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B0K5A5

- FTHS_THEPX

UniProt

B0K5A5 - FTHS_THEPX

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Teth514_0795
Organism
Thermoanaerobacter sp. (strain X514)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSP399726:GHCK-818-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Teth514_0795
OrganismiThermoanaerobacter sp. (strain X514)
Taxonomic identifieri399726 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002155: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000146707Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399726.Teth514_0795.

Structurei

3D structure databases

ProteinModelPortaliB0K5A5.
SMRiB0K5A5. Positions 4-553.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0K5A5-1 [UniParc]FASTAAdd to Basket

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MKSDIEIAQE AKMLHIREVA KKLDIEEDYL EYYGKYKAKI SPALSEKIKD    50
RKDGKLILVT AITPTPAGEG KTTLTVGLGQ ALAKIGKKAM IALREPSLGP 100
CMGIKGGAAG GGYSQVVPME DINLHFTGDL HAITAAHNLL AAMIDNHIHH 150
GNELNIDIRA ITWKRAMDMN DRALREIIVG LGGKANGFPR QDGFIITVAS 200
EVMAILCLAQ DLMDLKRRIG DIIVAYDKDG NPVTARDLKA DGAMTVLLKD 250
AIKPNLVQTI ENVPAFVHGG PFANIAHGCN SLIATKYGLK LADYLVTEAG 300
FGADLGAEKF FDIKSRFGGL TPNAAVIVAT VRALKMHGGV KKEDLQKEDV 350
EAVRRGIENL EKQVENVRKF GVPVVVALNR FVFDTEREIE EVRKACEEMG 400
VDMAVAEVWE KGGEGGIELA EKVVKACETP SNFHVLYDET LPIKDKLHII 450
ATEIYGADGV EYTASALKDI ANLERLGFDK MPIVVAKTQY SLSDDPKLLG 500
RPRGFKITVR ELRVSMGAGF VVVFTGDIMT MPGLPKHPAA ENIDIDENGR 550
ITGLF 555
Length:555
Mass (Da):60,378
Last modified:March 18, 2008 - v1
Checksum:iE6AB1DF55C49FC23
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000923 Genomic DNA. Translation: ABY92098.1.
RefSeqiYP_001662434.1. NC_010320.1.

Genome annotation databases

EnsemblBacteriaiABY92098; ABY92098; Teth514_0795.
GeneIDi5877354.
KEGGitex:Teth514_0795.
PATRICi23891179. VBITheSp86957_0839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000923 Genomic DNA. Translation: ABY92098.1 .
RefSeqi YP_001662434.1. NC_010320.1.

3D structure databases

ProteinModelPortali B0K5A5.
SMRi B0K5A5. Positions 4-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399726.Teth514_0795.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY92098 ; ABY92098 ; Teth514_0795 .
GeneIDi 5877354.
KEGGi tex:Teth514_0795.
PATRICi 23891179. VBITheSp86957_0839.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci TSP399726:GHCK-818-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X514.

Entry informationi

Entry nameiFTHS_THEPX
AccessioniPrimary (citable) accession number: B0K5A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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