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B0KSB2

- LPXB_PSEPG

UniProt

B0KSB2 - LPXB_PSEPG

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas putida (strain GB-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPPUT76869:GIXB-1190-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:PputGB1_1159
OrganismiPseudomonas putida (strain GB-1)
Taxonomic identifieri76869 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002157: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Lipid-A-disaccharide synthasePRO_1000080281Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi76869.PputGB1_1159.

Structurei

3D structure databases

ProteinModelPortaliB0KSB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B0KSB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLCVALVA GEASGDILGS GLMRALKARH PDVRFIGVGG PLMEAEGLQS
60 70 80 90 100
YFPMERLAVM GLVEVLGRLR ELLKRRKLLI QTLIDEKPDV FIGIDAPDFT
110 120 130 140 150
LNIELKLRQA GIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLLPFEARF
160 170 180 190 200
YEEQGVPVRF VGHPLADTIP LEADRSVARA ALGLGEGPIV ALMPGSRGGE
210 220 230 240 250
VGRLGALFLD AAEHLCQQVP GVRFVLPCAN AARRAQVEHM LEGRQLPLTL
260 270 280 290 300
LDGQSHQALA ACDAVLIASG TATLEALLYK RPMVVAYRLA PLTYWILKRL
310 320 330 340 350
VKSPYVSLPN LLAQRELVPE LLQDQATSQA LANTLAPLVR DGSQQTERFD
360 370
EIHRTLRRDA SNQAAEAVLA LLKDR
Length:375
Mass (Da):41,202
Last modified:March 18, 2008 - v1
Checksum:i22E826CAC4A2E1A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000926 Genomic DNA. Translation: ABY97067.1.
RefSeqiYP_001667403.1. NC_010322.1.

Genome annotation databases

EnsemblBacteriaiABY97067; ABY97067; PputGB1_1159.
GeneIDi5868919.
KEGGippg:PputGB1_1159.
PATRICi19929291. VBIPsePut76638_1165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000926 Genomic DNA. Translation: ABY97067.1 .
RefSeqi YP_001667403.1. NC_010322.1.

3D structure databases

ProteinModelPortali B0KSB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 76869.PputGB1_1159.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY97067 ; ABY97067 ; PputGB1_1159 .
GeneIDi 5868919.
KEGGi ppg:PputGB1_1159.
PATRICi 19929291. VBIPsePut76638_1165.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PPUT76869:GIXB-1190-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-1.

Entry informationi

Entry nameiLPXB_PSEPG
AccessioniPrimary (citable) accession number: B0KSB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 18, 2008
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3