B0K371 (B0K371_THEPX) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutase PIRNR PIRNR001338
Short name=N5-CAIR mutase PIRNR PIRNR001338
EC=5.4.99.18 PIRNR PIRNR001338

Gene names

Ordered Locus Names:

Teth514_0433

Organism

Thermoanaerobacter sp. (strain X514) [Complete proteome] [HAMAP] EMBL ABY91743.1

Taxonomic identifier

399726 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteraceae › Thermoanaerobacter

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity. PIRNR PIRNR001338
Catalytic activity	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. PIRNR PIRNR001338
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. PIRNR PIRNR001338
Sequence similarities	Belongs to the AIR carboxylase family. PIRNR PIRNR001338

Ontologies

Keywords
Biological process	Purine biosynthesis PIRNR PIRNR001338
Molecular function	Isomerase PIRNR PIRNR001338 Lyase EMBL ABY91743.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	5-(carboxyamino)imidazole ribonucleotide mutase activity Inferred from electronic annotation. Source: EC lyase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Binding site	12	1	Substrate By similarity PIRSR PIRSR001338-1
	Binding site	15	1	Substrate By similarity PIRSR PIRSR001338-1
	Binding site	42	1	Substrate By similarity PIRSR PIRSR001338-1

Sequences

	Sequence		Length	Mass (Da)
	B0K371 [UniParc]. Last modified March 18, 2008. Version 1. Checksum: 7B5D8F977F522684	FASTA	175	18,890
	10 20 30 40 50 60 MKKPLAGIIM GSDSDLPVMK EAAKVLEDFG VEYEITIVSA HRTLERMFKY AKEAEQRGID 70 80 90 100 110 120 VIIAGAGGAA HLPGMVAAIS SLPVIGVPVK TSSLNGLDSL LSIVQMPAGV PVATVAINNA 130 140 150 160 170 KNAGILAAEI LGIKYPEIRE KIIEFKEKMR KEVEEKAKDL ENIGYEEYLG RRQNA

References

[1]

"Complete sequence of Thermoanaerobacter sp. X514." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Hemme C., Fields M.W., He Z., Zhou J., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: X514.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000923 Genomic DNA. Translation: ABY91743.1.
RefSeq	YP_001662079.1. NC_010320.1.
3D structure databases
ProteinModelPortal	B0K371.
SMR	B0K371. Positions 4-172.
ModBase	Search...
Protein-protein interaction databases
STRING	399726.Teth514_0433.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABY91743; ABY91743; Teth514_0433.
GeneID	5877538.
KEGG	tex:Teth514_0433.
PATRIC	23890362. VBITheSp86957_0449.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0041.
HOGENOM	HOG000034141.
KO	K01588.
OMA	KHACDIL.
ProtClustDB	CLSK2399979.
Enzyme and pathway databases
UniPathway	UPA00074; UER00943.
Family and domain databases
Gene3D	3.40.50.7700. 1 hit.
InterPro	IPR024694. N5-CAIR_mutase_PurE. IPR000031. N5-CAIR_Mutase_PurE_dom. [Graphical view]
Pfam	PF00731. AIRC. 1 hit. [Graphical view]
PIRSF	PIRSF001338. AIR_carboxylase. 1 hit.
SMART	SM01001. AIRC. 1 hit. [Graphical view]
SUPFAM	SSF52255. AIR_carboxyl. 1 hit.
TIGRFAMs	TIGR01162. purE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B0K371_THEPX

Accession

Primary (citable) accession number: B0K371

Entry history

Integrated into UniProtKB/TrEMBL:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)