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B0K6A9 (B0K6A9_THEPX) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Galactokinase HAMAP-Rule MF_00246
EC=2.7.1.6 HAMAP-Rule MF_00246
Alternative name(s):
Galactose kinase HAMAP-Rule MF_00246
Gene names
Name:galK HAMAP-Rule MF_00246
Ordered Locus Names:Teth514_1087
OrganismThermoanaerobacter sp. (strain X514) [Complete proteome] [HAMAP] EMBL ABY92385.1
Taxonomic identifier399726 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteraceae › Thermoanaerobacter

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) By similarity. HAMAP-Rule MF_00246 SAAS SAAS006206

Catalytic activity

ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP-Rule MF_00246 SAAS SAAS006206

Pathway

Carbohydrate metabolism; galactose metabolism. HAMAP-Rule MF_00246 SAAS SAAS006206

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00246 SAAS SAAS006206.

Sequence similarities

Belongs to the GHMP kinase family. GalK subfamily. HAMAP-Rule MF_00246

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding122 – 1287ATP By similarity HAMAP-Rule MF_00246
Region34 – 374Substrate binding By similarity HAMAP-Rule MF_00246

Sites

Active site1721Proton acceptor By similarity HAMAP-Rule MF_00246
Metal binding1281Magnesium By similarity HAMAP-Rule MF_00246
Metal binding1601Magnesium By similarity HAMAP-Rule MF_00246
Binding site681ATP By similarity HAMAP-Rule MF_00246
Binding site2221Substrate By similarity HAMAP-Rule MF_00246
Site281Transition state stabilizer By similarity HAMAP-Rule MF_00246

Sequences

Sequence LengthMass (Da)Tools
B0K6A9 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: 1A682E268355A92B

FASTA38743,382
        10         20         30         40         50         60 
MKTAVIEALE KFYGKNDAEI RLFYSPGRVN LIGEHTDYNG GYVFPCALDF GTYAAIRKRN 

        70         80         90        100        110        120 
DKKVFMASLN FDLKVEVDLD ALNFDKSHDW ANYPKGVLKV LQDEGYDFSG FEIVFEGNIP 

       130        140        150        160        170        180 
NGAGLSSSAS IELVTAVAVN EVFNLNIDRI KLVKLCQKAE NTFVGVNCGI MDQFAVGMGK 

       190        200        210        220        230        240 
KDHAILLKSD TLEYSYVPLK LEGYKILITN TNKRRGLLDS KYNERRSECE KALSYLQKAL 

       250        260        270        280        290        300 
PVKNLSEITI EQFEEYKDLI PDEVLRKRAK HVITENKRVL DAVKALNDKD LIKFGELMVE 

       310        320        330        340        350        360 
SHNSLRDDYE VTGKELDTLV EEALKLKGVI GSRMTGAGFG GCTVSIVKED AVEEFIKVVT 

       370        380 
HNYTQKIGYR PTVYITGIGE GAGEIKY

« Hide

References

[1]"Complete sequence of Thermoanaerobacter sp. X514."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: X514.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000923 Genomic DNA. Translation: ABY92385.1.
RefSeqYP_001662721.1. NC_010320.1.

3D structure databases

ProteinModelPortalB0K6A9.
ModBaseSearch...

Protein-protein interaction databases

STRING399726.Teth514_1087.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY92385; ABY92385; Teth514_1087.
GeneID5876545.
KEGGtex:Teth514_1087.
PATRIC23891794. VBITheSp86957_1134.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0153.
HOGENOMHOG000241101.
KOK00849.
OMAMPCAINY.
ProtClustDBPRK05322.

Enzyme and pathway databases

UniPathwayUPA00214.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00246. Galactokinase.
InterProIPR000705. Galactokinase.
IPR022963. Galactokinase_bac.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000530. Galactokinase. 1 hit.
PRINTSPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00131. gal_kin. 1 hit.
PROSITEPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0K6A9_THEPX
AccessionPrimary (citable) accession number: B0K6A9
Entry history
Integrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info