B0JVE7 (G6PI_MICAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	MAE_16590

Organism

Microcystis aeruginosa (strain NIES-843) [Complete proteome] [HAMAP]

Taxonomic identifier

449447 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Microcystis

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000081242
Sites
	Active site	318	1	Proton donor By similarity
	Active site	347	1	By similarity
	Active site	451	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0JVE7 [UniParc]. Last modified March 18, 2008. Version 1. Checksum: 1C138E97C420688D	FASTA	524	58,113
	10 20 30 40 50 60 MDNLQLWQRY QDWLYYHPNL ELYLDVSRIP FDEAFLKGLE AKFERAFQDM AALEQGAIAN 70 80 90 100 110 120 PDEQRMVGHY WLRAPELAPN QELRDEITEP IAQIKEFVKK IHSGAIKPPN RAKFSHILCV 130 140 150 160 170 180 GIGGSALGPQ FVAEALSPLN PPLEIAFIDN TDPKGIDRTL AHLPLATTLV IVTSKSGGTP 190 200 210 220 230 240 EARNGMLEVR NAYEKLDLDF PQHAVAVTMP GSQLDKYAQD WLTRFPMQDW VGGRTSELSA 250 260 270 280 290 300 VGLLPAALQG IDIDEMLAGA KEMDMATRVH NLKKNPSALL ALAWYHEGKG KGEKDMVILP 310 320 330 340 350 360 YKDSLYLFSR YLQQLVMESL GKEKDLDGNK VYQGIAVYGN KGSTDQHAYV QQLREGVPNF 370 380 390 400 410 420 FATFIEVLKD RQGDSIEVET GSTAGDFLSG LLQGTRQALY ENSRHSITIT IPEVTPRQVG 430 440 450 460 470 480 ALIALYERAV SFYASLVNIN AYHQPGVEAG KKAAASILDL QRKIVQVVRE TGTSLDLATL 490 500 510 520 AAKIGASDQV EAIYKIVRHL NANRRSLTIT GDLSKPETLQ ISTR

References

[1]

"Complete genomic structure of the bloom-forming toxic cyanobacterium Microcystis aeruginosa NIES-843." Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M., Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A., Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M. , Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M. DNA Res. 14:247-256(2007) [PubMed: 18192279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NIES-843.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009552 Genomic DNA. Translation: BAG01481.1.
RefSeq	YP_001656673.1. NC_010296.1.
3D structure databases
ProteinModelPortal	B0JVE7.
ModBase	Search...
Protein-protein interaction databases
STRING	B0JVE7.
Proteomic databases
PRIDE	B0JVE7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5862459.
GenomeReviews	Gene locus MAE_16590 in contig AP009552_GR.
KEGG	mar:MAE_16590.
PATRIC	22628371. VBIMicAer59304_1523.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285902.
OMA	RTSITSA.
PhylomeDB	B0JVE7.
ProtClustDB	PRK14096.
Enzyme and pathway databases
BioCyc	MAER449447:MAE_16590-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. False negative. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_MICAN

Accession

Primary (citable) accession number: B0JVE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 18, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program