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B0K1D0

- PNP_THEPX

UniProt

B0K1D0 - PNP_THEPX

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Teth514_1639
Organism
Thermoanaerobacter sp. (strain X514)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi484 – 4841Magnesium By similarity
Metal bindingi490 – 4901Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciTSP399726:GHCK-1678-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Teth514_1639
OrganismiThermoanaerobacter sp. (strain X514)
Taxonomic identifieri399726 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002155: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 700700Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000382423Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi399726.Teth514_1639.

Structurei

3D structure databases

ProteinModelPortaliB0K1D0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini551 – 61060KH
Add
BLAST
Domaini620 – 68869S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiRRIITHD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0K1D0-1 [UniParc]FASTAAdd to Basket

« Hide

MEERTFEMEL AGRKLLVQIG KVAQQANGAA WVKYGDTVVL VTACASKEPR    50
EGIDFFPLTV EYEERLYSVG KIPGGFIKRE GKPSEKAILS ARLIDRPIRP 100
LFPHGYRNDV QVIATVLSVD PDVQPEIVAM IGSSVALSIS DIPFDGPTGA 150
VAVGLVDGQF IINPNHEQRE KSLMHLVVSG TKDAIVMVEA GAKEVPEETM 200
LDAIMYAHEY IKQIVEFIEG IVKEVGVPKS EVILHEIDKE LEEKVRAYAT 250
EKIYNALRTA EKKERNDNLD KVEQEVLEHF KEEYPDNLAD IDEVLYNIMK 300
EQMRKMITEE RIRVDGRGLD DIRPIWCEVG VLPRTHGSAI FTRGQTQVLT 350
VATLGALGDI QILDGIGDEE AKRYMHHYNF PPYSVGEVRP LRGPGRREIG 400
HGALAERALE PVIPSEEEFP YTIRLVSEVL SSNGSTSQAS VCGSTLALMD 450
AGVPIKAPVA GVAMGLIKEG DVVSVLTDIQ GIEDFLGDMD FKVAGTEKGI 500
TAIQMDIKIP GIDKEILKMA LEKARRGRLY ILSKMLEVIK EPRKQLSVYA 550
PRVIRMVVDP EKIREIIGPG GKTISKIIAE TGVKIDIEED GRLYITASDL 600
RSGERAKQMI EAITKDIAVG EIYLGKVLRI TPFGAFVEIA PGKEGLVHIS 650
KLSKKRVQKV EDVVKVGDDI LVKVTDIDKL GRISLSRKDA LPDEEEEERN 700
Length:700
Mass (Da):77,497
Last modified:March 18, 2008 - v1
Checksum:i6A4559F2393A4A63
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000923 Genomic DNA. Translation: ABY92925.1.
RefSeqiYP_001663261.1. NC_010320.1.

Genome annotation databases

EnsemblBacteriaiABY92925; ABY92925; Teth514_1639.
GeneIDi5877646.
KEGGitex:Teth514_1639.
PATRICi23892940. VBITheSp86957_1701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000923 Genomic DNA. Translation: ABY92925.1 .
RefSeqi YP_001663261.1. NC_010320.1.

3D structure databases

ProteinModelPortali B0K1D0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399726.Teth514_1639.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY92925 ; ABY92925 ; Teth514_1639 .
GeneIDi 5877646.
KEGGi tex:Teth514_1639.
PATRICi 23892940. VBITheSp86957_1701.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi RRIITHD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci TSP399726:GHCK-1678-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X514.

Entry informationi

Entry nameiPNP_THEPX
AccessioniPrimary (citable) accession number: B0K1D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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