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B0I1T2

- MYO1G_HUMAN

UniProt

B0I1T2 - MYO1G_HUMAN

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Protein

Unconventional myosin-Ig

Gene

MYO1G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.By similarity
Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.1 PublicationCurated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Adaptive immunity, Immunity

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Lipid-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ig
Cleaved into the following chain:
Minor histocompatibility antigen HA-21 Publication
Short name:
mHag HA-2
Gene namesi
Name:MYO1G
Synonyms:HA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:13880. MYO1G.

Subcellular locationi

Cell membrane 2 Publications; Peripheral membrane protein 2 Publications. Cell projectionphagocytic cup By similarity
Note: Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup. In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed (By similarity). Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May be enriched in peripheral processes, such as microvilli or ruffles.By similarity1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. membrane Source: UniProtKB
  3. myosin complex Source: UniProtKB-KW
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi815 – 8151K → A: Reduced membrane association. 1 Publication
Mutagenesisi826 – 8261R → A: Reduced membrane association. 1 Publication
Mutagenesisi876 – 8761R → A: No effect on membrane localization. 1 Publication
Mutagenesisi880 – 8801R → A: No effect on membrane localization. 1 Publication
Mutagenesisi883 – 8831K → A: No effect on membrane localization; when associated with R-885.
Mutagenesisi885 – 8851R → A: No effect on membrane localization; when associated with K-883. 1 Publication
Mutagenesisi898 – 8981K → A: Reduced membrane association. 1 Publication
Mutagenesisi903 – 9031R → A: No effect on membrane localization; when associated with R-906. 1 Publication
Mutagenesisi906 – 9061R → A: No effect on membrane localization; when associated with R-903. 1 Publication
Mutagenesisi909 – 9091R → A: No effect on membrane localization. 1 Publication
Mutagenesisi934 – 9341R → A: No effect on membrane localization. 1 Publication
Mutagenesisi945 – 9451R → A: No effect on membrane localization. 1 Publication
Mutagenesisi947 – 9471R → A: No effect on membrane localization. 1 Publication
Mutagenesisi953 – 9531R → A: No effect on membrane localization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10181018Unconventional myosin-IgPRO_0000340316Add
BLAST
Peptidei41 – 499Minor histocompatibility antigen HA-21 PublicationPRO_0000340317

Proteomic databases

MaxQBiB0I1T2.
PaxDbiB0I1T2.
PRIDEiB0I1T2.

PTM databases

PhosphoSiteiB0I1T2.

Expressioni

Tissue specificityi

Specifically expressed in hematopoietic cells.2 Publications

Gene expression databases

BgeeiB0I1T2.
CleanExiHS_MYO1G.
ExpressionAtlasiB0I1T2. baseline and differential.
GenevestigatoriB0I1T2.

Organism-specific databases

HPAiHPA021252.

Interactioni

Subunit structurei

Interacts with calmodulin; via its IQ motifs.By similarity

Protein-protein interaction databases

BioGridi122031. 6 interactions.
IntActiB0I1T2. 4 interactions.
MINTiMINT-7307233.
STRINGi9606.ENSP00000258787.

Structurei

3D structure databases

ProteinModelPortaliB0I1T2.
SMRiB0I1T2. Positions 10-734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 707699Myosin motorAdd
BLAST
Domaini710 – 73930IQAdd
BLAST
Domaini814 – 1016203Myosin tailSequence AnalysisAdd
BLAST

Domaini

The myosin tail domain mediates binding to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) and binds to membranous compartments. It is required for recruitment to Fc-gamma receptor (Fc-gamma-R) phagocytic cups.By similarity

Sequence similaritiesi

Contains 1 IQ domain.Curated
Contains 1 myosin motor domain.Curated
Contains 1 myosin tail domain.Curated

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118956.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiB0I1T2.
KOiK10356.
OMAiEQHGLQG.
OrthoDBiEOG7V49XQ.
PhylomeDBiB0I1T2.
TreeFamiTF312960.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B0I1T2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDEEGPEYG KPDFVLLDQV TMEDFMRNLQ LRFEKGRIYT YIGEVLVSVN
60 70 80 90 100
PYQELPLYGP EAIARYQGRE LYERPPHLYA VANAAYKAMK HRSRDTCIVI
110 120 130 140 150
SGESGAGKTE ASKHIMQYIA AVTNPSQRAE VERVKDVLLK STCVLEAFGN
160 170 180 190 200
ARTNRNHNSS RFGKYMDINF DFKGDPIGGH IHSYLLEKSR VLKQHVGERN
210 220 230 240 250
FHAFYQLLRG SEDKQLHELH LERNPAVYNF THQGAGLNMT VHSALDSDEQ
260 270 280 290 300
SHQAVTEAMR VIGFSPEEVE SVHRILAAIL HLGNIEFVET EEGGLQKEGL
310 320 330 340 350
AVAEEALVDH VAELTATPRD LVLRSLLART VASGGRELIE KGHTAAEASY
360 370 380 390 400
ARDACAKAVY QRLFEWVVNR INSVMEPRGR DPRRDGKDTV IGVLDIYGFE
410 420 430 440 450
VFPVNSFEQF CINYCNEKLQ QLFIQLILKQ EQEEYEREGI TWQSVEYFNN
460 470 480 490 500
ATIVDLVERP HRGILAVLDE ACSSAGTITD RIFLQTLDMH HRHHLHYTSR
510 520 530 540 550
QLCPTDKTME FGRDFRIKHY AGDVTYSVEG FIDKNRDFLF QDFKRLLYNS
560 570 580 590 600
TDPTLRAMWP DGQQDITEVT KRPLTAGTLF KNSMVALVEN LASKEPFYVR
610 620 630 640 650
CIKPNEDKVA GKLDENHCRH QVAYLGLLEN VRVRRAGFAS RQPYSRFLLR
660 670 680 690 700
YKMTCEYTWP NHLLGSDKAA VSALLEQHGL QGDVAFGHSK LFIRSPRTLV
710 720 730 740 750
TLEQSRARLI PIIVLLLQKA WRGTLARWRC RRLRAIYTIM RWFRRHKVRA
760 770 780 790 800
HLAELQRRFQ AARQPPLYGR DLVWPLPPAV LQPFQDTCHA LFCRWRARQL
810 820 830 840 850
VKNIPPSDMP QIKAKVAAMG ALQGLRQDWG CRRAWARDYL SSATDNPTAS
860 870 880 890 900
SLFAQRLKTL QDKDGFGAVL FSSHVRKVNR FHKIRNRALL LTDQHLYKLD
910 920 930 940 950
PDRQYRVMRA VPLEAVTGLS VTSGGDQLVV LHARGQDDLV VCLHRSRPPL
960 970 980 990 1000
DNRVGELVGV LAAHCQGEGR TLEVRVSDCI PLSHRGVRRL ISVEPRPEQP
1010
EPDFRCARGS FTLLWPSR
Length:1,018
Mass (Da):116,442
Last modified:January 11, 2011 - v2
Checksum:i3EB4ACC3D99A86E9
GO
Isoform 2 (identifier: B0I1T2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-230: LLRGSEDKQLHELHLERNPAVYNF → VSPEGKGRWKNGVGKGRAASWTSL
     231-1018: Missing.

Note: No experimental confirmation available.

Show »
Length:230
Mass (Da):26,151
Checksum:i7A80030FE7FCCE28
GO
Isoform 3 (identifier: B0I1T2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     526-1018: Missing.

Note: No experimental confirmation available.

Show »
Length:525
Mass (Da):59,815
Checksum:i1B25EB82195E4993
GO
Isoform 4 (identifier: B0I1T2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     652-722: KMTCEYTWPN...IVLLLQKAWR → WHLTPITPWA...TGGNMGMRAV
     723-1018: Missing.

Note: No experimental confirmation available.

Show »
Length:722
Mass (Da):82,279
Checksum:i6275117D9D1751C1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691N → K in BAB84961. 1 PublicationCurated
Sequence conflicti377 – 3771P → L in AAK58092. (PubMed:11544309)Curated
Sequence conflicti377 – 3771P → L in AAK58093. (PubMed:11544309)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491V → M in allele HA-2M; the HA-2V allele constitute the HA-2 epitope while HA-2M is not recognized by HA-2 cytotoxic T lymphocytes. 1 Publication
Corresponds to variant rs61739531 [ dbSNP | Ensembl ].
VAR_044013
Natural varianti489 – 4891M → T.3 Publications
Corresponds to variant rs3735485 [ dbSNP | Ensembl ].
VAR_044014
Natural varianti798 – 7981R → Q.
Corresponds to variant rs2107737 [ dbSNP | Ensembl ].
VAR_050212
Natural varianti861 – 8611Q → R.2 Publications
Corresponds to variant rs7792760 [ dbSNP | Ensembl ].
VAR_044015

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei207 – 23024LLRGS…AVYNF → VSPEGKGRWKNGVGKGRAAS WTSL in isoform 2. 1 PublicationVSP_034208Add
BLAST
Alternative sequencei231 – 1018788Missing in isoform 2. 1 PublicationVSP_034209Add
BLAST
Alternative sequencei526 – 1018493Missing in isoform 3. 1 PublicationVSP_034210Add
BLAST
Alternative sequencei652 – 72271KMTCE…QKAWR → WHLTPITPWAIVPVWSPRGR SRGSPNSTSQTSIQAGTSTL LASRHQNIWEDMCVSTCMWG HTGGNMGMRAV in isoform 4. 1 PublicationVSP_034211Add
BLAST
Alternative sequencei723 – 1018296Missing in isoform 4. 1 PublicationVSP_034212Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074050 mRNA. Translation: BAB84876.1. Sequence problems.
AK074135 mRNA. Translation: BAB84961.1.
AB290179 mRNA. Translation: BAG06733.1.
AC004847 Genomic DNA. No translation available.
AF380932 mRNA. Translation: AAK58092.1.
AF380933 mRNA. Translation: AAK58093.1.
BC015693 mRNA. Translation: AAH15693.2.
CCDSiCCDS34629.1. [B0I1T2-1]
RefSeqiNP_149043.2. NM_033054.2. [B0I1T2-1]
UniGeneiHs.37617.

Genome annotation databases

EnsembliENST00000258787; ENSP00000258787; ENSG00000136286. [B0I1T2-1]
GeneIDi64005.
KEGGihsa:64005.
UCSCiuc003tmg.2. human. [B0I1T2-1]
uc003tmi.1. human. [B0I1T2-4]
uc003tmj.2. human. [B0I1T2-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074050 mRNA. Translation: BAB84876.1 . Sequence problems.
AK074135 mRNA. Translation: BAB84961.1 .
AB290179 mRNA. Translation: BAG06733.1 .
AC004847 Genomic DNA. No translation available.
AF380932 mRNA. Translation: AAK58092.1 .
AF380933 mRNA. Translation: AAK58093.1 .
BC015693 mRNA. Translation: AAH15693.2 .
CCDSi CCDS34629.1. [B0I1T2-1 ]
RefSeqi NP_149043.2. NM_033054.2. [B0I1T2-1 ]
UniGenei Hs.37617.

3D structure databases

ProteinModelPortali B0I1T2.
SMRi B0I1T2. Positions 10-734.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122031. 6 interactions.
IntActi B0I1T2. 4 interactions.
MINTi MINT-7307233.
STRINGi 9606.ENSP00000258787.

PTM databases

PhosphoSitei B0I1T2.

Proteomic databases

MaxQBi B0I1T2.
PaxDbi B0I1T2.
PRIDEi B0I1T2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258787 ; ENSP00000258787 ; ENSG00000136286 . [B0I1T2-1 ]
GeneIDi 64005.
KEGGi hsa:64005.
UCSCi uc003tmg.2. human. [B0I1T2-1 ]
uc003tmi.1. human. [B0I1T2-4 ]
uc003tmj.2. human. [B0I1T2-3 ]

Organism-specific databases

CTDi 64005.
GeneCardsi GC07M045003.
H-InvDB HIX0006659.
HGNCi HGNC:13880. MYO1G.
HPAi HPA021252.
MIMi 600642. gene.
neXtProti NX_B0I1T2.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5022.
GeneTreei ENSGT00760000118956.
HOGENOMi HOG000260264.
HOVERGENi HBG062373.
InParanoidi B0I1T2.
KOi K10356.
OMAi EQHGLQG.
OrthoDBi EOG7V49XQ.
PhylomeDBi B0I1T2.
TreeFami TF312960.

Miscellaneous databases

GenomeRNAii 64005.
NextBioi 65808.
PROi B0I1T2.
SOURCEi Search...

Gene expression databases

Bgeei B0I1T2.
CleanExi HS_MYO1G.
ExpressionAtlasi B0I1T2. baseline and differential.
Genevestigatori B0I1T2.

Family and domain databases

InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 193-1018 (ISOFORM 3), VARIANT THR-489.
    Tissue: Spleen.
  2. "Multiplex amplification and cloning of 5'-ends of cDNA by ligase-free recombination: preparation of full-length cDNA clones encoding motor proteins."
    Yamakawa H., Kikuno R.F., Nagase T., Ohara O.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-489 AND ARG-861.
    Tissue: Spleen.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The HA-2 minor histocompatibility antigen is derived from a diallelic gene encoding a novel human class I myosin protein."
    Pierce R.A., Field E.D., Mutis T., Golovina T.N., Von Kap-Herr C., Wilke M., Pool J., Shabanowitz J., Pettenati M.J., Eisenlohr L.C., Hunt D.F., Goulmy E., Engelhard V.H.
    J. Immunol. 167:3223-3230(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-665 (ISOFORM 4), IDENTIFICATION AS THE MINOR HISTOCOMPATIBILITY ANTIGEN HA-2, VARIANTS HA-2M MET-49 AND THR-489, CHARACTERIZATION OF VARIANT HA-2M MET-49, TISSUE SPECIFICITY.
  5. "Identification of a graft versus host disease-associated human minor histocompatibility antigen."
    den Haan J.M.M., Sherman N.E., Blokland E., Huczko E., Koning F., Drijfhout J.W., Skipper J., Shabanowitz J., Hunt D.F., Engelhard V.H., Goulmy E.
    Science 268:1476-1480(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 41-49 (ISOFORM 1).
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 723-1018 (ISOFORM 1), VARIANT ARG-861.
    Tissue: B-cell.
  7. "Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity."
    Olety B., Walte M., Honnert U., Schillers H., Bahler M.
    FEBS Lett. 584:493-499(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH)."
    Patino-Lopez G., Aravind L., Dong X., Kruhlak M.J., Ostap E.M., Shaw S.
    J. Biol. Chem. 285:8675-8686(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-815; ARG-826; ARG-876; ARG-880; ARG-885; LYS-898; ARG-903; ARG-906; ARG-909; ARG-934; ARG-945; ARG-947 AND ARG-953.

Entry informationi

Entry nameiMYO1G_HUMAN
AccessioniPrimary (citable) accession number: B0I1T2
Secondary accession number(s): Q8TEI9
, Q8TES2, Q96BE2, Q96RI5, Q96RI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3