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Protein

Calmodulin-lysine N-methyltransferase

Gene

Camkmt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the trimethylation of 'Lys-116' in calmodulin.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine.PROSITE-ProRule annotation2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-lysine N-methyltransferase (EC:2.1.1.60)
Short name:
CLNMT
Short name:
CaM KMT
Gene namesi
Name:Camkmt
Synonyms:Clnmt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310453. Camkmt.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004037861 – 323Calmodulin-lysine N-methyltransferaseAdd BLAST323

Proteomic databases

PaxDbiB0K012.
PRIDEiB0K012.

Expressioni

Gene expression databases

GenevisibleiB0K012. RN.

Interactioni

Subunit structurei

Monomer (Probable). Interacts with HSP90, probably as a client (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048187.

Structurei

3D structure databases

ProteinModelPortaliB0K012.
SMRiB0K012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3201. Eukaryota.
ENOG4110DEX. LUCA.
HOGENOMiHOG000006662.
HOVERGENiHBG105701.
InParanoidiB0K012.
KOiK18826.
OrthoDBiEOG091G0FGE.
PhylomeDBiB0K012.
TreeFamiTF316589.

Family and domain databases

InterProiView protein in InterPro
IPR025800. CaM-Lys-N-MeTrfase.
IPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF10294. Methyltransf_16. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS51610. SAM_CLNMT. 1 hit.

Sequencei

Sequence statusi: Complete.

B0K012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESQVAVAGD GETEAEAGKG PMIDSASQGS LVSAPKGAVR WKLLRQVLKQ
60 70 80 90 100
KQLDDGLRHV SVRRFESFNL FSVTEAKNRG TEKEAGAWVQ YTSIFYPEYS
110 120 130 140 150
ISLRRNSGSL SVEDVLTSFD NTGNVCIWPS EEVLAYYCLK HSHLFRDLAV
160 170 180 190 200
CELGGGMTCL AGLMVAISAD VKEVLLTDGN EKAIRNVNSI IASNKKTGVF
210 220 230 240 250
KTQKISSCVL RWDNKTDVSQ LEGHFDIVMC ADCLFLDQYR ASLVDAIKRL
260 270 280 290 300
LQPSGKALVF APRRGNTFNQ FCNLAEKAGL SLQRHENYDE RISNFHSKLK
310 320
KEGSDVYEEN LHYPLLLILT KTG
Length:323
Mass (Da):35,883
Last modified:March 18, 2008 - v1
Checksum:i3A34ED60C4038F1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC159411 mRNA. Translation: AAI59412.1.
CH473947 Genomic DNA. Translation: EDM02674.1.
RefSeqiNP_001127935.1. NM_001134463.1.
UniGeneiRn.12129.

Genome annotation databases

GeneIDi299521.
KEGGirno:299521.
UCSCiRGD:1310453. rat.

Similar proteinsi

Entry informationi

Entry nameiCMKMT_RAT
AccessioniPrimary (citable) accession number: B0K012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 18, 2008
Last modified: August 30, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families