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B0KQJ5

- B0KQJ5_PSEPG

UniProt

B0KQJ5 - B0KQJ5_PSEPG

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pseudomonas putida (strain GB-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotationSAAS annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotation

Cofactori

Note: Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361NADUniRule annotation
Binding sitei197 – 1971NADUniRule annotation
Binding sitei220 – 2201NADUniRule annotation
Binding sitei243 – 2431SubstrateUniRule annotation
Metal bindingi265 – 2651ZincUniRule annotation
Binding sitei265 – 2651SubstrateUniRule annotation
Metal bindingi268 – 2681ZincUniRule annotation
Binding sitei268 – 2681SubstrateUniRule annotation
Active sitei333 – 3331Proton acceptorUniRule annotation
Active sitei334 – 3341Proton acceptorUniRule annotation
Binding sitei334 – 3341SubstrateUniRule annotation
Metal bindingi367 – 3671ZincUniRule annotation
Binding sitei367 – 3671SubstrateUniRule annotation
Binding sitei421 – 4211SubstrateUniRule annotation
Metal bindingi426 – 4261ZincUniRule annotation
Binding sitei426 – 4261SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciPPUT76869:GIXB-1004-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PputGB1_0973Imported
OrganismiPseudomonas putida (strain GB-1)Imported
Taxonomic identifieri76869 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002157: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi76869.PputGB1_0973.

Structurei

3D structure databases

ProteinModelPortaliB0KQJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0KQJ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVSTAIARL NAADPDFARH LDHLLSWESV SDDAVNQRVL DIIKAVRERG
60 70 80 90 100
DAALVEFTQR FDGVDAKSIE DLILNRERLE LALTRITPIQ REALEKAANR
110 120 130 140 150
VRMYHERQKQ DSWQYTEADG TVLGQKVTPL DRAGLYVPGG KASYPSSVLM
160 170 180 190 200
NAIPAKVAGV AEVVMVVPTP RGEVNELVLA AACIAGVDRV FTVGGAQAVA
210 220 230 240 250
ALAYGTESVP QVDKIVGPGN IYVATAKRHV FGQVGIDMIA GPSEILVVCD
260 270 280 290 300
GQTDPDWIAM DLFSQAEHDE DAQAILVSPD AAFLDRVAAS IDKLMPTMER
310 320 330 340 350
AEIIEKSING RGALIQVRDM QQAMDVANRI APEHLELSVA DPQAWLPHIR
360 370 380 390 400
HAGAIFMGRH TSEALGDYCA GPNHVLPTSG TARFSSPLGV YDFQKRSSII
410 420 430 440
FCSEQGASEL GHTASVLARG ESLTAHARSA EYRILTQDKG N
Length:441
Mass (Da):47,678
Last modified:March 18, 2008 - v1
Checksum:iA2FA13FFCBF97561
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000926 Genomic DNA. Translation: ABY96883.1.
RefSeqiWP_012270669.1. NC_010322.1.
YP_001667219.1. NC_010322.1.

Genome annotation databases

EnsemblBacteriaiABY96883; ABY96883; PputGB1_0973.
GeneIDi5868733.
KEGGippg:PputGB1_0973.
PATRICi19928921. VBIPsePut76638_0980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000926 Genomic DNA. Translation: ABY96883.1 .
RefSeqi WP_012270669.1. NC_010322.1.
YP_001667219.1. NC_010322.1.

3D structure databases

ProteinModelPortali B0KQJ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 76869.PputGB1_0973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY96883 ; ABY96883 ; PputGB1_0973 .
GeneIDi 5868733.
KEGGi ppg:PputGB1_0973.
PATRICi 19928921. VBIPsePut76638_0980.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PPUT76869:GIXB-1004-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-1Imported.

Entry informationi

Entry nameiB0KQJ5_PSEPG
AccessioniPrimary (citable) accession number: B0KQJ5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3