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B0K2E7 (PYRF_THEPX) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:Teth514_1816
OrganismThermoanaerobacter sp. (strain X514) [Complete proteome] [HAMAP]
Taxonomic identifier399726 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_1000138962

Sites

Active site1061Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
B0K2E7 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: 7D7E78CBE48E0881

FASTA30734,315
        10         20         30         40         50         60 
MFIDKLIESI KAKKSPVVVG LDPRIEKTPQ FIKDVAFKRK GENIEGISEA LYLFNKGIID 

        70         80         90        100        110        120 
AVYDIVPAVK IQVAFYEAYG IEGFKAFFKT AEYAKSLGLM VIADVKRGDI QEVAKMYSKA 

       130        140        150        160        170        180 
YLQNQLFDAI TVNPYMGEDT IMPYVEDAIK YNKGIFALVK TSNKGSKDIQ DIKTTKGEYV 

       190        200        210        220        230        240 
YQSVARMINR ISNSAIGKYG YSSIGAVVGA TYPEEAKVLR KEMPNCFFLV PGYGAQGGTV 

       250        260        270        280        290        300 
EDIMDCFDEN GFGAIINSSR SVIYAYQTPY WKDVYSEYEY AQAARAEVIL MTGMINNGLV 


KRKYIAC 

« Hide

References

[1]"Complete sequence of Thermoanaerobacter sp. X514."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Hemme C., Fields M.W., He Z., Zhou J., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: X514.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000923 Genomic DNA. Translation: ABY93098.1.
RefSeqYP_001663434.1. NC_010320.1.

3D structure databases

ProteinModelPortalB0K2E7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING399726.Teth514_1816.

Proteomic databases

PRIDEB0K2E7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY93098; ABY93098; Teth514_1816.
GeneID5877931.
KEGGtex:Teth514_1816.
PATRIC23893308. VBITheSp86957_1879.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000245747.
KOK01591.
OMACRTSNAG.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycTSP399726:GHCK-1861-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRF_THEPX
AccessionPrimary (citable) accession number: B0K2E7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways