Angiotensin-converting enzyme

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• carboxypeptidase activity Source: UniProtKB-KW
• metal ion binding Source: UniProtKB-KW
• metallopeptidase activity Source: UniProtKB-KW
• peptidyl-dipeptidase activity Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MRVLLLGLLL LVGTNSALDS SFLPGTYPKD EAGARDFADA YNSTAEVILF 
        60         70         80         90        100
KSVEASWAYN TNLTDYNSKQ QILASMEEQE FNEAWGMKAK ELFNDVWENF 
       110        120        130        140        150
TDPLLKKIIS SIRTLGASNL NLTAREEYNT ILSEMDSIYS TAKVCPPNAT 
       160        170        180        190        200
AKCWSLEPEI TEIMATSRSY KKLLYAWEGW HNSAGIPLKE KYLRFVQLSN 
       210        220        230        240        250
EAYRMDGYKD TGAYWRSWYA SPTFEEDLDG LYQQLEPLYL NLHAFVRRKL 
       260        270        280        290        300
YERYGAKYIN LKGPIPAHLF GNMWSQQWNN IYDMMIPFPD KTNIDVTNTM 
       310        320        330        340        350
REKGWNATHM FRVSEEFFTS LGLLEMPPEF WEKSMLEKPA DGREVVCHAS 
       360        370        380        390        400
AWDFYNRKDF RIKQCTTVTM EQLFTVHHEM GHVEYYLQYK DQPVTYRRGA 
       410        420        430        440        450
NPGFHEAIGD VLSLSVSTPG HLKTIGLLET VTNDKESDIN YLLKMALEKI 
       460        470        480        490        500
AFLPFGFLID QWRWNVFSGR TPPTRYNYDW WNLRTKYQGI CPPISRDDNQ 
       510        520        530        540        550
FDAGAKYHIP GNTPYIRYFV SFVLQFQFHK ALCTAAKHTG PLHTCDIYRS 
       560        570        580        590        600
QEAGKILGDV LRSGSSKSWQ EVLKDMTGSE KMDVGPLLEY FTPVTQWLIE 
       610        620        630        640        650
QNTKNNEILG WPDFSWTPPM PDGYPGDIEK IANEKEADTF LSDYTKSAEV 
       660        670        680        690        700
VWNDYTEASW AYNTNITEAN KQVMLDKNLA MSGHTLQYGL QARNYDYSDF 
       710        720        730        740        750
QDPETQRILR KLSEIDKAAL SEEEQKEYNQ ITSDMETIYS VAKVCKDGNT 
       760        770        780        790        800
NCHPLDPDLT EILAKSRDYD ELLFAWKGWR DASGKQIREK YKRYVQLANK 
       810        820        830        840        850
AAQLNGYNDN GAYWRSWYET PTLESDVEKL YDELQPLYLN LHAYVRRALY 
       860        870        880        890        900
KKYGDKRINL KGPIPAHLLG NMWAQSWSNI YELLVPYPNA AQVDATPAMI 
       910        920        930        940        950
AKNWTPKRMF EESDNFFKSL GLLPMPQEFW DKSMIEKPKD REVVCHASAW 
       960        970        980        990       1000
DFYNRKDFRI KQCTVVNMDD LITVHHEMGH VQYFLQYKDQ PILFREGANP 
      1010       1020       1030       1040       1050
GFHEAIGDVL ALSVSTPKHL QSIGLLDKVE DNPESDINYL MSIALDKIAF 
      1060       1070       1080       1090       1100
LPFGFLMDQW RWKVFDGRTP DSEYNQQWWN LRLKYQGLVP PVLRTENDFD 
      1110       1120       1130       1140       1150
PGAKFHIPAS VPYIRYFISF VIQFQFHEAL CKAANQEGPL HKCDIYQSTQ 
      1160       1170       1180       1190       1200
AGKLLGDAMK LGNSKPWPEA MQTITGQRNM SAHALLKYFQ PLTDWLIKEN 
      1210       1220       1230       1240       1250
TKNGETLGWP EYNWSPVQSV PLPPSGDSNS DFLGLAVSNS QAAAGQWILL 
      1260       1270       1280 
ALGIVLIITT IVFGVLYSKM KSRAKMSSSQ MELK                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ