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Protein

8-amino-7-oxononanoate synthase

Gene

Teth39_0287

Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.By similarity

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].

Cofactori

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateBy similarity1
Binding sitei136SubstrateBy similarity1
Binding sitei184Pyridoxal phosphateBy similarity1
Binding sitei357SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processBiotin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00078

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-oxononanoate synthase (EC:2.3.1.47)
Short name:
AONS
Alternative name(s):
7-keto-8-amino-pelargonic acid synthase
Short name:
7-KAP synthase
Short name:
KAPA synthase
8-amino-7-ketopelargonate synthase
Alpha-oxoamine synthase
Gene namesi
Ordered Locus Names:Teth39_0287
OrganismiThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Taxonomic identifieri340099 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
Proteomesi
  • UP000002156 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003811231 – 3958-amino-7-oxononanoate synthaseAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei243N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiB0KC20

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi340099.Teth39_0287

Structurei

3D structure databases

ProteinModelPortaliB0KC20
SMRiB0KC20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 112Pyridoxal phosphate bindingBy similarity2
Regioni209 – 212Pyridoxal phosphate bindingBy similarity4
Regioni240 – 243Pyridoxal phosphate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107EEK Bacteria
COG0156 LUCA
HOGENOMiHOG000221022
KOiK00639
OMAiFGTIGEN

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR010962 AONS_Archaea/Firmicutes
IPR004723 AONS_Archaea/Proteobacteria
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00858 bioF, 1 hit
TIGR01825 gly_Cac_T_rel, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

B0KC20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIHDLDFI KEKLEELKKA GVYRKLTVLE SPSGPRSIID GKEVINLSSN
60 70 80 90 100
NYLGLANHPR LKKAAIEAIE KWGVGAGAVR TIIGNMTIHE ELERKLAEFK
110 120 130 140 150
REEAVLTFQS GFTANMGVIQ AVVDKGDVII SDELNHASII DGCRLSRADV
160 170 180 190 200
VIYKHSDMED LERVLKEVKD KYRVKMIITD GVFSMDGDIA KLPEIVKLAE
210 220 230 240 250
KYSAITYVDD AHASGVLGES GRGSADHFNL HGRIDIQIGT LSKAIGVVGG
260 270 280 290 300
YVAGKRELIE WLNHRGRPFL FSTALPPAAV AASIEAINIL SESDALTRKL
310 320 330 340 350
WDNAKYFKEK LKSLGFDTGK SETPITPVII GEETKALEFS RKLFEEGVFA
360 370 380 390
QGIVYPTVPK NKARVRTIVT AAHTKEDLDA ALKAFEKVGK QLNII
Length:395
Mass (Da):43,453
Last modified:March 18, 2008 - v1
Checksum:i8521E0B700489F73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000924 Genomic DNA Translation: ABY93956.1
RefSeqiWP_003867784.1, NC_010321.1

Genome annotation databases

EnsemblBacteriaiABY93956; ABY93956; Teth39_0287
KEGGitpd:Teth39_0287

Similar proteinsi

Entry informationi

Entry nameiBIOF_THEP3
AccessioniPrimary (citable) accession number: B0KC20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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