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Protein

8-amino-7-oxononanoate synthase

Gene

Teth39_0287

Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.By similarity

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].

Cofactori

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241SubstrateBy similarity
Binding sitei136 – 1361SubstrateBy similarity
Binding sitei184 – 1841Pyridoxal phosphateBy similarity
Binding sitei357 – 3571SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTPSE340099:GH4W-293-MONOMER.
UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-oxononanoate synthase (EC:2.3.1.47)
Short name:
AONS
Alternative name(s):
7-keto-8-amino-pelargonic acid synthase
Short name:
7-KAP synthase
Short name:
KAPA synthase
8-amino-7-ketopelargonate synthase
Alpha-oxoamine synthase
Gene namesi
Ordered Locus Names:Teth39_0287
OrganismiThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Taxonomic identifieri340099 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
Proteomesi
  • UP000002156 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3953958-amino-7-oxononanoate synthasePRO_0000381123Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi340099.Teth39_0287.

Structurei

3D structure databases

ProteinModelPortaliB0KC20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni111 – 1122Pyridoxal phosphate bindingBy similarity
Regioni209 – 2124Pyridoxal phosphate bindingBy similarity
Regioni240 – 2434Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107EEK. Bacteria.
COG0156. LUCA.
HOGENOMiHOG000221022.
KOiK00639.
OMAiEGSRFKL.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR010962. AONS_Archaea/Firmicutes.
IPR004723. AONS_Archaea/Proteobacteria.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00858. bioF. 1 hit.
TIGR01825. gly_Cac_T_rel. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0KC20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIHDLDFI KEKLEELKKA GVYRKLTVLE SPSGPRSIID GKEVINLSSN
60 70 80 90 100
NYLGLANHPR LKKAAIEAIE KWGVGAGAVR TIIGNMTIHE ELERKLAEFK
110 120 130 140 150
REEAVLTFQS GFTANMGVIQ AVVDKGDVII SDELNHASII DGCRLSRADV
160 170 180 190 200
VIYKHSDMED LERVLKEVKD KYRVKMIITD GVFSMDGDIA KLPEIVKLAE
210 220 230 240 250
KYSAITYVDD AHASGVLGES GRGSADHFNL HGRIDIQIGT LSKAIGVVGG
260 270 280 290 300
YVAGKRELIE WLNHRGRPFL FSTALPPAAV AASIEAINIL SESDALTRKL
310 320 330 340 350
WDNAKYFKEK LKSLGFDTGK SETPITPVII GEETKALEFS RKLFEEGVFA
360 370 380 390
QGIVYPTVPK NKARVRTIVT AAHTKEDLDA ALKAFEKVGK QLNII
Length:395
Mass (Da):43,453
Last modified:March 18, 2008 - v1
Checksum:i8521E0B700489F73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000924 Genomic DNA. Translation: ABY93956.1.
RefSeqiWP_003867784.1. NC_010321.1.

Genome annotation databases

EnsemblBacteriaiABY93956; ABY93956; Teth39_0287.
KEGGitpd:Teth39_0287.
PATRICi23885135. VBIThePse6203_0307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000924 Genomic DNA. Translation: ABY93956.1.
RefSeqiWP_003867784.1. NC_010321.1.

3D structure databases

ProteinModelPortaliB0KC20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi340099.Teth39_0287.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY93956; ABY93956; Teth39_0287.
KEGGitpd:Teth39_0287.
PATRICi23885135. VBIThePse6203_0307.

Phylogenomic databases

eggNOGiENOG4107EEK. Bacteria.
COG0156. LUCA.
HOGENOMiHOG000221022.
KOiK00639.
OMAiEGSRFKL.

Enzyme and pathway databases

UniPathwayiUPA00078.
BioCyciTPSE340099:GH4W-293-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR010962. AONS_Archaea/Firmicutes.
IPR004723. AONS_Archaea/Proteobacteria.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00858. bioF. 1 hit.
TIGR01825. gly_Cac_T_rel. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIOF_THEP3
AccessioniPrimary (citable) accession number: B0KC20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 18, 2008
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.