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B0K6M6 (G6PI_THEPX) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:Teth514_1208
OrganismThermoanaerobacter sp. (strain X514) [Complete proteome] [HAMAP]
Taxonomic identifier399726 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Thermoanaerobacter

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_1000125770

Sites

Active site3121 By similarity
Active site4261 By similarity

Sequences

Sequence LengthMass (Da)Tools
B0K6M6 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: 8C9629A12752CCB0

FASTA45150,670
        10         20         30         40         50         60 
MRKLISFDYS KALQFVSEKE IEYMERHAKL SLDMVLSKNA QGNDFLGWVS LPKDYDKAEF 

        70         80         90        100        110        120 
ERIKKAAEKI KSDSDVLVVI GIGGSYLGAR AAIEMLSHSF YNLLPKGKRN MPEIYFAGNS 

       130        140        150        160        170        180 
ISSTYLSDLF ELIEDKDVSI NVISKSGTTT EPAIAFRVFR DFLEKKYGKE GAKSRIYVTT 

       190        200        210        220        230        240 
DRAKGALKKL ADEEGYETFV IPDNVGGRYS VLTAVGLLPI AVAGISIDDM MQGAYDASTV 

       250        260        270        280        290        300 
YTKDNLNENI SMQYAILRNI LYRKGKAIEI LVNYEPKLHY FSEWWKQLFG ESEGKDNKGI 

       310        320        330        340        350        360 
YPASVDFTTD LHSMGQFIQE GSRNIFETVL NVEKPVKDIV INEDKDNIDG LNFLAGKTID 

       370        380        390        400        410        420 
FVNKKAFEGT LLAHTDGNVP NLVVNIPEIS AYYFGNLVYF FEMACAISGY INGVNPFDQP 

       430        440        450 
GVEAYKKNMF ALLGKPGYEK EKELLEKRLG K

« Hide

References

[1]"Complete sequence of Thermoanaerobacter sp. X514."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: X514.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000923 Genomic DNA. Translation: ABY92502.1.
RefSeqYP_001662838.1. NC_010320.1.

3D structure databases

ProteinModelPortalB0K6M6.
SMRB0K6M6. Positions 5-449.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0K6M6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5877011.
GenomeReviewsGene locus Teth514_1208 in contig CP000923_GR.
KEGGtex:Teth514_1208.
PATRIC23892048. VBITheSp86957_1261.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG615843.
OMAGQGNDFL.
ProtClustDBPRK14097.

Enzyme and pathway databases

BioCycTSP1755:TETH514_1208-MONOMER.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_THEPX
AccessionPrimary (citable) accession number: B0K6M6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 18, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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