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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Thermoanaerobacter sp. (strain X514)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei255ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSP399726:G1GAX-876-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:Teth514_0844
OrganismiThermoanaerobacter sp. (strain X514)
Taxonomic identifieri399726 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
Proteomesi
  • UP000002155 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677831 – 485Glutamate--tRNA ligase 1Add BLAST485

Proteomic databases

PRIDEiB0K5F4

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0K5F4
SMRiB0K5F4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi252 – 256"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252720
KOiK09698
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B0K5F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLRVRFAP SPTGAIHIGN IRTALFNYLF SRSEGATFVL RIEDTDLERS
60 70 80 90 100
SKEFEELIFK ELEWLGIEWD EGPDKPGPYG PYRQSERLEI YHKFAQKLIE
110 120 130 140 150
EKKAYRCYCT PEELEEDRRK AVERGDIPRY SGRCRYLTKE QEEAFIREGR
160 170 180 190 200
KPVIRFIIPD DEVIEFEDMI KGKITIKSDT LGGDMVIVKS DGMPTYNFAV
210 220 230 240 250
VIDDALMKIT HVIRGEDHIY NTPKQILIYK ALGFEIPKFA HAPLILGPDR
260 270 280 290 300
TKLSKRHGNT YIGQYRELGY LPEAMFNFLS LLSWSPEDNV EIMSKEEIIK
310 320 330 340 350
KFNFRRIHSA NPVFDIEKLN WMNQQYIQKS SIERIVDLAI PHLRRAGYID
360 370 380 390 400
GIDDMVYNWL KDVISLYKDG LQYVAQITEK AKMFFVEEVE YSDETVKILN
410 420 430 440 450
SPNSKIVLEV VKKVIEEADE ITEEYVKDLL KKLQKETKVK GKEFFMPIRV
460 470 480
AITGEDHGPE LVKIIPLLGK DKVINRLKKA INLIK
Length:485
Mass (Da):56,471
Last modified:March 18, 2008 - v1
Checksum:i9F1B4B1D2ABC4617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000923 Genomic DNA Translation: ABY92147.1
RefSeqiWP_009052841.1, NC_010320.1

Genome annotation databases

EnsemblBacteriaiABY92147; ABY92147; Teth514_0844
KEGGitex:Teth514_0844

Similar proteinsi

Entry informationi

Entry nameiSYE1_THEPX
AccessioniPrimary (citable) accession number: B0K5F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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