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B0KSB2

- LPXB_PSEPG

UniProt

B0KSB2 - LPXB_PSEPG

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas putida (strain GB-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPPUT76869:GIXB-1190-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:PputGB1_1159
    OrganismiPseudomonas putida (strain GB-1)
    Taxonomic identifieri76869 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002157: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Lipid-A-disaccharide synthasePRO_1000080281Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi76869.PputGB1_1159.

    Structurei

    3D structure databases

    ProteinModelPortaliB0KSB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0KSB2-1 [UniParc]FASTAAdd to Basket

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    MAQLCVALVA GEASGDILGS GLMRALKARH PDVRFIGVGG PLMEAEGLQS    50
    YFPMERLAVM GLVEVLGRLR ELLKRRKLLI QTLIDEKPDV FIGIDAPDFT 100
    LNIELKLRQA GIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLLPFEARF 150
    YEEQGVPVRF VGHPLADTIP LEADRSVARA ALGLGEGPIV ALMPGSRGGE 200
    VGRLGALFLD AAEHLCQQVP GVRFVLPCAN AARRAQVEHM LEGRQLPLTL 250
    LDGQSHQALA ACDAVLIASG TATLEALLYK RPMVVAYRLA PLTYWILKRL 300
    VKSPYVSLPN LLAQRELVPE LLQDQATSQA LANTLAPLVR DGSQQTERFD 350
    EIHRTLRRDA SNQAAEAVLA LLKDR 375
    Length:375
    Mass (Da):41,202
    Last modified:March 18, 2008 - v1
    Checksum:i22E826CAC4A2E1A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000926 Genomic DNA. Translation: ABY97067.1.
    RefSeqiYP_001667403.1. NC_010322.1.

    Genome annotation databases

    EnsemblBacteriaiABY97067; ABY97067; PputGB1_1159.
    GeneIDi5868919.
    KEGGippg:PputGB1_1159.
    PATRICi19929291. VBIPsePut76638_1165.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000926 Genomic DNA. Translation: ABY97067.1 .
    RefSeqi YP_001667403.1. NC_010322.1.

    3D structure databases

    ProteinModelPortali B0KSB2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 76869.PputGB1_1159.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY97067 ; ABY97067 ; PputGB1_1159 .
    GeneIDi 5868919.
    KEGGi ppg:PputGB1_1159.
    PATRICi 19929291. VBIPsePut76638_1165.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PPUT76869:GIXB-1190-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-1.

    Entry informationi

    Entry nameiLPXB_PSEPG
    AccessioniPrimary (citable) accession number: B0KSB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3