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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Microcystis aeruginosa (strain NIES-843)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotationSAAS annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotation
Biological processPurine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotationSAAS annotation (EC:6.3.2.6UniRule annotationSAAS annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotationImported
Ordered Locus Names:MAE_31380Imported
OrganismiMicrocystis aeruginosa (strain NIES-843)Imported
Taxonomic identifieri449447 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesMicrocystaceaeMicrocystis
Proteomesi
  • UP000001510 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiB0JLD6.
PRIDEiB0JLD6.

Interactioni

Protein-protein interaction databases

STRINGi449447.MAE_31380.

Structurei

3D structure databases

ProteinModelPortaliB0JLD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 232SAICAR_syntInterPro annotationAdd BLAST230

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QPR. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.
OrthoDBiPOG091H02H7.

Family and domain databases

CDDicd01415. SAICAR_synt_PurC. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiView protein in InterPro
IPR028923. SAICAR_synt/ADE2_N.
IPR033934. SAICAR_synt_PurC.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
PfamiView protein in Pfam
PF01259. SAICAR_synt. 1 hit.
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiView protein in PROSITE
PS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B0JLD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLYEGKAK ILYQTDDPDI LLTYYKDDAT AFNAQKRGQI VGKGEINCTV
60 70 80 90 100
STALFQWLES LGIPTHYIDR PSSREMRVKA IKIIPLEVVV RNIAAGSLCK
110 120 130 140 150
QTGLKEGKVL PFPLVEFYLK DDALGDPLLT PDRIKVIDIA SEEQVNQLRD
160 170 180 190 200
LALQINQYLQ EFFDKCQIIL VDFKLEFGVD KTGKIYLGDE ISPDTCRLWD
210 220 230 240
KTQEDAQARI LDKDRFRRDL GDVETAYQQV QARVLQQIES L
Length:241
Mass (Da):27,562
Last modified:March 18, 2008 - v1
Checksum:iBA9DA872277297EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009552 Genomic DNA. Translation: BAG02960.1.

Genome annotation databases

EnsemblBacteriaiBAG02960; BAG02960; MAE_31380.
KEGGimar:MAE_31380.

Similar proteinsi

Entry informationi

Entry nameiB0JLD6_MICAN
AccessioniPrimary (citable) accession number: B0JLD6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 18, 2008
Last sequence update: March 18, 2008
Last modified: October 25, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported