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B0JPI1 (B0JPI1_MICAN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF HAMAP MF_00333 EMBL BAG00492.1
Ordered Locus Names:MAE_06700
OrganismMicrocystis aeruginosa (strain NIES-843) [Complete proteome] [HAMAP]
Taxonomic identifier449447 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Microcystis

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 SAAS SAAS018375

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 SAAS SAAS018375

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 SAAS SAAS018375

Subunit structure

Homodimer By similarity. HAMAP MF_00333 SAAS SAAS018375

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region38 – 4710Important for dimerization By similarity HAMAP MF_00333
Region98 – 1003Substrate binding By similarity HAMAP MF_00333
Region251 – 28636Important for dimerization By similarity HAMAP MF_00333
Region269 – 2746Substrate binding By similarity HAMAP MF_00333

Sites

Active site961Proton donor By similarity HAMAP MF_00333
Binding site821Substrate By similarity HAMAP MF_00333
Site1601Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
B0JPI1 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: BA9B446EE5ABA5D6

FASTA31536,806
        10         20         30         40         50         60 
MKSLQDEICQ GLEEVDGQAK FIEDSWQRPE GGGGRSRVLR EGAIFEQAGV NFSEVWGKEL 

        70         80         90        100        110        120 
PPSIAKQRPE AAGHQFYATG TSMVLHPHNP YIPTVHLNYR YFEAGPVWWF GGGADLTPYY 

       130        140        150        160        170        180 
AFEEDASHFH RTFKQVCDQH HPEYYPVFKR WCDEYFYLNH RQEARGIGGI FFDYQDGLDP 

       190        200        210        220        230        240 
LYRGPFAESD AAIYSEKLSP QQPRNWEEIF SFINDCGRAF LPAYVPIVQK RRSTEYGDRE 

       250        260        270        280        290        300 
RQFQLYRRGR YVEFNLVYDR GTIFGLQTNG RTESILMSLP PLVRWEYCYQ PAPNTPEAKL 

       310 
YDVFLKPQDW VNWQG

« Hide

References

[1]"Complete genomic structure of the bloom-forming toxic cyanobacterium Microcystis aeruginosa NIES-843."
Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M., Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A., Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M. expand/collapse author list , Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M.
DNA Res. 14:247-256(2007) [PubMed: 18192279] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009552 Genomic DNA. Translation: BAG00492.1.
RefSeqYP_001655684.1. NC_010296.1.

3D structure databases

ProteinModelPortalB0JPI1.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0JPI1.

Proteomic databases

PRIDEB0JPI1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5861467.
GenomeReviewsGene locus MAE_06700 in contig AP009552_GR.
KEGGmar:MAE_06700.
PATRIC22626543. VBIMicAer59304_0612.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG631180.
OMAVKAYLLD.
PhylomeDBB0JPI1.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0JPI1_MICAN
AccessionPrimary (citable) accession number: B0JPI1
Entry history
Integrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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