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Protein

Calmodulin-lysine N-methyltransferase

Gene

Camkmt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the trimethylation of 'Lys-116' in calmodulin.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine.PROSITE-ProRule annotation2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-lysine N-methyltransferase (EC:2.1.1.60)
Short name:
CLNMT
Short name:
CaM KMT
Gene namesi
Name:Camkmt
Synonyms:Clnmt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310453 Camkmt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004037861 – 323Calmodulin-lysine N-methyltransferaseAdd BLAST323

Proteomic databases

PaxDbiB0K012
PRIDEiB0K012

Expressioni

Gene expression databases

GenevisibleiB0K012 RN

Interactioni

Subunit structurei

Monomer (Probable). Interacts with HSP90, probably as a client (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048187

Structurei

3D structure databases

ProteinModelPortaliB0K012
SMRiB0K012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3201 Eukaryota
ENOG4110DEX LUCA
HOGENOMiHOG000006662
HOVERGENiHBG105701
InParanoidiB0K012
KOiK18826
OrthoDBiEOG091G0FGE
PhylomeDBiB0K012
TreeFamiTF316589

Family and domain databases

InterProiView protein in InterPro
IPR025800 CaM-Lys-N-MeTrfase
IPR019410 Methyltransf_16
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10294 Methyltransf_16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51610 SAM_CLNMT, 1 hit

Sequencei

Sequence statusi: Complete.

B0K012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESQVAVAGD GETEAEAGKG PMIDSASQGS LVSAPKGAVR WKLLRQVLKQ
60 70 80 90 100
KQLDDGLRHV SVRRFESFNL FSVTEAKNRG TEKEAGAWVQ YTSIFYPEYS
110 120 130 140 150
ISLRRNSGSL SVEDVLTSFD NTGNVCIWPS EEVLAYYCLK HSHLFRDLAV
160 170 180 190 200
CELGGGMTCL AGLMVAISAD VKEVLLTDGN EKAIRNVNSI IASNKKTGVF
210 220 230 240 250
KTQKISSCVL RWDNKTDVSQ LEGHFDIVMC ADCLFLDQYR ASLVDAIKRL
260 270 280 290 300
LQPSGKALVF APRRGNTFNQ FCNLAEKAGL SLQRHENYDE RISNFHSKLK
310 320
KEGSDVYEEN LHYPLLLILT KTG
Length:323
Mass (Da):35,883
Last modified:March 18, 2008 - v1
Checksum:i3A34ED60C4038F1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC159411 mRNA Translation: AAI59412.1
CH473947 Genomic DNA Translation: EDM02674.1
RefSeqiNP_001127935.1, NM_001134463.1
UniGeneiRn.12129

Genome annotation databases

GeneIDi299521
KEGGirno:299521
UCSCiRGD:1310453 rat

Similar proteinsi

Entry informationi

Entry nameiCMKMT_RAT
AccessioniPrimary (citable) accession number: B0K012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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