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B0JL55

- PUR9_MICAN

UniProt

B0JL55 - PUR9_MICAN

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, MAE_62320
Organism
Microcystis aeruginosa (strain NIES-843)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciMAER449447:GHO8-6284-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:MAE_62320
OrganismiMicrocystis aeruginosa (strain NIES-843)
Taxonomic identifieri449447 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesMicrocystis
ProteomesiUP000001510: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000076485Add
BLAST

Proteomic databases

PaxDbiB0JL55.
PRIDEiB0JL55.

Interactioni

Protein-protein interaction databases

STRINGi449447.MAE_62320.

Structurei

3D structure databases

ProteinModelPortaliB0JL55.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B0JL55-1 [UniParc]FASTAAdd to Basket

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MGRLALISVT DKTGIVDFAR QLTEEFDFEI ISSGGTAKTL QSAGIPVIKV    50
GEYTGSPEIL GGRVKTLHPR IHGGILARRD WQSDLAEMEA NQIRPFDLVV 100
VNLYPFEQTI ANPDVTTAQA IEQIDIGGPA MLRASAKNFA HLTVISNPKY 150
YEQYLSQLRQ NNGEISLEFR QKMAGETFAL TNAYDGAIAA YFASLNGETT 200
RFNLAGNALQ TLRYGENPHQ SATWYGSGTM AQGWGKATLL QGKELSYNNL 250
VDLEAARRLI AEFGSEEPAA AILKHTNPCG VAIGGSLVEA YTKAFNADAI 300
SAFGGIVALN QAIDEATAKE LTKTFLECVV APDCSPEAQD ILAKKSKVRI 350
LLLPDLTTGE KQTVKVIAGG FLVQAADDVV ETPDEWRVVT EKQPTPAQLA 400
ELLFAWKVSK HVKSNAIVVT KNQTTLGVGA GQMNRVGSVK IALEQAAEAA 450
KGGYLASDGF FPFDDSVRTA AQFGIEAIVQ PGGSLKDQDS INAANELGLI 500
MVLTGIRHFL H 511
Length:511
Mass (Da):54,930
Last modified:March 18, 2008 - v1
Checksum:iBAED3E34D2F8B3D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009552 Genomic DNA. Translation: BAG06054.1.
RefSeqiYP_001661246.1. NC_010296.1.

Genome annotation databases

EnsemblBacteriaiBAG06054; BAG06054; MAE_62320.
GeneIDi5867080.
KEGGimar:MAE_62320.
PATRICi22636836. VBIMicAer59304_5712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009552 Genomic DNA. Translation: BAG06054.1 .
RefSeqi YP_001661246.1. NC_010296.1.

3D structure databases

ProteinModelPortali B0JL55.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 449447.MAE_62320.

Proteomic databases

PaxDbi B0JL55.
PRIDEi B0JL55.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG06054 ; BAG06054 ; MAE_62320 .
GeneIDi 5867080.
KEGGi mar:MAE_62320.
PATRICi 22636836. VBIMicAer59304_5712.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci MAER449447:GHO8-6284-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIES-843.

Entry informationi

Entry nameiPUR9_MICAN
AccessioniPrimary (citable) accession number: B0JL55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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