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B0KCW3 (MTLD_THEP3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:Teth39_1939
OrganismThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum) [Complete proteome] [HAMAP]
Taxonomic identifier340099 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Thermoanaerobacter

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000099207

Regions

Nucleotide binding4 – 1512NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B0KCW3 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: 6D50269AA36E401C

FASTA38844,487
        10         20         30         40         50         60 
MLKAVHFGAG NIGRGFIGYL LYKSGYEITF VDISKELVES INNYKRYNVI ILKDNVEKEE 

        70         80         90        100        110        120 
VKNIKAIHIE DEENLSKAIV DADIITTSVG ANNLKSIGEK LRNYLKIRKA NIDKPLNIMA 

       130        140        150        160        170        180 
CENALFATNI LKNSILEKGD KDFIEYVNQK IGFPNTAVDR IVPNVDIKKE LPIDVAVEDF 

       190        200        210        220        230        240 
YEWDIEKKAI IGDLNIKGAE LVDDLEPYIE RKLFLLNGAH ATTAYLGYLK GYKYIHEAIQ 

       250        260        270        280        290        300 
DDFIRNIVSK MQEEASIALS KKHNIKIDNL REYSNKVIKR FKNSYLKDEV VRVGREPTRK 

       310        320        330        340        350        360 
LSGNDRLMMP AKLCYEIGIT PKFILYGIAA GFLFDYKEDP QACKIQDDIK NFGLEKTISK 

       370        380 
ITGLEENSDL LHEIVKKYKE LKETFRKR

« Hide

References

[1]"Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33223 / 39E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000924 Genomic DNA. Translation: ABY95570.1.
RefSeqYP_001665906.1. NC_010321.1.

3D structure databases

ProteinModelPortalB0KCW3.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0KCW3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5873394.
GenomeReviewsGene locus Teth39_1939 in contig CP000924_GR.
KEGGtpd:Teth39_1939.
PATRIC23888689. VBIThePse6203_2033.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG568825.
OMAMACENAL.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycTPSE340099:TETH39_1939-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_THEP3
AccessionPrimary (citable) accession number: B0KCW3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 18, 2008
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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