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B0K8B2 (AROC_THEP3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Teth39_0766
OrganismThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum) [Complete proteome] [HAMAP]
Taxonomic identifier340099 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Thermoanaerobacter

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Chorismate synthase HAMAP MF_00300
PRO_1000115411

Sequences

Sequence LengthMass (Da)Tools
B0K8B2 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: 9DCFA931956485FC

FASTA35038,501
        10         20         30         40         50         60 
MRYITAGESH GEALIAVIEG LPSNLLIDEE FINKELKRRQ GGYGRGGRMA IEEDKVHVLS 

        70         80         90        100        110        120 
GIRNGKTIGS PLTLEIINKD YENWKNKKTP EVTRPRPGHA DLAGAIKYNQ RDLRNILERS 

       130        140        150        160        170        180 
SARETAARVA VGSVAKLLLK ELDIYVKSKV LEIGGVKAEE KWRRTIDEAK SKGDTLGGII 

       190        200        210        220        230        240 
EIVIEGVPVG LGSHVQWDRK LDALLAYHVM SVQAIKAVEI GLGFEAARKP GSLVHDEIYY 

       250        260        270        280        290        300 
DEERGFYRKT NNAGGIEGGI SNGSPIVIKA AMKPIPTLLK PLTSIDINTK EEVKAAYERS 

       310        320        330        340        350 
DVTAVEAAAC VLEAVCAWVI ADECLKKFGG DSIEELKKNY DAYLVYVKNF

« Hide

References

[1]"Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33223 / 39E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000924 Genomic DNA. Translation: ABY94425.1.
RefSeqYP_001664761.1. NC_010321.1.

3D structure databases

ProteinModelPortalB0K8B2.
SMRB0K8B2. Positions 1-350.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0K8B2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5874350.
GenomeReviewsGene locus Teth39_0766 in contig CP000924_GR.
KEGGtpd:Teth39_0766.
PATRIC23886172. VBIThePse6203_0801.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG292336.
OMAIQTITEN.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycTPSE340099:TETH39_0766-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 2 hits.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_THEP3
AccessionPrimary (citable) accession number: B0K8B2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 18, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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