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Protein

BAG family molecular chaperone regulator 1

Gene

Bag1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli (By similarity).By similarity

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: RGD
  • response to drug Source: RGD
  • response to lithium ion Source: RGD
  • response to nicotine Source: RGD
  • response to organic cyclic compound Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 1
Short name:
BAG-1
Alternative name(s):
Bcl-2-associated athanogene 1
Gene namesi
Name:Bag1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305203. Bag1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • mitochondrion Source: RGD
  • nucleus Source: RGD
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358BAG family molecular chaperone regulator 1PRO_0000389100Add
BLAST

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiB0K019.
PeptideAtlasiB0K019.
PRIDEiB0K019.

PTM databases

iPTMnetiB0K019.
PhosphoSiteiB0K019.

Interactioni

Subunit structurei

Homodimer. Forms a heteromeric complex with HSP70/HSC70. Binds to the ATPase domain of HSP/HSC70 chaperones. Interacts with NR3C1. Interacts with the N-terminal region of STK19. Interacts with PPP1R15A. Interacts with BCL2 in an ATP-dependent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi255722. 6 interactions.
DIPiDIP-60384N.
STRINGi10116.ENSRNOP00000011455.

Structurei

3D structure databases

ProteinModelPortaliB0K019.
SMRiB0K019. Positions 157-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati102 – 111101
Repeati114 – 11962
Repeati120 – 12563
Repeati126 – 13164
Repeati132 – 13765
Repeati144 – 14966
Repeati150 – 15567
Domaini157 – 23781Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST
Domaini259 – 33981BAGPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni114 – 212997 X 6 AA tandem repeat of E-E-X(4)Add
BLAST
Regioni185 – 23248Interaction with HSPA8By similarityAdd
BLAST
Regioni229 – 358130Interaction with PPP1R15ABy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 BAG domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHYI. Eukaryota.
ENOG4111SUG. LUCA.
HOGENOMiHOG000286009.
HOVERGENiHBG000236.
InParanoidiB0K019.
KOiK09555.
PhylomeDBiB0K019.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiIPR003103. BAG_domain.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF63491. SSF63491. 1 hit.
PROSITEiPS51035. BAG. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0K019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRGGARRP RGDQEPLGPR LRAPRSARET RQSESRAERG LPPSQRSSVR
60 70 80 90 100
SAASGHDRST RGAASGACKP RVKKKVRPRS SQSEKVAHSK ELTRSKKLTR
110 120 130 140 150
SKKVTGTQEA TQVEEVTTIE EATQTEEITV AEEVTQTENM AQTEEMVQTE
160 170 180 190 200
EMEPPTLSVV VTHSNERYDL LVTPQQGNSE PIVQDLAQLV EEATGVPLPF
210 220 230 240 250
QKLIFKGKSL KEMETPLSAL GMQNGCRVML IGEKSNPEEE AELKKLKDLE
260 270 280 290 300
VSVEKTANHL EELNKELSDI QQGFLAKELQ AEALCRLDRK IKATIEQFMK
310 320 330 340 350
ILEEIDTMVL PENFKDSRLK RKNLVKKVQV FLAECDTVEQ YICQETERLQ

STNLALPE
Length:358
Mass (Da):40,160
Last modified:March 18, 2008 - v1
Checksum:i7C39247930E3E198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC159418 mRNA. Translation: AAI59419.1.
RefSeqiNP_001100117.2. NM_001106647.3.
NP_001243013.1. NM_001256084.1.
UniGeneiRn.16320.

Genome annotation databases

GeneIDi297994.
KEGGirno:297994.
UCSCiRGD:1305203. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC159418 mRNA. Translation: AAI59419.1.
RefSeqiNP_001100117.2. NM_001106647.3.
NP_001243013.1. NM_001256084.1.
UniGeneiRn.16320.

3D structure databases

ProteinModelPortaliB0K019.
SMRiB0K019. Positions 157-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi255722. 6 interactions.
DIPiDIP-60384N.
STRINGi10116.ENSRNOP00000011455.

PTM databases

iPTMnetiB0K019.
PhosphoSiteiB0K019.

Proteomic databases

PaxDbiB0K019.
PeptideAtlasiB0K019.
PRIDEiB0K019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi297994.
KEGGirno:297994.
UCSCiRGD:1305203. rat.

Organism-specific databases

CTDi573.
RGDi1305203. Bag1.

Phylogenomic databases

eggNOGiENOG410IHYI. Eukaryota.
ENOG4111SUG. LUCA.
HOGENOMiHOG000286009.
HOVERGENiHBG000236.
InParanoidiB0K019.
KOiK09555.
PhylomeDBiB0K019.

Miscellaneous databases

PROiB0K019.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiIPR003103. BAG_domain.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF63491. SSF63491. 1 hit.
PROSITEiPS51035. BAG. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAG1_RAT
AccessioniPrimary (citable) accession number: B0K019
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: March 18, 2008
Last modified: September 7, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.