Reviewed, UniProtKB/Swiss-Prot B0KN18 (BETB_PSEPG)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	PputGB1_5114

Organism

Pseudomonas putida (strain GB-1) [Complete proteome] [HAMAP]

Taxonomic identifier

76869 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase		PRO_1000083710
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0KN18-1 [UniParc]. Last modified March 18, 2008. Version 1. Checksum: 90281237A7E278D9	FASTA	490	53,041
	10 20 30 40 50 60 MARFGTQKLY IDGAYVDAGS DATFEAINPA TGEVLAHVQR ATEADVEKAV ESAERGQKVW 70 80 90 100 110 120 AAMTAMQRSR ILRRAVDILR ERNDELAQLE TLDTGKSYSE TRYVDIVTGA DVLEYYAGLV 130 140 150 160 170 180 PAIEGEQIPL RESSFVYTRR EPLGVTVGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TSLTTLKLAE IYTEAGLPNG VFNVLTGSGR EVGTWLTEHP RIEKVSFTGG TTTGKKVMAS 250 260 270 280 290 300 ASSSSLKEVT MELGGKSPLI ICADADLDKA ADIAMMANFY SSGQVCTNGT RVFIPAEMKA 310 320 330 340 350 360 AFEAKIAERV ARIRVGNPED ENTNFGPLVS FAHMENVLSY IAKGKEEGAR VLCGGERLTE 370 380 390 400 410 420 GEFAKGAFVA PTVFTDCSDD MTIVKEEIFG PVMSILSYET EEEVIRRAND TEYGLAAGVC 430 440 450 460 470 480 TNDITRAHRI IHKLEAGICW INAWGESPAE MPVGGYKQSG VGRENGVSSL AQYTRIKSVQ 490 VELGGYNSVF

References

[1]

"Complete sequence of Pseudomonas putida GB-1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., McCarthy J.K., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000926 Genomic DNA. Translation: ABZ00999.1.
RefSeq	YP_001671334.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5872929.
GenomeReviews	Gene locus PputGB1_5114 in contig CP000926_GR.
KEGG	ppg:PputGB1_5114.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR011264. Betaine_Ald_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_PSEPG

Accession

Primary (citable) accession number: B0KN18

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 18, 2008
Last modified:	November 4, 2008
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)