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Protein

Calmodulin-lysine N-methyltransferase

Gene

Camkmt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the trimethylation of 'Lys-116' in calmodulin.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N(6)-methyl-L-lysine.PROSITE-ProRule annotation2 Publications

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-lysine N-methyltransferase (EC:2.1.1.60)
Short name:
CLNMT
Short name:
CaM KMT
Gene namesi
Name:Camkmt
Synonyms:Clnmt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310453. Camkmt.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Calmodulin-lysine N-methyltransferasePRO_0000403786Add
BLAST

Proteomic databases

PaxDbiB0K012.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030629.
GenevisibleiB0K012. RN.

Interactioni

Subunit structurei

Monomer (Probable). Interacts with HSP90, probably as a client (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048187.

Structurei

3D structure databases

ProteinModelPortaliB0K012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3201. Eukaryota.
ENOG4110DEX. LUCA.
HOGENOMiHOG000006662.
HOVERGENiHBG105701.
InParanoidiB0K012.
KOiK18826.
OrthoDBiEOG091G0FGE.
PhylomeDBiB0K012.
TreeFamiTF316589.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025800. CaM-Lys-N-MeTrfase.
IPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51610. SAM_CLNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0K012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESQVAVAGD GETEAEAGKG PMIDSASQGS LVSAPKGAVR WKLLRQVLKQ
60 70 80 90 100
KQLDDGLRHV SVRRFESFNL FSVTEAKNRG TEKEAGAWVQ YTSIFYPEYS
110 120 130 140 150
ISLRRNSGSL SVEDVLTSFD NTGNVCIWPS EEVLAYYCLK HSHLFRDLAV
160 170 180 190 200
CELGGGMTCL AGLMVAISAD VKEVLLTDGN EKAIRNVNSI IASNKKTGVF
210 220 230 240 250
KTQKISSCVL RWDNKTDVSQ LEGHFDIVMC ADCLFLDQYR ASLVDAIKRL
260 270 280 290 300
LQPSGKALVF APRRGNTFNQ FCNLAEKAGL SLQRHENYDE RISNFHSKLK
310 320
KEGSDVYEEN LHYPLLLILT KTG
Length:323
Mass (Da):35,883
Last modified:March 18, 2008 - v1
Checksum:i3A34ED60C4038F1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC159411 mRNA. Translation: AAI59412.1.
CH473947 Genomic DNA. Translation: EDM02674.1.
RefSeqiNP_001127935.1. NM_001134463.1.
UniGeneiRn.12129.

Genome annotation databases

GeneIDi299521.
KEGGirno:299521.
UCSCiRGD:1310453. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC159411 mRNA. Translation: AAI59412.1.
CH473947 Genomic DNA. Translation: EDM02674.1.
RefSeqiNP_001127935.1. NM_001134463.1.
UniGeneiRn.12129.

3D structure databases

ProteinModelPortaliB0K012.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048187.

Proteomic databases

PaxDbiB0K012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi299521.
KEGGirno:299521.
UCSCiRGD:1310453. rat.

Organism-specific databases

CTDi79823.
RGDi1310453. Camkmt.

Phylogenomic databases

eggNOGiKOG3201. Eukaryota.
ENOG4110DEX. LUCA.
HOGENOMiHOG000006662.
HOVERGENiHBG105701.
InParanoidiB0K012.
KOiK18826.
OrthoDBiEOG091G0FGE.
PhylomeDBiB0K012.
TreeFamiTF316589.

Miscellaneous databases

PROiB0K012.

Gene expression databases

BgeeiENSRNOG00000030629.
GenevisibleiB0K012. RN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025800. CaM-Lys-N-MeTrfase.
IPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51610. SAM_CLNMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCMKMT_RAT
AccessioniPrimary (citable) accession number: B0K012
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 18, 2008
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.