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B0KA34

- PYRF_THEP3

UniProt

B0KA34 - PYRF_THEP3

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, Teth39_1343
Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciTPSE340099:GH4W-1379-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:Teth39_1343
OrganismiThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Taxonomic identifieri340099 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002156: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000138961Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340099.Teth39_1343.

Structurei

3D structure databases

ProteinModelPortaliB0KA34.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiCRTSNAG.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

B0KA34-1 [UniParc]FASTAAdd to Basket

« Hide

MFIDRLIENI KSKKSPVVVG LDPRIEMTPQ FIKDIAFKKR GENIEGVCEA    50
LYLFNKGIID AVYDIVPAVK IQVAFYEAYG IEGFKAFFKT AEYAKSLGLM 100
VIADVKRGDI QEVAKMYSKA YLQNQLFDAI TVNPYMGEDT IMPYVEDAIK 150
YDKGIFALVK TSNKGSKDIQ DIKTTKGEYV YQSVARMINR ISNSAIGKYG 200
YSSIGAVVGA TYPEEAKVLR KEMPNCFFLV PGYGAQGGTV EDIMDCFDEN 250
GFGAIINSSR SVIYAYQTPY WKDVYSEYEY AQAARAEVIL MTGMINNGLV 300
KRKYIAC 307
Length:307
Mass (Da):34,406
Last modified:March 18, 2008 - v1
Checksum:i65D352F971BE8EB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000924 Genomic DNA. Translation: ABY94997.1.
RefSeqiYP_001665333.1. NC_010321.1.

Genome annotation databases

EnsemblBacteriaiABY94997; ABY94997; Teth39_1343.
GeneIDi5875060.
KEGGitpd:Teth39_1343.
PATRICi23887374. VBIThePse6203_1395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000924 Genomic DNA. Translation: ABY94997.1 .
RefSeqi YP_001665333.1. NC_010321.1.

3D structure databases

ProteinModelPortali B0KA34.
ModBasei Search...

Protein-protein interaction databases

STRINGi 340099.Teth39_1343.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY94997 ; ABY94997 ; Teth39_1343 .
GeneIDi 5875060.
KEGGi tpd:Teth39_1343.
PATRICi 23887374. VBIThePse6203_1395.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi CRTSNAG.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci TPSE340099:GH4W-1379-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33223 / 39E.

Entry informationi

Entry nameiPYRF_THEP3
AccessioniPrimary (citable) accession number: B0KA34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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