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Protein

CDGSH iron-sulfur domain-containing protein 1

Gene

Cisd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions.By similarity

Cofactori

[2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit. The [2Fe-2S] cluster is redox-active and pH labile and is significantly less stable at pH 4.5 as compared with pH 7.0.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi72Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi74Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi83Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi87Iron-sulfur (2Fe-2S); via pros nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CDGSH iron-sulfur domain-containing protein 1
Alternative name(s):
MitoNEET
Gene namesi
Name:Cisd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1309529 Cisd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 31Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST19
Topological domaini32 – 108CytoplasmicSequence analysisAdd BLAST77

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547051 – 108CDGSH iron-sulfur domain-containing protein 1Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei55N6-acetyllysine; alternateBy similarity1
Cross-linki55Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residuei68N6-acetyllysine; alternateBy similarity1
Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki79Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki89Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei104N6-acetyllysine; alternateBy similarity1
Cross-linki104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki105Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiB0K020
PeptideAtlasiB0K020
PRIDEiB0K020

PTM databases

CarbonylDBiB0K020
iPTMnetiB0K020
PhosphoSitePlusiB0K020
SwissPalmiB0K020

Expressioni

Gene expression databases

BgeeiENSRNOG00000000610
GenevisibleiB0K020 RN

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000749

Structurei

3D structure databases

ProteinModelPortaliB0K020
SMRiB0K020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CISD protein family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3461 Eukaryota
ENOG41122II LUCA
GeneTreeiENSGT00390000001233
HOGENOMiHOG000242301
HOVERGENiHBG052444
InParanoidiB0K020
OMAiKDHRNKS
OrthoDBiEOG091G0XB4
PhylomeDBiB0K020
TreeFamiTF324661

Family and domain databases

InterProiView protein in InterPro
IPR018967 FeS-contain_CDGSH-typ
IPR019610 FeS-contain_mitoNEET_N
PfamiView protein in Pfam
PF10660 MitoNEET_N, 1 hit
PF09360 zf-CDGSH, 1 hit
SMARTiView protein in SMART
SM00704 ZnF_CDGSH, 1 hit

Sequencei

Sequence statusi: Complete.

B0K020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSSDSPVR VEWIAAVTFA AGTAALGYLA YKKFYAKESR TKAMVNLQIQ
60 70 80 90 100
KDNPKVVHAF DMEDLGDKAV YCRCWRSKKF PFCDGAHIKH NEETGDNVGP

LIIKKKET
Length:108
Mass (Da):12,097
Last modified:March 18, 2008 - v1
Checksum:i72B2548F490E5FA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473988 Genomic DNA Translation: EDL97255.1
BC159419 mRNA Translation: AAI59420.1
RefSeqiNP_001099855.1, NM_001106385.2
UniGeneiRn.1164

Genome annotation databases

EnsembliENSRNOT00000000749; ENSRNOP00000000749; ENSRNOG00000000610
GeneIDi294362
KEGGirno:294362
UCSCiRGD:1309529 rat

Similar proteinsi

Entry informationi

Entry nameiCISD1_RAT
AccessioniPrimary (citable) accession number: B0K020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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