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B0K5Y9

- B0K5Y9_THEPX

UniProt

B0K5Y9 - B0K5Y9_THEPX

Protein

Alanine racemase

Gene

Teth514_0964

Organism
Thermoanaerobacter sp. (strain X514)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei39 – 391Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei137 – 1371SubstrateUniRule annotation
    Active sitei267 – 2671Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTSP399726:GHCK-998-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Teth514_0964Imported
    OrganismiThermoanaerobacter sp. (strain X514)Imported
    Taxonomic identifieri399726 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000002155: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi399726.Teth514_0964.

    Structurei

    3D structure databases

    ProteinModelPortaliB0K5Y9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiWRDMARR.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0K5Y9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFDNIRPTRA EIYLDNIVHN LSEVKRWVGK KVKIMGVVKA NAYGHGACQV    50
    AKVLIENGVS YLGVATIEEA LELRECGINI PILVFGYTPL PQAKELIVHN 100
    ITQTVFDINY VKDLERIALN VGKKAKVHVK VDTGMGRIGY TDLNVAEKEI 150
    EKMMEMEGVE VEGIFSHFAT SDEKDKTYAE QQFDMFKKLL ESLKQKEINI 200
    PLKHIANSGA IIDLKYTYLD MVRPGIVLYG SYPSENVERP LDLRQTMGFK 250
    TKIVYIKEVP EGTSISYGRT FITKRKSKIA TLPVGYADGF NRLLSNNHHV 300
    LVKGKYAPVI GRICMDQTML DVTDIEGVEV GDDVTIFGNQ DGEKITAEEI 350
    AKKLNTIPYE VYCGISRRVP RIYIYKGEVI EVKNYLKI 388
    Length:388
    Mass (Da):43,792
    Last modified:March 18, 2008 - v1
    Checksum:i35EE01B5FB0C3AEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY92265.1.
    RefSeqiYP_001662601.1. NC_010320.1.

    Genome annotation databases

    EnsemblBacteriaiABY92265; ABY92265; Teth514_0964.
    GeneIDi5875853.
    KEGGitex:Teth514_0964.
    PATRICi23891544. VBITheSp86957_1010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY92265.1 .
    RefSeqi YP_001662601.1. NC_010320.1.

    3D structure databases

    ProteinModelPortali B0K5Y9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399726.Teth514_0964.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY92265 ; ABY92265 ; Teth514_0964 .
    GeneIDi 5875853.
    KEGGi tex:Teth514_0964.
    PATRICi 23891544. VBITheSp86957_1010.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi WRDMARR.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci TSP399726:GHCK-998-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X514Imported.

    Entry informationi

    Entry nameiB0K5Y9_THEPX
    AccessioniPrimary (citable) accession number: B0K5Y9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3