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Protein

BAG family molecular chaperone regulator 1

Gene

Bag1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.By similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: RGD
  • positive regulation of Schwann cell differentiation Source: RGD
  • response to drug Source: RGD
  • response to lithium ion Source: RGD
  • response to nicotine Source: RGD
  • response to organic cyclic compound Source: RGD

Keywordsi

Molecular functionChaperone
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 1
Short name:
BAG-1
Alternative name(s):
Bcl-2-associated athanogene 1
Gene namesi
Name:Bag1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305203 Bag1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003891001 – 358BAG family molecular chaperone regulator 1Add BLAST358

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiB0K019
PeptideAtlasiB0K019

PTM databases

iPTMnetiB0K019
PhosphoSitePlusiB0K019

Interactioni

Subunit structurei

Homodimer. Forms a heteromeric complex with HSP70/HSC70. Binds to the ATPase domain of HSP/HSC70 chaperones. Interacts with NR3C1. Interacts with the N-terminal region of STK19. Interacts with PPP1R15A. Interacts with BCL2 in an ATP-dependent manner. Interacts with SIAH1, SIAH2, HSPA8 (via NBD), HSPA1A (via NBD) and HSPA1B (via NBD).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi255722, 6 interactors
DIPiDIP-60384N
IntActiB0K019, 2 interactors
STRINGi10116.ENSRNOP00000011455

Structurei

3D structure databases

ProteinModelPortaliB0K019
SMRiB0K019
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati102 – 111110
Repeati114 – 11926
Repeati120 – 12536
Repeati126 – 13146
Repeati132 – 13756
Repeati144 – 14966
Repeati150 – 15576
Domaini157 – 237Ubiquitin-likePROSITE-ProRule annotationAdd BLAST81
Domaini259 – 339BAGPROSITE-ProRule annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni114 – 2127 X 6 AA tandem repeat of E-E-X(4)Add BLAST99
Regioni185 – 232Interaction with HSPA8By similarityAdd BLAST48
Regioni229 – 358Interaction with PPP1R15ABy similarityAdd BLAST130

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHYI Eukaryota
ENOG4111SUG LUCA
HOGENOMiHOG000286009
HOVERGENiHBG000236
InParanoidiB0K019
KOiK09555
PhylomeDBiB0K019

Family and domain databases

Gene3Di1.20.58.120, 1 hit
InterProiView protein in InterPro
IPR017093 BAG-1
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR12329:SF16 PTHR12329:SF16, 1 hit
PfamiView protein in Pfam
PF02179 BAG, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF63491 SSF63491, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

B0K019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRGGARRP RGDQEPLGPR LRAPRSARET RQSESRAERG LPPSQRSSVR
60 70 80 90 100
SAASGHDRST RGAASGACKP RVKKKVRPRS SQSEKVAHSK ELTRSKKLTR
110 120 130 140 150
SKKVTGTQEA TQVEEVTTIE EATQTEEITV AEEVTQTENM AQTEEMVQTE
160 170 180 190 200
EMEPPTLSVV VTHSNERYDL LVTPQQGNSE PIVQDLAQLV EEATGVPLPF
210 220 230 240 250
QKLIFKGKSL KEMETPLSAL GMQNGCRVML IGEKSNPEEE AELKKLKDLE
260 270 280 290 300
VSVEKTANHL EELNKELSDI QQGFLAKELQ AEALCRLDRK IKATIEQFMK
310 320 330 340 350
ILEEIDTMVL PENFKDSRLK RKNLVKKVQV FLAECDTVEQ YICQETERLQ

STNLALPE
Length:358
Mass (Da):40,160
Last modified:March 18, 2008 - v1
Checksum:i7C39247930E3E198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC159418 mRNA Translation: AAI59419.1
RefSeqiNP_001100117.2, NM_001106647.3
NP_001243013.1, NM_001256084.1
UniGeneiRn.16320

Genome annotation databases

GeneIDi297994
KEGGirno:297994
UCSCiRGD:1305203 rat

Similar proteinsi

Entry informationi

Entry nameiBAG1_RAT
AccessioniPrimary (citable) accession number: B0K019
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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