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B0JYC3

- PNP_MICAN

UniProt

B0JYC3 - PNP_MICAN

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, MAE_53390
Organism
Microcystis aeruginosa (strain NIES-843)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi496 – 4961Magnesium By similarity
Metal bindingi502 – 5021Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMAER449447:GHO8-5382-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:MAE_53390
OrganismiMicrocystis aeruginosa (strain NIES-843)
Taxonomic identifieri449447 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesMicrocystis
ProteomesiUP000001510: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_1000087992Add
BLAST

Proteomic databases

PaxDbiB0JYC3.
PRIDEiB0JYC3.

Interactioni

Protein-protein interaction databases

STRINGi449447.MAE_53390.

Structurei

3D structure databases

ProteinModelPortaliB0JYC3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini563 – 62260KHAdd
BLAST
Domaini632 – 70069S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0JYC3-1 [UniParc]FASTAAdd to Basket

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MEEFDKSISF DGRDIRLKIG LLAPQAGGSV LIQSGETAVL VTATTAKARE    50
GVDFLPLTVD YEERLYAAGR IPGGFLRREG RPPEKAILTG RLIDRPLRPL 100
FPNWMRDDIQ VVATTLSMDE EVPPDVLAVT GASVAVLLAG IPFQGPMAAV 150
RVGLLGDEFI INPTYKEIHN GELDLVVAGS PEGVVMIEAG ANQLPERDII 200
EAIDFGYEAV RDLITAQREL IDQLGIPLVT REAPAVNETV QNFLREQAKE 250
EIKQILSQFT LSKTERDEKL EAIENRIKET ITALPDEDTL KAPTLEEPKL 300
IGNLFKDLTK KLMRAQIIED GVRVDGRQLD EVRPISCRVG VLPRRVHGSG 350
LFNRGLTQVL SIATLGTPGD AQDLGDDLHP EDEKRYLHHY NFPPFSVGET 400
RPMRSPGRRE IGHGALAERA IVPVLPPQEE FPYVLRVVSE VLSSNGSTSM 450
GSVCGSTLAL MDAGVPLKKP VSGAAMGLIK EGEEVRILTD IQGIEDFLGD 500
MDFKVAGTDS GITALQMDMK IPGLSMEVVA KAIEQALPAR KHILEKMLAT 550
LEKPRTELSP HAPRLLTIKI DPDLIGLVIG PGGKTVKGIT EQTGTKIDID 600
DDGTVTISST DGEQAEKAKR LIYNMTRKLN EGEVYLGRVT RIIQIGAFVE 650
VLPGKEGMIH ISQLAEGRVG KVEDEVAVGD EVLVKVREID SKGRLNLTRL 700
GIHPDEAAAA RKAATVV 717
Length:717
Mass (Da):78,010
Last modified:March 18, 2008 - v1
Checksum:iA889548D74795D26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009552 Genomic DNA. Translation: BAG05161.1.
RefSeqiWP_012267692.1. NC_010296.1.
YP_001660353.1. NC_010296.1.

Genome annotation databases

EnsemblBacteriaiBAG05161; BAG05161; MAE_53390.
GeneIDi5866178.
KEGGimar:MAE_53390.
PATRICi22635127. VBIMicAer59304_4866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009552 Genomic DNA. Translation: BAG05161.1 .
RefSeqi WP_012267692.1. NC_010296.1.
YP_001660353.1. NC_010296.1.

3D structure databases

ProteinModelPortali B0JYC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 449447.MAE_53390.

Proteomic databases

PaxDbi B0JYC3.
PRIDEi B0JYC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG05161 ; BAG05161 ; MAE_53390 .
GeneIDi 5866178.
KEGGi mar:MAE_53390.
PATRICi 22635127. VBIMicAer59304_4866.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci MAER449447:GHO8-5382-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIES-843.

Entry informationi

Entry nameiPNP_MICAN
AccessioniPrimary (citable) accession number: B0JYC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 18, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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