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B0K0V4

- NADK_THEPX

UniProt

B0K0V4 - NADK_THEPX

Protein

NAD kinase

Gene

nadK

Organism
Thermoanaerobacter sp. (strain X514)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681Proton acceptorUniRule annotation
    Binding sitei153 – 1531NADUniRule annotation
    Binding sitei172 – 1721NADUniRule annotation
    Binding sitei242 – 2421NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 692NADUniRule annotation
    Nucleotide bindingi142 – 1432NADUniRule annotation
    Nucleotide bindingi183 – 1886NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTSP399726:GHCK-1581-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Teth514_1542
    OrganismiThermoanaerobacter sp. (strain X514)
    Taxonomic identifieri399726 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000002155: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283NAD kinasePRO_1000120895Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi399726.Teth514_1542.

    Structurei

    3D structure databases

    ProteinModelPortaliB0K0V4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiRWEALCL.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0K0V4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKVGVIPNI NKDKDLEVTK SVVKWLLEHD SEPYLNEIVA SKMGYDEYGK    50
    KSTDIYSKSD FIIALGGDGT ILNVARLCAP FGTPIFAVNL GHLGFLTEVD 100
    MNEVFVSLDK IYKGEYTVEK RMMLEANVVK NDMEIINFRA LNDIVITRGA 150
    FSRMARINAY VNNNYVDTYL ADGVIIATPT GSTAYSLSAG GPIVYPTVEV 200
    IIITPICPHT LYSRSIIVSP DDVIRLEISE ENQDLMITTD GQQGYKLDYR 250
    DIIYIKKSNE YTNLIRVKNT NFFDLLRDKL TER 283
    Length:283
    Mass (Da):31,908
    Last modified:March 18, 2008 - v1
    Checksum:iDCC8D88EB7EEE705
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY92829.1.
    RefSeqiYP_001663165.1. NC_010320.1.

    Genome annotation databases

    EnsemblBacteriaiABY92829; ABY92829; Teth514_1542.
    GeneIDi5876728.
    KEGGitex:Teth514_1542.
    PATRICi23892738. VBITheSp86957_1600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY92829.1 .
    RefSeqi YP_001663165.1. NC_010320.1.

    3D structure databases

    ProteinModelPortali B0K0V4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 399726.Teth514_1542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY92829 ; ABY92829 ; Teth514_1542 .
    GeneIDi 5876728.
    KEGGi tex:Teth514_1542.
    PATRICi 23892738. VBITheSp86957_1600.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi RWEALCL.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci TSP399726:GHCK-1581-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X514.

    Entry informationi

    Entry nameiNADK_THEPX
    AccessioniPrimary (citable) accession number: B0K0V4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3