ace

Functionⁱ

Cofactorⁱ

Zn²⁺UniRule annotationNote: Binds 2 Zn²⁺ ions per subunit.UniRule annotation

GO - Molecular functionⁱ

carboxypeptidase activity Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
metallopeptidase activity Source: UniProtKB-KW
peptidyl-dipeptidase activity Source: InterPro

Keywordsⁱ

Molecular function	CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
Ligand	Metal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M02.001.

MEROPSⁱ

M02.001.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Angiotensin-converting enzymeUniRule annotation (EC:3.4.-.-UniRule annotation)
Gene namesⁱ	Name:aceImported
Organismⁱ	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifierⁱ	8364 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Organism-specific databases

Xenbaseⁱ	XB-GENE-479789. ace.

Xenbaseⁱ

XB-GENE-479789. ace.

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	1247 – 1267	HelicalSequence analysisAdd BLAST		21

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_5002750879	18 – 1284	Angiotensin-converting enzymeSequence analysisAdd BLAST		1267

Keywords - PTMⁱ

GlycoproteinUniRule annotation

Proteomic databases

PaxDbⁱ	B0JZU8.

PaxDbⁱ

B0JZU8.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B0JZU8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase M2 family.UniRule annotation

Keywords - Domainⁱ

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3690. Eukaryota. ENOG410XPJ3. LUCA.
HOGENOMⁱ	HOG000007838.
HOVERGENⁱ	HBG000264.
KEGG Orthology (KO) More...KOⁱ	K01283.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06461. M2_ACE. 2 hits.
InterProⁱ	View protein in InterPro IPR001548. Peptidase_M2.
PANTHERⁱ	PTHR10514. PTHR10514. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01401. Peptidase_M2. 2 hits.
PRINTSⁱ	PR00791. PEPDIPTASEA.

Sequenceⁱ

Sequence statusⁱ: Complete.

B0JZU8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRVLLLGLLL LVGTNSALDS SFLPGTYPKD EAGARDFADA YNSTAEVILF 
        60         70         80         90        100
KSVEASWAYN TNLTDYNSKQ QILASMEEQE FNEAWGMKAK ELFNDVWENF 
       110        120        130        140        150
TDPLLKKIIS SIRTLGASNL NLTAREEYNT ILSEMDSIYS TAKVCPPNAT 
       160        170        180        190        200
AKCWSLEPEI TEIMATSRSY KKLLYAWEGW HNSAGIPLKE KYLRFVQLSN 
       210        220        230        240        250
EAYRMDGYKD TGAYWRSWYA SPTFEEDLDG LYQQLEPLYL NLHAFVRRKL 
       260        270        280        290        300
YERYGAKYIN LKGPIPAHLF GNMWSQQWNN IYDMMIPFPD KTNIDVTNTM 
       310        320        330        340        350
REKGWNATHM FRVSEEFFTS LGLLEMPPEF WEKSMLEKPA DGREVVCHAS 
       360        370        380        390        400
AWDFYNRKDF RIKQCTTVTM EQLFTVHHEM GHVEYYLQYK DQPVTYRRGA 
       410        420        430        440        450
NPGFHEAIGD VLSLSVSTPG HLKTIGLLET VTNDKESDIN YLLKMALEKI 
       460        470        480        490        500
AFLPFGFLID QWRWNVFSGR TPPTRYNYDW WNLRTKYQGI CPPISRDDNQ 
       510        520        530        540        550
FDAGAKYHIP GNTPYIRYFV SFVLQFQFHK ALCTAAKHTG PLHTCDIYRS 
       560        570        580        590        600
QEAGKILGDV LRSGSSKSWQ EVLKDMTGSE KMDVGPLLEY FTPVTQWLIE 
       610        620        630        640        650
QNTKNNEILG WPDFSWTPPM PDGYPGDIEK IANEKEADTF LSDYTKSAEV 
       660        670        680        690        700
VWNDYTEASW AYNTNITEAN KQVMLDKNLA MSGHTLQYGL QARNYDYSDF 
       710        720        730        740        750
QDPETQRILR KLSEIDKAAL SEEEQKEYNQ ITSDMETIYS VAKVCKDGNT 
       760        770        780        790        800
NCHPLDPDLT EILAKSRDYD ELLFAWKGWR DASGKQIREK YKRYVQLANK 
       810        820        830        840        850
AAQLNGYNDN GAYWRSWYET PTLESDVEKL YDELQPLYLN LHAYVRRALY 
       860        870        880        890        900
KKYGDKRINL KGPIPAHLLG NMWAQSWSNI YELLVPYPNA AQVDATPAMI 
       910        920        930        940        950
AKNWTPKRMF EESDNFFKSL GLLPMPQEFW DKSMIEKPKD REVVCHASAW 
       960        970        980        990       1000
DFYNRKDFRI KQCTVVNMDD LITVHHEMGH VQYFLQYKDQ PILFREGANP 
      1010       1020       1030       1040       1050
GFHEAIGDVL ALSVSTPKHL QSIGLLDKVE DNPESDINYL MSIALDKIAF 
      1060       1070       1080       1090       1100
LPFGFLMDQW RWKVFDGRTP DSEYNQQWWN LRLKYQGLVP PVLRTENDFD 
      1110       1120       1130       1140       1150
PGAKFHIPAS VPYIRYFISF VIQFQFHEAL CKAANQEGPL HKCDIYQSTQ 
      1160       1170       1180       1190       1200
AGKLLGDAMK LGNSKPWPEA MQTITGQRNM SAHALLKYFQ PLTDWLIKEN 
      1210       1220       1230       1240       1250
TKNGETLGWP EYNWSPVQSV PLPPSGDSNS DFLGLAVSNS QAAAGQWILL 
      1260       1270       1280 
ALGIVLIITT IVFGVLYSKM KSRAKMSSSQ MELK

Length:1,284

Mass (Da):148,040

Last modified:March 18, 2008 - v1

Checksum:ⁱ81BE5E5F44FDF291

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC159326 mRNA. Translation: AAI59327.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001116882.1. NM_001123410.1.
UniGeneⁱ	Str.34053.

Genome annotation databases

GeneIDⁱ	100144634.
KEGGⁱ	xtr:100144634.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC159326 mRNA. Translation: AAI59327.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001116882.1. NM_001123410.1.
UniGeneⁱ	Str.34053.

3D structure databases

ProteinModelPortalⁱ	B0JZU8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M02.001.

MEROPSⁱ

M02.001.

Proteomic databases

PaxDbⁱ	B0JZU8.

PaxDbⁱ

B0JZU8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	100144634.
KEGGⁱ	xtr:100144634.

Organism-specific databases

CTDⁱ	1636.
Xenbaseⁱ	XB-GENE-479789. ace.

Phylogenomic databases

eggNOGⁱ	KOG3690. Eukaryota. ENOG410XPJ3. LUCA.
HOGENOMⁱ	HOG000007838.
HOVERGENⁱ	HBG000264.
KEGG Orthology (KO) More...KOⁱ	K01283.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06461. M2_ACE. 2 hits.
InterProⁱ	View protein in InterPro IPR001548. Peptidase_M2.
PANTHERⁱ	PTHR10514. PTHR10514. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01401. Peptidase_M2. 2 hits.
PRINTSⁱ	PR00791. PEPDIPTASEA.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B0JZU8_XENTR
Accessionⁱ	B0JZU8Primary (citable) accession number: B0JZU8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 18, 2008
	Last sequence update:	March 18, 2008
	Last modified:	July 5, 2017
	This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B0JZU8 (B0JZU8_XENTR)

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Angiotensin-converting enzyme

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ