B0K1W5 (PLSX_THEPX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphate acyltransferase
EC=2.3.1.n2

Alternative name(s):
Acyl-ACP phosphotransacylase
Acyl-[acyl-carrier-protein]--phosphate acyltransferase
Phosphate-acyl-ACP acyltransferase

Gene names

Name:	plsX
Ordered Locus Names:	Teth514_1727

Organism

Thermoanaerobacter sp. (strain X514) [Complete proteome] [HAMAP]

Taxonomic identifier

399726 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteraceae › Thermoanaerobacter

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible formation of acyl-phosphate (acyl-PO4) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA By similarity. HAMAP-Rule MF_00019
Catalytic activity	Acyl-[acyl-carrier-protein] + phosphate = acyl-phosphate + [acyl-carrier-protein]. HAMAP-Rule MF_00019
Pathway	Lipid metabolism; phospholipid metabolism. HAMAP-Rule MF_00019
Subunit structure	Homodimer. Probably interacts with PlsY By similarity. HAMAP-Rule MF_00019
Subcellular location	Cytoplasm By similarity. Note: Associated with the membrane possibly through PlsY By similarity. HAMAP-Rule MF_00019
Sequence similarities	Belongs to the PlsX family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: InterPro phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Phosphate acyltransferase HAMAP-Rule MF_00019		PRO_1000089946

Sequences

	Sequence		Length	Mass (Da)
	B0K1W5 [UniParc]. Last modified March 18, 2008. Version 1. Checksum: 409A1BA533C46481	FASTA	332	36,033
	10 20 30 40 50 60 MRLAIDAMGG DHAPEEIIKG SLEALKHFHD IEIVLIGKEE VLRGLQGKEK RLKLVYASEV 70 80 90 100 110 120 IENDEVPVTA VRKKKDSSMI VGLELLKKEE VDAFLSAGNT GALMAGALLT LGRIKGIDRP 130 140 150 160 170 180 ALAPILPTLN GATVLLDAGS NTNCDAQNLV QFAAMGHVYA QKMFGIERPR VGLFNIGVEE 190 200 210 220 230 240 EKGNEVVKKA FEELKKSKLN FIGNVEGRDI PYGVCEVVVC DGFVGNAILK SMEGIASVIS 250 260 270 280 290 300 QLLKEELTRN IFTKLGALLI MGGLKRITKK MDYTEYGGAP LLGIKKPVIK AHGNSKAKAI 310 320 330 FNAIKQAKNF VDNDVLNHIK EEIESMGDEL SV

References

[1]

"Complete sequence of Thermoanaerobacter sp. X514." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Hemme C., Fields M.W., He Z., Zhou J., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: X514.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000923 Genomic DNA. Translation: ABY93013.1.
RefSeq	YP_001663349.1. NC_010320.1.
3D structure databases
ProteinModelPortal	B0K1W5.
ModBase	Search...
Protein-protein interaction databases
STRING	399726.Teth514_1727.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABY93013; ABY93013; Teth514_1727.
GeneID	5876567.
KEGG	tex:Teth514_1727.
PATRIC	23893116. VBITheSp86957_1789.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0416.
HOGENOM	HOG000154731.
KO	K03621.
OMA	DEKPSQA.
ProtClustDB	PRK05331.
Enzyme and pathway databases
BioCyc	TSP399726:GHCK-1766-MONOMER.
UniPathway	UPA00085.
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
HAMAP	MF_00019. PlsX.
InterPro	IPR003664. FA_synthesis. IPR024084. IsoPropMal-DH-like_dom. IPR012281. Phospholipid_synth_PlsX-like. [Graphical view]
Pfam	PF02504. FA_synthesis. 1 hit. [Graphical view]
PIRSF	PIRSF002465. Phsphlp_syn_PlsX. 1 hit.
TIGRFAMs	TIGR00182. plsX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLSX_THEPX

Accession

Primary (citable) accession number: B0K1W5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	March 18, 2008
Last modified:	May 29, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program