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B0K909

- UPPP_THEP3

UniProt

B0K909 - UPPP_THEP3

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciTPSE340099:GH4W-1000-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Teth39_0967
OrganismiThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum)
Taxonomic identifieri340099 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002156: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121HelicalUniRule annotationAdd
BLAST
Transmembranei78 – 9821HelicalUniRule annotationAdd
BLAST
Transmembranei107 – 12721HelicalUniRule annotationAdd
BLAST
Transmembranei148 – 16720HelicalUniRule annotationAdd
BLAST
Transmembranei184 – 20421HelicalUniRule annotationAdd
BLAST
Transmembranei213 – 23321HelicalUniRule annotationAdd
BLAST
Transmembranei248 – 26821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Undecaprenyl-diphosphatasePRO_1000148833Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi340099.Teth39_0967.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiVIYFRNE.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

B0K909-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLIKAFIM GIVEGLTEFL PISSTGHLII VGKFIHFTGN FATMFEIVIQ
60 70 80 90 100
LGAILAVVFH YRKKIFASLK NLKPGSWGFN LWFKIFIAFI PAAVIGLLTH
110 120 130 140 150
KYIEEHLFSP FTVAIALIAG AIMMIVIEDT FGKRYKIDNM DKVDTKKSLL
160 170 180 190 200
IGIAQVMSLF PGMSRSASTI MGGMLAGLSV KAAAEFSFFL AIPTMFAATT
210 220 230 240 250
LSLLKGFSAM SLLEWQALAV GFITSFLTAL FVVDKFLSYL TRHSLKPFAY
260
YRLAVGVLMI LLVAEKIVK
Length:269
Mass (Da):29,699
Last modified:March 18, 2008 - v1
Checksum:i6C07844F0C3D49B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000924 Genomic DNA. Translation: ABY94622.1.
RefSeqiYP_001664958.1. NC_010321.1.

Genome annotation databases

EnsemblBacteriaiABY94622; ABY94622; Teth39_0967.
GeneIDi5873447.
KEGGitpd:Teth39_0967.
PATRICi23886600. VBIThePse6203_1012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000924 Genomic DNA. Translation: ABY94622.1 .
RefSeqi YP_001664958.1. NC_010321.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 340099.Teth39_0967.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY94622 ; ABY94622 ; Teth39_0967 .
GeneIDi 5873447.
KEGGi tpd:Teth39_0967.
PATRICi 23886600. VBIThePse6203_1012.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi VIYFRNE.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci TPSE340099:GH4W-1000-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33223 / 39E.

Entry informationi

Entry nameiUPPP_THEP3
AccessioniPrimary (citable) accession number: B0K909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 18, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3