B0K0V4 (PPNK_THEPX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	Teth514_1542

Organism

Thermoanaerobacter sp. (strain X514) [Complete proteome] [HAMAP]

Taxonomic identifier

399726 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Thermoanaerobacter

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_1000120895

Sequences

	Sequence		Length	Mass (Da)
	B0K0V4 [UniParc]. Last modified March 18, 2008. Version 1. Checksum: DCC8D88EB7EEE705	FASTA	283	31,908
	10 20 30 40 50 60 MKKVGVIPNI NKDKDLEVTK SVVKWLLEHD SEPYLNEIVA SKMGYDEYGK KSTDIYSKSD 70 80 90 100 110 120 FIIALGGDGT ILNVARLCAP FGTPIFAVNL GHLGFLTEVD MNEVFVSLDK IYKGEYTVEK 130 140 150 160 170 180 RMMLEANVVK NDMEIINFRA LNDIVITRGA FSRMARINAY VNNNYVDTYL ADGVIIATPT 190 200 210 220 230 240 GSTAYSLSAG GPIVYPTVEV IIITPICPHT LYSRSIIVSP DDVIRLEISE ENQDLMITTD 250 260 270 280 GQQGYKLDYR DIIYIKKSNE YTNLIRVKNT NFFDLLRDKL TER

References

[1]

"Complete sequence of Thermoanaerobacter sp. X514." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Hemme C., Fields M.W., He Z., Zhou J., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: X514.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000923 Genomic DNA. Translation: ABY92829.1.
RefSeq	YP_001663165.1. NC_010320.1.
3D structure databases
ProteinModelPortal	B0K0V4.
ModBase	Search...
Protein-protein interaction databases
STRING	B0K0V4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5876728.
GenomeReviews	Gene locus Teth514_1542 in contig CP000923_GR.
KEGG	tex:Teth514_1542.
PATRIC	23892738. VBITheSp86957_1600.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG713904.
OMA	KLGWGLP.
ProtClustDB	CLSK901156.
Enzyme and pathway databases
BioCyc	TSP1755:TETH514_1542-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_THEPX

Accession

Primary (citable) accession number: B0K0V4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	March 18, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program