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B0K2V6 (MTNA_THEPX) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylthioribose-1-phosphate isomerase
Short name=M1Pi
Short name=MTR-1-P isomerase
EC=5.3.1.23
Alternative name(s):
S-methyl-5-thioribose-1-phosphate isomerase
Gene names
Name:mtnA
Ordered Locus Names:Teth514_1881
OrganismThermoanaerobacter sp. (strain X514) [Complete proteome] [HAMAP]
Taxonomic identifier399726 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Thermoanaerobacter

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) By similarity. HAMAP MF_01678

Catalytic activity

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate. HAMAP MF_01678

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. HAMAP MF_01678

Sequence similarities

Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Methionine biosynthesis
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmethionine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionS-methyl-5-thioribose-1-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Methylthioribose-1-phosphate isomerase HAMAP MF_01678
PRO_0000357257

Regions

Region47 – 493Substrate binding By similarity
Region248 – 2492Substrate binding By similarity

Sites

Active site2381Proton donor By similarity
Binding site901Substrate By similarity
Binding site1971Substrate By similarity
Site1581Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
B0K2V6 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: F29C9FC14060CEF4

FASTA34538,523
        10         20         30         40         50         60 
MKEIKSIEFK NEVLYLIDQR KLPNSYEIFE CKTYRDVNFA IKEMVVRGAP AIGAAAAYGV 

        70         80         90        100        110        120 
VLAAKEFLKE DREIFFEKIE EALEVIANSR PTAVNLMWAV KRMKKVIEKN KELELIDIYQ 

       130        140        150        160        170        180 
ALKKEADSIY LEDIETNKKM AKFGNEVIKE NAVILTHCNT GALATVGYGT ALGVIREAHY 

       190        200        210        220        230        240 
SGKNIFVYAD ETRPRLQGSK LTAWELVQEG IPAKLIADSV AATLIRDGKI DVILVGADRI 

       250        260        270        280        290        300 
ALNGDTANKI GTFMLSVIAK VYNVPFYVVA PTSTIDFEIE SGKEIIIEER SPEEVTHING 

       310        320        330        340 
VRIAPEGIEV YNPAFDVTPH ENITGIITEK GIIKPPYKEN ILKLK

« Hide

References

[1]"Complete sequence of Thermoanaerobacter sp. X514."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: X514.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000923 Genomic DNA. Translation: ABY93161.1.
RefSeqYP_001663497.1. NC_010320.1.

3D structure databases

ProteinModelPortalB0K2V6.
SMRB0K2V6. Positions 3-344.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0K2V6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5877423.
GenomeReviewsGene locus Teth514_1881 in contig CP000923_GR.
KEGGtex:Teth514_1881.
PATRIC23893446. VBITheSp86957_1947.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG682649.
OMARPRNQGA.
ProtClustDBCLSK901319.

Enzyme and pathway databases

BioCycTSP1755:TETH514_1881-MONOMER.

Family and domain databases

HAMAPMF_01678. Salvage_MtnA.
[Tree]
InterProIPR000649. IF-2B-related.
IPR005251. IF-2BI_MTNA.
IPR011559. Initiation_fac_2B_a/b/d.
[Graphical view]
KOK08963.
PANTHERPTHR10233. IF-2B_related. 1 hit.
PTHR10233:SF6. PTHR10233:SF6. 1 hit.
PfamPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsTIGR00524. EIF-2B_rel. 1 hit.
TIGR00512. Salvage_mtnA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTNA_THEPX
AccessionPrimary (citable) accession number: B0K2V6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: March 18, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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