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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Pseudomonas putida (strain GB-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciPPUT76869:G1GAZ-5063-MONOMER
UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:PputGB1_4924
OrganismiPseudomonas putida (strain GB-1)
Taxonomic identifieri76869 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002157 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000823261 – 401Nicotinate phosphoribosyltransferaseAdd BLAST401

Interactioni

Protein-protein interaction databases

STRINGi76869.PputGB1_4924

Structurei

3D structure databases

ProteinModelPortaliB0KKX3
SMRiB0KKX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

B0KKX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESAFAERI VHNLLDTDFY KLTMMQGVLH NYPDADVEWE FRCRNGEDLR
60 70 80 90 100
PYLGEIRNQL ERLNDLTLDD GQLPFLERIS FLKPDFLRFL RLFRFNLRYV
110 120 130 140 150
RVGIENDQLF LRLKGPWLHV ILFEVPLLAI ISEVRNRQLH PHMRLAEARD
160 170 180 190 200
QLYRKFDWLR AHASDEELAE LQVADFGTRR RFSSRVQEEV VRVLRDDFPA
210 220 230 240 250
RFVGTSNVDL AWKLDIKPLG TMAHEWIMAH QQLGPRLIDS QIAALDCWVR
260 270 280 290 300
EYRGLLGIAL TDCITMDAFL GDFDLYFAKL FDGLRHDSGE PVAWAEKAIA
310 320 330 340 350
HYQKLGIDPM TKTLVFSDGL NLTRSLEIFR ALRGRINVSF GIGTNLTCDI
360 370 380 390 400
PGVAPMSIVL KMTDCNGAPV AKISDEAAKT QCRDENFVAY MRHVFKVPSK

E
Length:401
Mass (Da):46,349
Last modified:March 18, 2008 - v1
Checksum:i813E41598AF7DF64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000926 Genomic DNA Translation: ABZ00809.1
RefSeqiWP_012274438.1, NC_010322.1

Genome annotation databases

EnsemblBacteriaiABZ00809; ABZ00809; PputGB1_4924
KEGGippg:PputGB1_4924

Similar proteinsi

Entry informationi

Entry nameiPNCB_PSEPG
AccessioniPrimary (citable) accession number: B0KKX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 18, 2008
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health