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B0KC36

- FTHS_THEP3

UniProt

B0KC36 - FTHS_THEP3

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Teth39_0303
Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPSE340099:GH4W-310-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Teth39_0303
OrganismiThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Taxonomic identifieri340099 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002156: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000146706Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340099.Teth39_0303.

Structurei

3D structure databases

ProteinModelPortaliB0KC36.
SMRiB0KC36. Positions 4-553.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0KC36-1 [UniParc]FASTAAdd to Basket

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MKSDIEIAQE AKMLHIREVA KKLDIEEDYL EYYGKYKAKI SPALSEKIKD    50
RKDGKLILVT AITPTPAGEG KTTLTVGLGQ ALAKIGKKAM IALREPSLGP 100
CMGIKGGAAG GGYSQVVPME DINLHFTGDL HAITAAHNLL AAMIDNHIHH 150
GNELNIDIRA ITWKRAMDMN DRALREIIVG LGGKANGFPR QDGFIITVAS 200
EVMAILCLAQ DLMDLKRRIG DIIVAYDKDG NPVTARDLKA DGAMTVLLKD 250
AIKPNLVQTI ENVPAFVHGG PFANIAHGCN SLIATKYGLK LADYLVTEAG 300
FGADLGAEKF FDIKSRFGGL TPNAAVIVAT VKALKMHGGV KKEHLQKEDV 350
EAVRRGIENL EKQVENVRKF GVPVVVALNR FVFDTEREIE EVRKACEEMG 400
VDMAVAEVWE KGGEGGIELA EKVVKACETP SNFHVLYDET LPIKDKLHII 450
ATEIYGADGV EYTASALKDI ANLERLGFDK MPIVVAKTQY SLSDDPKLLG 500
RPRGFKITVR ELRVSRGAGF IVALTGDIMT MPGLPKHPAA ENIDIDENGR 550
ITGLF 555
Length:555
Mass (Da):60,349
Last modified:March 18, 2008 - v1
Checksum:iFE053937AE11690F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000924 Genomic DNA. Translation: ABY93972.1.
RefSeqiYP_001664308.1. NC_010321.1.

Genome annotation databases

EnsemblBacteriaiABY93972; ABY93972; Teth39_0303.
GeneIDi5874250.
KEGGitpd:Teth39_0303.
PATRICi23885169. VBIThePse6203_0323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000924 Genomic DNA. Translation: ABY93972.1 .
RefSeqi YP_001664308.1. NC_010321.1.

3D structure databases

ProteinModelPortali B0KC36.
SMRi B0KC36. Positions 4-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340099.Teth39_0303.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY93972 ; ABY93972 ; Teth39_0303 .
GeneIDi 5874250.
KEGGi tpd:Teth39_0303.
PATRICi 23885169. VBIThePse6203_0323.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci TPSE340099:GH4W-310-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33223 / 39E.

Entry informationi

Entry nameiFTHS_THEP3
AccessioniPrimary (citable) accession number: B0KC36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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