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B0K0D9

- PCP_THEPX

UniProt

B0K0D9 - PCP_THEPX

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Protein
Pyrrolidone-carboxylate peptidase
Gene
pcp, Teth514_1374
Organism
Thermoanaerobacter sp. (strain X514)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781 By similarity
Active sitei141 – 1411 By similarity
Active sitei165 – 1651 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciTSP399726:GHCK-1413-MONOMER.

    Protein family/group databases

    MEROPSiC15.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
    Alternative name(s):
    5-oxoprolyl-peptidase
    Pyroglutamyl-peptidase I
    Short name:
    PGP-I
    Short name:
    Pyrase
    Gene namesi
    Name:pcp
    Ordered Locus Names:Teth514_1374
    OrganismiThermoanaerobacter sp. (strain X514)
    Taxonomic identifieri399726 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000002155: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Pyrrolidone-carboxylate peptidaseUniRule annotation
    PRO_1000124007Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi399726.Teth514_1374.

    Structurei

    3D structure databases

    ProteinModelPortaliB0K0D9.
    SMRiB0K0D9. Positions 2-201.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiKPNTPSM.
    OrthoDBiEOG6X1124.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0K0D9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILVTAFDP FGGENINPSY EVLKNLKDNI EGAEIIKIQV PTVFYLSVEK    50
    VIEKIKEVKP DAVLSIGQAG GRYDITVERI AINIDDARIP DNIGQQPIDT 100
    PIDPEGAPAY FATIPIKEIV EEIKKENIPA SISNTAGTFV CNHLMYGILN 150
    YVHKNGLNIK AGFIHIPYLP VQVLNKPYTP SMSLGDMVKA IETAIKVIAK 200
    KSR 203
    Length:203
    Mass (Da):22,357
    Last modified:March 18, 2008 - v1
    Checksum:i2E57519B137C5337
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY92664.1.
    RefSeqiYP_001663000.1. NC_010320.1.

    Genome annotation databases

    EnsemblBacteriaiABY92664; ABY92664; Teth514_1374.
    GeneIDi5875675.
    KEGGitex:Teth514_1374.
    PATRICi23892396. VBITheSp86957_1430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000923 Genomic DNA. Translation: ABY92664.1 .
    RefSeqi YP_001663000.1. NC_010320.1.

    3D structure databases

    ProteinModelPortali B0K0D9.
    SMRi B0K0D9. Positions 2-201.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 399726.Teth514_1374.

    Protein family/group databases

    MEROPSi C15.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY92664 ; ABY92664 ; Teth514_1374 .
    GeneIDi 5875675.
    KEGGi tex:Teth514_1374.
    PATRICi 23892396. VBITheSp86957_1430.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi KPNTPSM.
    OrthoDBi EOG6X1124.

    Enzyme and pathway databases

    BioCyci TSP399726:GHCK-1413-MONOMER.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: X514.

    Entry informationi

    Entry nameiPCP_THEPX
    AccessioniPrimary (citable) accession number: B0K0D9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: March 18, 2008
    Last modified: September 3, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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