B0JL16 (CYSC_MICAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylyl-sulfate kinase
EC=2.7.1.25

Alternative name(s):
APS kinase
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase

Gene names

Name:	cysC
Ordered Locus Names:	MAE_31330

Organism

Microcystis aeruginosa (strain NIES-843) [Complete proteome] [HAMAP]

Taxonomic identifier

449447 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Microcystis

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate By similarity. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylylsulfate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_1000075086
Regions
	Nucleotide binding	12 – 19	8	ATP By similarity
Sites
	Active site	86	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0JL16 [UniParc]. Last modified March 18, 2008. Version 1. Checksum: F577C482D0D63DC2	FASTA	181	20,110
	10 20 30 40 50 60 MKQRGVTVWL TGLSGAGKST ITEALQAKLI AEGYSIEVLD GDIVRTNLTK GLGFSKEDRD 70 80 90 100 110 120 ENIRRIGFVS NLLTRHGVIV LVSAISPYRE IREEVRGKIG NFVEVFVNAP LSVCEDRDVK 130 140 150 160 170 180 GLYKRARAGE IKSFTGIDDP YEPPFNPEVE CRTDLETLEE SVAKVWNKLT ELGYIHQAVA V

References

[1]

"Complete genomic structure of the bloom-forming toxic cyanobacterium Microcystis aeruginosa NIES-843." Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M., Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A., Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M. , Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M. DNA Res. 14:247-256(2007) [PubMed: 18192279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NIES-843.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009552 Genomic DNA. Translation: BAG02955.1.
RefSeq	YP_001658147.1. NC_010296.1.
3D structure databases
ProteinModelPortal	B0JL16.
ModBase	Search...
Protein-protein interaction databases
STRING	B0JL16.
Proteomic databases
PRIDE	B0JL16.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5863950.
GenomeReviews	Gene locus MAE_31330 in contig AP009552_GR.
KEGG	mar:MAE_31330.
PATRIC	22631025. VBIMicAer59304_2835.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309946.
OMA	MAREIIG.
PhylomeDB	B0JL16.
ProtClustDB	PRK00889.
Enzyme and pathway databases
BioCyc	MAER449447:MAE_31330-MONOMER.
Family and domain databases
HAMAP	MF_00065. Adenylyl_sulf_kinase. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
KO	K00860.
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00455. ApsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_MICAN

Accession

Primary (citable) accession number: B0JL16

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 18, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program