B0K0H2 (UPPP_THEPX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	Teth514_1408

Organism

Thermoanaerobacter sp. (strain X514) [Complete proteome] [HAMAP]

Taxonomic identifier

399726 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteraceae › Thermoanaerobacter

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000148834
Regions
	Transmembrane	3 – 23	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	107 – 127	21	Helical; Potential
	Transmembrane	148 – 167	20	Helical; Potential
	Transmembrane	184 – 204	21	Helical; Potential
	Transmembrane	213 – 233	21	Helical; Potential
	Transmembrane	248 – 268	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B0K0H2 [UniParc]. Last modified March 18, 2008. Version 1. Checksum: 1035345E115129A9	FASTA	269	29,735
	10 20 30 40 50 60 MELLIKAFIM GIVEGLTEFL PISSTGHLII VGKFIHFTGN FATMFEIVIQ LGAILAVVFY 70 80 90 100 110 120 YRKKIFASLK NLKPGSWGFN LWFKIFIAFI PAAVIGLLTH KYIEEHLFSP FTVAIALIAG 130 140 150 160 170 180 AIMMIVIEDT FGKRYKIDNM DKVDTKKSLL IGIAQVMSLF PGMSRSASTI MGGMLAGLSV 190 200 210 220 230 240 KAAAEFSFFL AIPTMFAATT LSLLKGFSAM SLLEWQALAV GFITSFLTAL FVVDKFLPYL 250 260 TRHSLKPFAY YRLAVGVLMI LLVAEKIVK

References

[1]

"Complete sequence of Thermoanaerobacter sp. X514." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Hemme C., Fields M.W., He Z., Zhou J., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: X514.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000923 Genomic DNA. Translation: ABY92697.1.
RefSeq	YP_001663033.1. NC_010320.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	399726.Teth514_1408.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABY92697; ABY92697; Teth514_1408.
GeneID	5876026.
KEGG	tex:Teth514_1408.
PATRIC	23892464. VBITheSp86957_1464.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	PERENVT.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	TSP399726:GHCK-1447-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_THEPX

Accession

Primary (citable) accession number: B0K0H2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 18, 2008
Last modified:	May 29, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program