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Protein

Probable 5-dehydro-4-deoxyglucarate dehydratase

Gene

PputGB1_2317

Organism
Pseudomonas putida (strain GB-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2.UniRule annotation

Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable 5-dehydro-4-deoxyglucarate dehydratase (PputGB1_2317)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciPPUT76869:GIXB-2370-MONOMER.
UniPathwayiUPA00564; UER00628.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-dehydro-4-deoxyglucarate dehydrataseUniRule annotation (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
Gene namesi
Ordered Locus Names:PputGB1_2317
OrganismiPseudomonas putida (strain GB-1)
Taxonomic identifieri76869 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002157 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000831761 – 303Probable 5-dehydro-4-deoxyglucarate dehydrataseAdd BLAST303

Interactioni

Protein-protein interaction databases

STRINGi76869.PputGB1_2317.

Structurei

3D structure databases

ProteinModelPortaliB0KPL8.
SMRiB0KPL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105UVJ. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.

Family and domain databases

CDDicd00951. KDGDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiView protein in Pfam
PF00701. DHDPS. 1 hit.
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiView protein in SMART
SM01130. DHDPS. 1 hit.
TIGRFAMsiTIGR03249. KdgD. 1 hit.

Sequencei

Sequence statusi: Complete.

B0KPL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPQELKSIL SHGLLSFPVT DFNAQGDFNP AGYIKRLEWL APYGASALFA
60 70 80 90 100
AGGTGEFFSL AASEYSQVIK TAVDTCATSV PILAGVGGST RQAIEYAQEA
110 120 130 140 150
ERLGAKGLLL LPHYLTEASQ DGVAAHVEAV CKSVNIGVVV YNRNVCRLNA
160 170 180 190 200
DLLEKLAERC PNLIGYKDGL GDIELMVSIR RRLGERFSYL GGLPTAEVYA
210 220 230 240 250
AAYKALGVPV YSSAVFNFVP KTAMDFYSAI ARDDHAAVAK LIDDFFLPYL
260 270 280 290 300
DIRNRKAGYA VSIVKAGAKI AGYDAGPVRT PLTDLTAEEY EMLAALMDKM

GPQ
Length:303
Mass (Da):32,576
Last modified:March 18, 2008 - v1
Checksum:i85C7565588F8E464
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000926 Genomic DNA. Translation: ABY98218.1.
RefSeqiWP_012271964.1. NC_010322.1.

Genome annotation databases

EnsemblBacteriaiABY98218; ABY98218; PputGB1_2317.
KEGGippg:PputGB1_2317.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKDGD_PSEPG
AccessioniPrimary (citable) accession number: B0KPL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 18, 2008
Last modified: June 7, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families