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B0JRN7 (HEMH_MICAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:MAE_09650
OrganismMicrocystis aeruginosa (strain NIES-843) [Complete proteome] [HAMAP]
Taxonomic identifier449447 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Microcystis

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Ferrochelatase HAMAP MF_00323
PRO_1000079197

Sites

Metal binding1961Iron By similarity
Metal binding2771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B0JRN7 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: 83CDA0438F24BAA5

FASTA38744,533
        10         20         30         40         50         60 
MGRVGVLLLN LGGPERLEDV RPFLFNLFSD PEIIRLPIKG LQKPLAWLIS TLRASKSQEN 

        70         80         90        100        110        120 
YRQIGGGSPL LKITEAQATA LQQRLKEMGR EVSVYIGMRY WNPFTEEAIE RIKRDHIKKL 

       130        140        150        160        170        180 
VILPLYPQFS ISTSGSSFRV LEEMWQQDPY LRLTEYTLIP SWYDHPTYLS AMADLIAREL 

       190        200        210        220        230        240 
EQCPNPDQVH IFFSAHGVPQ SYVEEAGDPY QRQIEECTRA IMRTLNRPNQ YTLAYQSRVG 

       250        260        270        280        290        300 
PVEWLKPYTE DALKELGEQG IKHLLVVPIS FVSEHIETLQ EIDIEYREVA EEAGIEHFQR 

       310        320        330        340        350        360 
VPALNTHPMF IESLSQLVVK SLEEKPTTFE QITHPKANMK MYPQERWEWG MTTAAEVWNG 

       370        380 
RLAMIGFLAI IIELITGQGP LHFVGLL

« Hide

References

[1]"Complete genomic structure of the bloom-forming toxic cyanobacterium Microcystis aeruginosa NIES-843."
Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M., Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A., Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M. expand/collapse author list , Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M.
DNA Res. 14:247-256(2007) [PubMed: 18192279] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NIES-843.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009552 Genomic DNA. Translation: BAG00787.1.
RefSeqYP_001655979.1. NC_010296.1.

3D structure databases

ProteinModelPortalB0JRN7.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0JRN7.

Proteomic databases

PRIDEB0JRN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5861763.
GenomeReviewsGene locus MAE_09650 in contig AP009552_GR.
KEGGmar:MAE_09650.
PATRIC22627093. VBIMicAer59304_0886.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBB0JRN7.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycMAER449447:MAE_09650-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR022796. Chloroa_b-bind.
IPR023329. Chlorophyll_a/b-bd_dom.
IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
Gene3DG3DSA:1.10.3460.10. G3DSA:1.10.3460.10. 1 hit.
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00504. Chloroa_b-bind. 1 hit.
PF00762. Ferrochelatase. 1 hit.
[Graphical view]
SUPFAMSSF103511. SSF103511. 1 hit.
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_MICAN
AccessionPrimary (citable) accession number: B0JRN7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 18, 2008
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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