pgi

Functionⁱ

Catalytic activityⁱ

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayⁱ: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

no protein annotated in this organism
Glucose-6-phosphate isomerase (pgi)
no protein annotated in this organism
no protein annotated in this organism

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	359	Proton donorUniRule annotation	1
Active siteⁱ	390	UniRule annotation	1
Active siteⁱ	518	UniRule annotation	1

GO - Molecular functionⁱ

glucose-6-phosphate isomerase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-UniPathway
glycolytic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181. UPA00138.

UniPathwayⁱ

UPA00109; UER00181.
UPA00138.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation) Short name: GPIUniRule annotation Alternative name(s): Phosphoglucose isomeraseUniRule annotation Short name: PGIUniRule annotation Phosphohexose isomeraseUniRule annotation Short name: PHIUniRule annotation
Gene namesⁱ	Name:pgiUniRule annotation Ordered Locus Names:PputGB1_4700
Organismⁱ	Pseudomonas putida (strain GB-1)
Taxonomic identifierⁱ	76869 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas putida group › Pseudomonas putida
Proteomesⁱ	UP000002157 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00473

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000081245	1 – 554	Glucose-6-phosphate isomeraseAdd BLAST		554

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	76869.PputGB1_4700.

STRINGⁱ

76869.PputGB1_4700.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B0KHW6.
SMRⁱ	B0KHW6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4107QP8. Bacteria. COG0166. LUCA.
HOGENOMⁱ	HOG000261370.
KEGG Orthology (KO) More...KOⁱ	K01810.
OMAⁱ	TNSQHAF.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015. SIS_PGI_1. 1 hit. cd05016. SIS_PGI_2. 1 hit.
Gene3Dⁱ	1.10.1390.10. 1 hit.
HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	View protein in InterPro IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. IPR035476. SIS_PGI_1. IPR035482. SIS_PGI_2.
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342. PGI. 1 hit.
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B0KHW6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAYYRTPHDV TALPAWQALQ QHRDAMQGFS MREAFAADAQ RFDQFSLSCC 
        60         70         80         90        100
GLFLDYSKNL ITEQSRDLLV NLANEVGLQD AIKSMFAGEI INASEGRPVL 
       110        120        130        140        150
HTALRRPVGD KLSVNGVNVM PEVHKVLNQI TELVGRIHDG LWRGYSEKPI 
       160        170        180        190        200
TDVVNIGIGG SFLGPELVSE ALLPYAQRGV RCHYLANIDG SEFHELSANL 
       210        220        230        240        250
RAETTLFIVS SKSFNTLETL KNAMAARTWY LAQGGSEAEL YRHFIAVSSN 
       260        270        280        290        300
KAAAVAFGIR EENIFPMWDW VGGRYSLWSA IGLPIALAIG TANFKELLSG 
       310        320        330        340        350
AYTMDQHFQT APFDKNMPVL LALLGVWYGN FWGANSHAIL PYDHYLRNIT 
       360        370        380        390        400
KHLQQLDMES NGKSVLQDGT PVKTDTGPVI WGGVGCNGQH AYHQLLHQGT 
       410        420        430        440        450
QLIPADFIVP VVSFNPVADH HQWLYANCLS QSQALMLGKT REEAEAELRG 
       460        470        480        490        500
KGLNEADIEK LAPHKVIPGN RPSNTLVVER ISPRRLGALV AMYEHKVFVQ 
       510        520        530        540        550
SVIWGINAFD QWGVELGKEL GKGVYQRLVG SLEESAEDGS TQGLINYFRG 

RHRG

Length:554

Mass (Da):61,383

Last modified:March 18, 2008 - v1

Checksum:ⁱ07D99624F3460D66

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000926 Genomic DNA. Translation: ABZ00587.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012274232.1. NC_010322.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABZ00587; ABZ00587; PputGB1_4700.
KEGGⁱ	ppg:PputGB1_4700.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
B0KHW6	Q1I4P0 A0A1X7E2E6 UPI0009ECBBF5 UPI0004852E20 I3UR09 UPI00076163B4 UPI0002E3715B UPI0008636B57 UPI0003716990 I7CAN5 +118	Pseudomonas entomophila (strain L48) Pseudomonas sp. URMO17WK12:I5 Pseudomonas sp. NBRC 111121 Pseudomonas Pseudomonas putida ND6 Pseudomonas sp. GTC 16482 Pseudomonas putida (Arthrobacter siderocapsulatus) Pseudomonas sp. GTC 16473 Pseudomonas putida (strain DOT-T1E) Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) And more	554	UniRef90_Q1I4P0	Cluster: Glucose-6-phosphate isomerase	129

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
B0KHW6	Q1I4P0 A0A1X7E2E6 UPI0009ECBBF5 UPI0004852E20 I3UR09 UPI00076163B4 UPI0002E3715B UPI0008636B57 UPI0003716990 I7CAN5 +195	Pseudomonas entomophila (strain L48) Pseudomonas sp. URMO17WK12:I5 Pseudomonas sp. NBRC 111121 Pseudomonas Pseudomonas putida ND6 Pseudomonas sp. GTC 16482 Pseudomonas putida (Arthrobacter siderocapsulatus) Pseudomonas sp. GTC 16473 Pseudomonas putida (strain DOT-T1E) Pseudomonas sp. NBRC 111133 And more	554	UniRef50_Q1I4P0	Cluster: Glucose-6-phosphate isomerase	206

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000926 Genomic DNA. Translation: ABZ00587.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012274232.1. NC_010322.1.

3D structure databases

ProteinModelPortalⁱ	B0KHW6.
SMRⁱ	B0KHW6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	76869.PputGB1_4700.

STRINGⁱ

76869.PputGB1_4700.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABZ00587; ABZ00587; PputGB1_4700.
KEGGⁱ	ppg:PputGB1_4700.

Phylogenomic databases

eggNOGⁱ	ENOG4107QP8. Bacteria. COG0166. LUCA.
HOGENOMⁱ	HOG000261370.
KEGG Orthology (KO) More...KOⁱ	K01810.
OMAⁱ	TNSQHAF.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181. UPA00138.

UniPathwayⁱ

UPA00109; UER00181.
UPA00138.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05015. SIS_PGI_1. 1 hit. cd05016. SIS_PGI_2. 1 hit.
Gene3Dⁱ	1.10.1390.10. 1 hit.
HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	View protein in InterPro IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. IPR035476. SIS_PGI_1. IPR035482. SIS_PGI_2.
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342. PGI. 1 hit.
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G6PI_PSEPG
Accessionⁱ	B0KHW6Primary (citable) accession number: B0KHW6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
	Last sequence update:	March 18, 2008
	Last modified:	August 30, 2017
	This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B0KHW6 (G6PI_PSEPG)

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Glucose-6-phosphate isomerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: gluconeogenesis

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ