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Protein

NAD kinase

Gene

nadK

Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorUniRule annotation1
Binding sitei153NADUniRule annotation1
Binding sitei172NADUniRule annotation1
Binding sitei242NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 69NADUniRule annotation2
Nucleotide bindingi142 – 143NADUniRule annotation2
Nucleotide bindingi183 – 188NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Teth39_1105
OrganismiThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Taxonomic identifieri340099 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
Proteomesi
  • UP000002156 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208941 – 283NAD kinaseAdd BLAST283

Proteomic databases

PRIDEiB0K9E7

Interactioni

Protein-protein interaction databases

STRINGi340099.Teth39_1105

Structurei

3D structure databases

ProteinModelPortaliB0K9E7
SMRiB0K9E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B0K9E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVGVIPNI NKDKDLEVTK SVVKWLLEHD SEPYLNEIVA SKMGYDEYGK
60 70 80 90 100
KSTDIYSKSD FIIALGGDGT ILNVARLCAP FGTPIFAVNL GHLGFLTEVD
110 120 130 140 150
MNEVFVSLDK IYKGEYTVEK RMMLEANVVK NDMEIINFRA LNDIVITRGA
160 170 180 190 200
FSRMARINAY VNNNYVDTYL ADGVIIATPT GSTAYSLSAG GPIVYPTVEV
210 220 230 240 250
IIITPICPHT LYSRSIIVSP DDVIRLEISE ENQDLMITTD GQQGYKLDYR
260 270 280
DIIYIKKSNE YTNLIRVKNT NFFDLLRDKL TER
Length:283
Mass (Da):31,908
Last modified:March 18, 2008 - v1
Checksum:iDCC8D88EB7EEE705
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000924 Genomic DNA Translation: ABY94760.1
RefSeqiWP_003868020.1, NC_010321.1

Genome annotation databases

EnsemblBacteriaiABY94760; ABY94760; Teth39_1105
KEGGitpd:Teth39_1105

Similar proteinsi

Entry informationi

Entry nameiNADK_THEP3
AccessioniPrimary (citable) accession number: B0K9E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health