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B0KQJ5

- B0KQJ5_PSEPG

UniProt

B0KQJ5 - B0KQJ5_PSEPG

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Protein
Histidinol dehydrogenase
Gene
hisD, PputGB1_0973
Organism
Pseudomonas putida (strain GB-1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotationSAAS annotations

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotations

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361NAD By similarityUniRule annotation
Binding sitei197 – 1971NAD By similarityUniRule annotation
Binding sitei220 – 2201NAD By similarityUniRule annotation
Binding sitei243 – 2431Substrate By similarityUniRule annotation
Metal bindingi265 – 2651Zinc By similarityUniRule annotation
Binding sitei265 – 2651Substrate By similarityUniRule annotation
Metal bindingi268 – 2681Zinc By similarityUniRule annotation
Binding sitei268 – 2681Substrate By similarityUniRule annotation
Active sitei333 – 3331Proton acceptor By similarityUniRule annotation
Active sitei334 – 3341Proton acceptor By similarityUniRule annotation
Binding sitei334 – 3341Substrate By similarityUniRule annotation
Metal bindingi367 – 3671Zinc By similarityUniRule annotation
Binding sitei367 – 3671Substrate By similarityUniRule annotation
Binding sitei421 – 4211Substrate By similarityUniRule annotation
Metal bindingi426 – 4261Zinc By similarityUniRule annotation
Binding sitei426 – 4261Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotations, NADUniRule annotationSAAS annotations, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciPPUT76869:GIXB-1004-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PputGB1_0973Imported
OrganismiPseudomonas putida (strain GB-1)Imported
Taxonomic identifieri76869 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002157: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi76869.PputGB1_0973.

Structurei

3D structure databases

ProteinModelPortaliB0KQJ5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0KQJ5-1 [UniParc]FASTAAdd to Basket

« Hide

MTVSTAIARL NAADPDFARH LDHLLSWESV SDDAVNQRVL DIIKAVRERG    50
DAALVEFTQR FDGVDAKSIE DLILNRERLE LALTRITPIQ REALEKAANR 100
VRMYHERQKQ DSWQYTEADG TVLGQKVTPL DRAGLYVPGG KASYPSSVLM 150
NAIPAKVAGV AEVVMVVPTP RGEVNELVLA AACIAGVDRV FTVGGAQAVA 200
ALAYGTESVP QVDKIVGPGN IYVATAKRHV FGQVGIDMIA GPSEILVVCD 250
GQTDPDWIAM DLFSQAEHDE DAQAILVSPD AAFLDRVAAS IDKLMPTMER 300
AEIIEKSING RGALIQVRDM QQAMDVANRI APEHLELSVA DPQAWLPHIR 350
HAGAIFMGRH TSEALGDYCA GPNHVLPTSG TARFSSPLGV YDFQKRSSII 400
FCSEQGASEL GHTASVLARG ESLTAHARSA EYRILTQDKG N 441
Length:441
Mass (Da):47,678
Last modified:March 18, 2008 - v1
Checksum:iA2FA13FFCBF97561
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000926 Genomic DNA. Translation: ABY96883.1.
RefSeqiWP_012270669.1. NC_010322.1.
YP_001667219.1. NC_010322.1.

Genome annotation databases

EnsemblBacteriaiABY96883; ABY96883; PputGB1_0973.
GeneIDi5868733.
KEGGippg:PputGB1_0973.
PATRICi19928921. VBIPsePut76638_0980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000926 Genomic DNA. Translation: ABY96883.1 .
RefSeqi WP_012270669.1. NC_010322.1.
YP_001667219.1. NC_010322.1.

3D structure databases

ProteinModelPortali B0KQJ5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 76869.PputGB1_0973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY96883 ; ABY96883 ; PputGB1_0973 .
GeneIDi 5868733.
KEGGi ppg:PputGB1_0973.
PATRICi 19928921. VBIPsePut76638_0980.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PPUT76869:GIXB-1004-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-1Imported.

Entry informationi

Entry nameiB0KQJ5_PSEPG
AccessioniPrimary (citable) accession number: B0KQJ5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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