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B0K1F4

- KITH_THEPX

UniProt

B0K1F4 - KITH_THEPX

Protein

Thymidine kinase

Gene

tdk

Organism
Thermoanaerobacter sp. (strain X514)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei90 – 901Proton acceptorUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi149 – 1491ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation
    Metal bindingi187 – 1871ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 238ATPUniRule annotation
    Nucleotide bindingi89 – 924ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciTSP399726:GHCK-99-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:Teth514_0091
    OrganismiThermoanaerobacter sp. (strain X514)
    Taxonomic identifieri399726 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000002155: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Thymidine kinasePRO_1000095437Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi399726.Teth514_0091.

    Structurei

    3D structure databases

    ProteinModelPortaliB0K1F4.
    SMRiB0K1F4. Positions 3-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiQAICLSC.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0K1F4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIYGSLDHGF IEVIVGPMFS GKSEELIRRI KRAQIAKQKV QVFKPAIDDR    50
    YSIDKVVSHN GTNINAISVV KAFEIIELLE EDTEVIAIDE IQFFDHSIVD 100
    VVREIADLGK RVICAGLDMD FRGEPFGPTP DVMAIAESVD KLTAICVKCG 150
    NPATRTQRLI NGKPAKYDDP IILVGAHETY EARCRKCHEV PRT 193
    Length:193
    Mass (Da):21,525
    Last modified:March 18, 2008 - v1
    Checksum:iC3A1EB55D37A84D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY91413.1.
    RefSeqiYP_001661749.1. NC_010320.1.

    Genome annotation databases

    EnsemblBacteriaiABY91413; ABY91413; Teth514_0091.
    GeneIDi5876968.
    KEGGitex:Teth514_0091.
    PATRICi23889657. VBITheSp86957_0097.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY91413.1 .
    RefSeqi YP_001661749.1. NC_010320.1.

    3D structure databases

    ProteinModelPortali B0K1F4.
    SMRi B0K1F4. Positions 3-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399726.Teth514_0091.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY91413 ; ABY91413 ; Teth514_0091 .
    GeneIDi 5876968.
    KEGGi tex:Teth514_0091.
    PATRICi 23889657. VBITheSp86957_0097.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi QAICLSC.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci TSP399726:GHCK-99-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X514.

    Entry informationi

    Entry nameiKITH_THEPX
    AccessioniPrimary (citable) accession number: B0K1F4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3