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Protein

Glutaminase

Gene

glsA

Organism
Microcystis aeruginosa (strain NIES-843)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801SubstrateUniRule annotation
Binding sitei130 – 1301SubstrateUniRule annotation
Binding sitei174 – 1741SubstrateUniRule annotation
Binding sitei181 – 1811SubstrateUniRule annotation
Binding sitei205 – 2051SubstrateUniRule annotation
Binding sitei257 – 2571SubstrateUniRule annotation
Binding sitei275 – 2751Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMAER449447:GHO8-3804-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:MAE_37760
OrganismiMicrocystis aeruginosa (strain NIES-843)
Taxonomic identifieri449447 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesMicrocystis
ProteomesiUP000001510 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338GlutaminasePRO_0000336031Add
BLAST

Proteomic databases

PaxDbiB0JPM4.
PRIDEiB0JPM4.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi449447.MAE_37760.

Structurei

3D structure databases

ProteinModelPortaliB0JPM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiISKAFVF.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

B0JPM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPKDFISP VNSGQKLVYP FRNYLNYLHD KYSDLQTGKI ADYIPELALA
60 70 80 90 100
APQWFGISVI TTDGQIFEVG DCQQTFTVQS ISKAFVFGLA LEDHGREYVN
110 120 130 140 150
SKVGVEPTGE AFNSIILDEK TNRPYNPMVN AGAIATTDLI TGQNATERLK
160 170 180 190 200
RILEMFKRYT GRDHEINVPV FLSEKSTGNR NRAMAYLMLN FGMVSDKIEE
210 220 230 240 250
TLDLYCQQCA ILVHAHDLAL MAATLANGGV NPITGIRAID EHYVQDVISV
260 270 280 290 300
MLTCGMYDAS GEWAYRVGLP AKSGVGGGIT AVVPHQLGIG TFSPLLDEKG
310 320 330
NSIRGVKICQ NISEDFGLHL FNVAKPERDL KTWLEGNS
Length:338
Mass (Da):37,192
Last modified:March 17, 2008 - v1
Checksum:i4D83355EA9F0A2D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009552 Genomic DNA. Translation: BAG03598.1.
RefSeqiYP_001658790.1. NC_010296.1.

Genome annotation databases

EnsemblBacteriaiBAG03598; BAG03598; MAE_37760.
KEGGimar:MAE_37760.
PATRICi22632201. VBIMicAer59304_3417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009552 Genomic DNA. Translation: BAG03598.1.
RefSeqiYP_001658790.1. NC_010296.1.

3D structure databases

ProteinModelPortaliB0JPM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi449447.MAE_37760.

Proteomic databases

PaxDbiB0JPM4.
PRIDEiB0JPM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG03598; BAG03598; MAE_37760.
KEGGimar:MAE_37760.
PATRICi22632201. VBIMicAer59304_3417.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiISKAFVF.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciMAER449447:GHO8-3804-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIES-843.

Entry informationi

Entry nameiGLSA_MICAN
AccessioniPrimary (citable) accession number: B0JPM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 19, 2008
Last sequence update: March 17, 2008
Last modified: March 31, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.