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Protein

Adaptive-response sensory-kinase SasA

Gene

sasA

Organism
Microcystis aeruginosa (strain NIES-843)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Biological rhythms, Two-component regulatory system

Enzyme and pathway databases

BioCyciMAER449447:GHO8-6131-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adaptive-response sensory-kinase SasAUniRule annotation (EC:2.7.-.-UniRule annotation)
Alternative name(s):
Synechococcus adaptive sensor protein AUniRule annotation
Gene namesi
Name:sasAUniRule annotation
Ordered Locus Names:MAE_60820
OrganismiMicrocystis aeruginosa (strain NIES-843)
Taxonomic identifieri449447 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesMicrocystis
Proteomesi
  • UP000001510 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Adaptive-response sensory-kinase SasAPRO_1000088440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651Phosphohistidine; by autocatalysisUniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB0JK50.
PRIDEiB0JK50.

Interactioni

Subunit structurei

Interacts with KaiC. Participates in the KaiABC complex, whose core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers.UniRule annotation

Protein-protein interaction databases

STRINGi449447.MAE_60820.

Structurei

3D structure databases

ProteinModelPortaliB0JK50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini162 – 384223Histidine kinaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JA5. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000233315.
KOiK08479.
OMAiAHYGQIW.
OrthoDBiPOG091H0M9D.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
3.40.30.10. 1 hit.
HAMAPiMF_01837. Kinase_SasA. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR011649. KaiB_domain.
IPR023527. Kinase_SasA.
IPR004358. Sig_transdc_His_kin-like_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF07689. KaiB. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM01248. KaiB. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0JK50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSNEPLTA LGRETTTPLS IQLLLFVDDR PSSQEIIRQI QSYLQSLKSD
60 70 80 90 100
YPIDLQIIEI RQQPHLVEHF RLVATPALVK IAPGPRHTLA GSNLVEQFKK
110 120 130 140 150
WLVRWQKAIK EEVKNHHAED AQLQEVEHSG ELIRIADEVF RLKQEKEELL
160 170 180 190 200
EQLKFKDQIL AMLAHDLRSP LTAASIAVET LELAYHQPDT ERSLQLREQL
210 220 230 240 250
HQQARKQFRI MNRLITDILQ ASKSMAAQFT LHQSKFYLQS LCQEILSQFT
260 270 280 290 300
DTFQEKTLIF QSDIPQDLPP VYADEELIRQ VIINLLENGI KYTPAGGEIT
310 320 330 340 350
LSVLHRTTQK VQVSISDTGP GIPEEKQEHI FEGHVRLKRD EGKEGYGIGL
360 370 380
SVCRKIIRAH YGQIWVDSVP DHGSSFHFTL PVYR
Length:384
Mass (Da):44,103
Last modified:March 18, 2008 - v1
Checksum:iD54D459FEE9EDDD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009552 Genomic DNA. Translation: BAG05904.1.
RefSeqiWP_012268234.1. NC_010296.1.

Genome annotation databases

EnsemblBacteriaiBAG05904; BAG05904; MAE_60820.
GeneIDi5866927.
KEGGimar:MAE_60820.
PATRICi22636541. VBIMicAer59304_5568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009552 Genomic DNA. Translation: BAG05904.1.
RefSeqiWP_012268234.1. NC_010296.1.

3D structure databases

ProteinModelPortaliB0JK50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi449447.MAE_60820.

Proteomic databases

PaxDbiB0JK50.
PRIDEiB0JK50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG05904; BAG05904; MAE_60820.
GeneIDi5866927.
KEGGimar:MAE_60820.
PATRICi22636541. VBIMicAer59304_5568.

Phylogenomic databases

eggNOGiENOG4108JA5. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000233315.
KOiK08479.
OMAiAHYGQIW.
OrthoDBiPOG091H0M9D.

Enzyme and pathway databases

BioCyciMAER449447:GHO8-6131-MONOMER.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
3.40.30.10. 1 hit.
HAMAPiMF_01837. Kinase_SasA. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR011649. KaiB_domain.
IPR023527. Kinase_SasA.
IPR004358. Sig_transdc_His_kin-like_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF07689. KaiB. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM01248. KaiB. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSASA_MICAN
AccessioniPrimary (citable) accession number: B0JK50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 18, 2008
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.