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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Thermoanaerobacter sp. (strain X514)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:Teth514_0859
OrganismiThermoanaerobacter sp. (strain X514)
Taxonomic identifieri399726 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
Proteomesi
  • UP000002155 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001658311 – 1238DNA-directed RNA polymerase subunit betaAdd BLAST1238

Proteomic databases

PRIDEiB0K5G8.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0K5G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiPOG091H01MI.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0K5G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRPVQVGNK TRMSFAKIDE VLQMPDLIEV QKKSYKWFLE EGLREVFREI
60 70 80 90 100
SPIESFTGNL ALEFVDYRLE NNPKYSVEEC KDRDTTYAVP MKVKVRLTNR
110 120 130 140 150
ETGEIKESEV FMGDFPLMTE KGTFIINGAE RVIVSQLVRS PGVYYEQQFD
160 170 180 190 200
KFGKKLISAT VIPNRGAWLE YEEDSNDIVY VRIDRTRKVP ITVLLRALGY
210 220 230 240 250
STDIQILDLL GEEEKLKATL DKDTTKSEEE ALIEIYKRLR PGEPPTVESA
260 270 280 290 300
KSLLYALFFD AKRYDLAKVG RYKFNKKLAL KARIANLKSA KKIVNPVTGE
310 320 330 340 350
ILVEEGEKIS KEKAEEIQNC GINVVEVLVE GKVVKVIGNN TVDINKYPMP
360 370 380 390 400
YDVSSLNIKE AVNLSILKEI LDNFSDEEAV INEIKNRMDE LVPKHITKDD
410 420 430 440 450
IIATISYQLN LTHGIGSIDD IDHLGNRRLR SVGELLQNQF RIGLARLERV
460 470 480 490 500
VKERMTIQDV NEITPQNLIN IRPVVAAIRE FFGSSQLSQF MDQTNPLAEL
510 520 530 540 550
THKRRVSALG PGGLSRERAG FEVRDVHYSH YGRICPIETP EGPNIGLIGS
560 570 580 590 600
LTTYARVNEY GFIEAPYRRV DKTTGTVTDE IVYMTADEED EYIIAQANEP
610 620 630 640 650
LDENNRFINE KVVCRLKEEI IAVPPTEVDF MDVSPKQIVS VATSMIPFLE
660 670 680 690 700
NDDANRALMG SNMQRQAVPL IKPEAPIIGT GIEYKAAVDS GVVVLAKNDG
710 720 730 740 750
VVEKVAADKV VIRTKDGRRD EYNLLKFKRS NQGTCINQRP IVNEGDEVKK
760 770 780 790 800
GQVICDGPST DHGELALGKN VLVGFMLWEG YNYEDAILIS EELVRDDSLT
810 820 830 840 850
SIHIEEYDAE ARDTKLGPEE ITREIPNVGE DALKDLDERG IIRIGAEVTA
860 870 880 890 900
GDILVGKVTP KGETELTAEE RLLRAIFGEK AREVRDTSLR VPHGESGIVV
910 920 930 940 950
DVKVYSRENG DELPPGVNQM VRVFVAQKRK ISVGDKMAGR HGNKGVISRI
960 970 980 990 1000
LPVEDMPFLP DGTPLQICLN PLGVPSRMNI GQVLEVHLGL VAKALGWQIA
1010 1020 1030 1040 1050
TPVFDGATEE DIQELLAKSG FSPDGKVQLY DGRTGEPFDN KVTVGYMYML
1060 1070 1080 1090 1100
KLHHLVDDKM HARSTGPYSL VTQQPLGGKA QFGGQRFGEM EVWALEAYGA
1110 1120 1130 1140 1150
AHTLQEILTV KSDDVSGRVK TYEAIVKGEN IPEPGIPESF KVLVKELQSL
1160 1170 1180 1190 1200
ALDVKVITED NQEIPLKEFE DDDDSDVPDA TLNINIEGRE DTPPEEVYEE
1210 1220 1230
GYEEGFEEES EELPEDIDFE PDSFDIENDD LDLEDFDI
Length:1,238
Mass (Da):138,833
Last modified:March 18, 2008 - v1
Checksum:iC00538F2F6DC6076
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000923 Genomic DNA. Translation: ABY92161.1.
RefSeqiWP_003868699.1. NC_010320.1.

Genome annotation databases

EnsemblBacteriaiABY92161; ABY92161; Teth514_0859.
KEGGitex:Teth514_0859.
PATRICi23891312. VBITheSp86957_0904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000923 Genomic DNA. Translation: ABY92161.1.
RefSeqiWP_003868699.1. NC_010320.1.

3D structure databases

ProteinModelPortaliB0K5G8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB0K5G8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY92161; ABY92161; Teth514_0859.
KEGGitex:Teth514_0859.
PATRICi23891312. VBITheSp86957_0904.

Phylogenomic databases

HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiPOG091H01MI.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOB_THEPX
AccessioniPrimary (citable) accession number: B0K5G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.