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B0K7C1 (B0K7C1_THEP3) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:Teth39_2063
OrganismThermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium thermohydrosulfuricum) [Complete proteome] [HAMAP]
Taxonomic identifier340099 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Thermoanaerobacter

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 156NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding33 – 353NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000109-3
Region129 – 1313Substrate binding By similarity PIRSR PIRSR000109-2
Region186 – 1872Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1831Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1901Proton donor By similarity PIRSR PIRSR000109-1
Binding site1031NADP By similarity PIRSR PIRSR000109-3
Binding site1031Substrate By similarity PIRSR PIRSR000109-2
Binding site1911Substrate By similarity PIRSR PIRSR000109-2
Binding site2611Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2881Substrate By similarity PIRSR PIRSR000109-2
Binding site4461Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4521Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
B0K7C1 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: 6BDCBC8237E6B128

FASTA46953,814
        10         20         30         40         50         60 
MIKADIGLIG LGVMGQNLAL NIARNGYAVS VFNKTEEKTR EFIDEKVKEE KIYPFYTLKD 

        70         80         90        100        110        120 
FVESLKKPRK IILIIKAGTP VDDVINELLS YLEKGDLIVD SGNSYFMDTS RRLKVLKEKN 

       130        140        150        160        170        180 
ILFLGMGISG GEYGALYGPS LMPGGTKEAY ELIKDVLLKV AAKTEDGPCC TYVGNDSAGH 

       190        200        210        220        230        240 
FVKMVHNGIE YAIMQLIAEV YDFMRKILNM TNEEIGDVFE RWNQEELDSY LMEISYKIMR 

       250        260        270        280        290        300 
YKDKETGGFL LDYILDKAEQ KGTGKWTAQT SLDLGVPTPT LNLAVEARVI SHYKEERKTL 

       310        320        330        340        350        360 
SKLYSKEKNT ISVNKEEMIE HLKKTLLFGV FMSFSQGLWL IYEASKQYNY GVDLSEILRI 

       370        380        390        400        410        420 
WKGGCIIRAK ILDFLRDIIR ENEEYANLLH SDKSIEFIKD KLNSVYQVLE IGRNYRIPLM 

       430        440        450        460 
IINSAVDYYF ALTEENLPAN LIQAQRDFFG AHTYERVDKE GIFHTEWEK

« Hide

References

[1]"Complete sequence of Thermoanaerobacter pseudethanolicus 39E."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000924 Genomic DNA. Translation: ABY95687.1.
RefSeqYP_001666023.1. NC_010321.1.

3D structure databases

ProteinModelPortalB0K7C1.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0K7C1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5875038.
GenomeReviewsGene locus Teth39_2063 in contig CP000924_GR.
KEGGtpd:Teth39_2063.
PATRIC23888945. VBIThePse6203_2161.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG286913.
OMAMEHNEMA.
ProtClustDBPRK09287.

Enzyme and pathway databases

BioCycTPSE340099:TETH39_2063-MONOMER.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0K7C1_THEP3
AccessionPrimary (citable) accession number: B0K7C1
Entry history
Integrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info