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B0K5A5

- FTHS_THEPX

UniProt

B0K5A5 - FTHS_THEPX

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermoanaerobacter sp. (strain X514)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTSP399726:GHCK-818-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Teth514_0795
    OrganismiThermoanaerobacter sp. (strain X514)
    Taxonomic identifieri399726 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000002155: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_1000146707Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399726.Teth514_0795.

    Structurei

    3D structure databases

    ProteinModelPortaliB0K5A5.
    SMRiB0K5A5. Positions 4-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0K5A5-1 [UniParc]FASTAAdd to Basket

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    MKSDIEIAQE AKMLHIREVA KKLDIEEDYL EYYGKYKAKI SPALSEKIKD    50
    RKDGKLILVT AITPTPAGEG KTTLTVGLGQ ALAKIGKKAM IALREPSLGP 100
    CMGIKGGAAG GGYSQVVPME DINLHFTGDL HAITAAHNLL AAMIDNHIHH 150
    GNELNIDIRA ITWKRAMDMN DRALREIIVG LGGKANGFPR QDGFIITVAS 200
    EVMAILCLAQ DLMDLKRRIG DIIVAYDKDG NPVTARDLKA DGAMTVLLKD 250
    AIKPNLVQTI ENVPAFVHGG PFANIAHGCN SLIATKYGLK LADYLVTEAG 300
    FGADLGAEKF FDIKSRFGGL TPNAAVIVAT VRALKMHGGV KKEDLQKEDV 350
    EAVRRGIENL EKQVENVRKF GVPVVVALNR FVFDTEREIE EVRKACEEMG 400
    VDMAVAEVWE KGGEGGIELA EKVVKACETP SNFHVLYDET LPIKDKLHII 450
    ATEIYGADGV EYTASALKDI ANLERLGFDK MPIVVAKTQY SLSDDPKLLG 500
    RPRGFKITVR ELRVSMGAGF VVVFTGDIMT MPGLPKHPAA ENIDIDENGR 550
    ITGLF 555
    Length:555
    Mass (Da):60,378
    Last modified:March 18, 2008 - v1
    Checksum:iE6AB1DF55C49FC23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY92098.1.
    RefSeqiYP_001662434.1. NC_010320.1.

    Genome annotation databases

    EnsemblBacteriaiABY92098; ABY92098; Teth514_0795.
    GeneIDi5877354.
    KEGGitex:Teth514_0795.
    PATRICi23891179. VBITheSp86957_0839.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY92098.1 .
    RefSeqi YP_001662434.1. NC_010320.1.

    3D structure databases

    ProteinModelPortali B0K5A5.
    SMRi B0K5A5. Positions 4-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399726.Teth514_0795.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY92098 ; ABY92098 ; Teth514_0795 .
    GeneIDi 5877354.
    KEGGi tex:Teth514_0795.
    PATRICi 23891179. VBITheSp86957_0839.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci TSP399726:GHCK-818-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X514.

    Entry informationi

    Entry nameiFTHS_THEPX
    AccessioniPrimary (citable) accession number: B0K5A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3