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B0K0D9

- PCP_THEPX

UniProt

B0K0D9 - PCP_THEPX

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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Thermoanaerobacter sp. (strain X514)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781UniRule annotation
Active sitei141 – 1411UniRule annotation
Active sitei165 – 1651UniRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciTSP399726:GHCK-1413-MONOMER.

Protein family/group databases

MEROPSiC15.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidaseUniRule annotation
Pyroglutamyl-peptidase IUniRule annotation
Short name:
PGP-IUniRule annotation
Short name:
PyraseUniRule annotation
Gene namesi
Name:pcpUniRule annotation
Ordered Locus Names:Teth514_1374
OrganismiThermoanaerobacter sp. (strain X514)
Taxonomic identifieri399726 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002155: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytosol Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Pyrrolidone-carboxylate peptidasePRO_1000124007Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi399726.Teth514_1374.

Structurei

3D structure databases

ProteinModelPortaliB0K0D9.
SMRiB0K0D9. Positions 2-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2039.
HOGENOMiHOG000242641.
KOiK01304.
OMAiKPNTPSM.
OrthoDBiEOG6X1124.

Family and domain databases

Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0K0D9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKILVTAFDP FGGENINPSY EVLKNLKDNI EGAEIIKIQV PTVFYLSVEK
60 70 80 90 100
VIEKIKEVKP DAVLSIGQAG GRYDITVERI AINIDDARIP DNIGQQPIDT
110 120 130 140 150
PIDPEGAPAY FATIPIKEIV EEIKKENIPA SISNTAGTFV CNHLMYGILN
160 170 180 190 200
YVHKNGLNIK AGFIHIPYLP VQVLNKPYTP SMSLGDMVKA IETAIKVIAK

KSR
Length:203
Mass (Da):22,357
Last modified:March 18, 2008 - v1
Checksum:i2E57519B137C5337
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000923 Genomic DNA. Translation: ABY92664.1.
RefSeqiYP_001663000.1. NC_010320.1.

Genome annotation databases

EnsemblBacteriaiABY92664; ABY92664; Teth514_1374.
GeneIDi5875675.
KEGGitex:Teth514_1374.
PATRICi23892396. VBITheSp86957_1430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000923 Genomic DNA. Translation: ABY92664.1 .
RefSeqi YP_001663000.1. NC_010320.1.

3D structure databases

ProteinModelPortali B0K0D9.
SMRi B0K0D9. Positions 2-201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 399726.Teth514_1374.

Protein family/group databases

MEROPSi C15.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY92664 ; ABY92664 ; Teth514_1374 .
GeneIDi 5875675.
KEGGi tex:Teth514_1374.
PATRICi 23892396. VBITheSp86957_1430.

Phylogenomic databases

eggNOGi COG2039.
HOGENOMi HOG000242641.
KOi K01304.
OMAi KPNTPSM.
OrthoDBi EOG6X1124.

Enzyme and pathway databases

BioCyci TSP399726:GHCK-1413-MONOMER.

Family and domain databases

Gene3Di 3.40.630.20. 1 hit.
HAMAPi MF_00417. Pyrrolid_peptidase.
InterProi IPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view ]
PANTHERi PTHR23402. PTHR23402. 1 hit.
Pfami PF01470. Peptidase_C15. 1 hit.
[Graphical view ]
PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSi PR00706. PYROGLUPTASE.
TIGRFAMsi TIGR00504. pyro_pdase. 1 hit.
PROSITEi PS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: X514.

Entry informationi

Entry nameiPCP_THEPX
AccessioniPrimary (citable) accession number: B0K0D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 18, 2008
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3