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B0K4D8

- ASSY_THEPX

UniProt

B0K4D8 - ASSY_THEPX

Protein

Argininosuccinate synthase

Gene

argG

Organism
Thermoanaerobacter sp. (strain X514)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881CitrullineUniRule annotation
    Binding sitei93 – 931CitrullineUniRule annotation
    Binding sitei118 – 1181ATP; via amide nitrogenUniRule annotation
    Binding sitei120 – 1201AspartateUniRule annotation
    Binding sitei124 – 1241AspartateUniRule annotation
    Binding sitei124 – 1241CitrullineUniRule annotation
    Binding sitei125 – 1251AspartateUniRule annotation
    Binding sitei128 – 1281CitrullineUniRule annotation
    Binding sitei177 – 1771CitrullineUniRule annotation
    Binding sitei186 – 1861CitrullineUniRule annotation
    Binding sitei262 – 2621CitrullineUniRule annotation
    Binding sitei274 – 2741CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTSP399726:GHCK-682-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Teth514_0663
    OrganismiThermoanaerobacter sp. (strain X514)
    Taxonomic identifieri399726 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000002155: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Argininosuccinate synthasePRO_1000089058Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi399726.Teth514_0663.

    Structurei

    3D structure databases

    ProteinModelPortaliB0K4D8.
    SMRiB0K4D8. Positions 6-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0K4D8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKGEKVVLA YSGGLDTSVI IPWLKENYEC EIIAACINVG QGEELKYIKD    50
    KALASGASKV YIEDVKEEFV KDYIFPTLKA GAVYEGKYLL GTSMARPLIA 100
    KKLVEIAHKE GAKAIAHGAT GKGNDQVRFE VSIHALDPSI KIIAPWRIWD 150
    LKSREDEIDY AKKKGIPIPV TKEKIYSVDN NLWHVSHEGG DLEDPWNEPK 200
    SDLYDIITPP DKAPDKPEYV LIEFEKGIPV KVNGKALEPV KLIEELNAIA 250
    GRNGVGIADL VENRLVGMKS RGVYETPAGT LLYAAHKELE YLVLDKETMR 300
    FKDLVSQKYA DLVYNGLWFS PLKAALDAFV EETQKNVTGV VRLKLYKGNV 350
    INAGVKSPYS LYNQEFVTFG KDEVYNQKDA EGFINLFGLS LKIKALMEME 400
    RKDMDEAVGR 410
    Length:410
    Mass (Da):45,806
    Last modified:March 18, 2008 - v1
    Checksum:iBCDBEC1658CB4CC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY91971.1.
    RefSeqiYP_001662307.1. NC_010320.1.

    Genome annotation databases

    EnsemblBacteriaiABY91971; ABY91971; Teth514_0663.
    GeneIDi5875824.
    KEGGitex:Teth514_0663.
    PATRICi23890879. VBITheSp86957_0693.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY91971.1 .
    RefSeqi YP_001662307.1. NC_010320.1.

    3D structure databases

    ProteinModelPortali B0K4D8.
    SMRi B0K4D8. Positions 6-398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399726.Teth514_0663.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY91971 ; ABY91971 ; Teth514_0663 .
    GeneIDi 5875824.
    KEGGi tex:Teth514_0663.
    PATRICi 23890879. VBITheSp86957_0693.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci TSP399726:GHCK-682-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X514.

    Entry informationi

    Entry nameiASSY_THEPX
    AccessioniPrimary (citable) accession number: B0K4D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3