiYP_001667403.1. NC_010322.1.

Genome annotation databases

EnsemblBacteriaiABY97067; ABY97067; PputGB1_1159.
GeneIDi5868919.
KEGGippg:PputGB1_1159.
PATRICi19929291. VBIPsePut76638_1165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000926 Genomic DNA. Translation: ABY97067.1 .
RefSeqi YP_001667403.1. NC_010322.1.

3D structure databases

ProteinModelPortali B0KSB2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 76869.PputGB1_1159.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY97067 ; ABY97067 ; PputGB1_1159 .
GeneIDi 5868919.
KEGGi ppg:PputGB1_1159.
PATRICi 19929291. VBIPsePut76638_1165.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PPUT76869:GIXB-1190-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-1.

Entry informationi

Entry nameiLPXB_PSEPG
AccessioniPrimary (citable) accession number: B0KSB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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