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B0G172 (PGTB2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable geranylgeranyl transferase type-2 subunit beta

EC=2.5.1.60
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name=GGTase-II-beta
Rab geranyl-geranyltransferase subunit beta
Short name=Rab GG transferase beta
Short name=Rab GGTase beta
Rab geranylgeranyltransferase subunit beta
Type II protein geranyl-geranyltransferase subunit beta
Gene names
Name:rabggtb
ORF Names:DDB_G0290671
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal By similarity.

Catalytic activity

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Heterodimer of an alpha and a beta subunit By similarity.

Sequence similarities

Belongs to the protein prenyltransferase subunit beta family.

Contains 6 PFTB repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Probable geranylgeranyl transferase type-2 subunit beta
PRO_0000331291

Regions

Repeat24 – 6542PFTB 1
Repeat72 – 11342PFTB 2
Repeat120 – 16142PFTB 3
Repeat168 – 20942PFTB 4
Repeat216 – 25742PFTB 5
Repeat264 – 30643PFTB 6
Region194 – 1963Geranylgeranyl diphosphate binding By similarity
Region236 – 24813Geranylgeranyl diphosphate binding By similarity
Compositional bias10 – 156Poly-Thr

Sites

Metal binding2421Zinc By similarity
Metal binding2421Zinc; catalytic By similarity
Metal binding2441Zinc By similarity
Metal binding2441Zinc; catalytic By similarity
Metal binding2941Zinc By similarity
Metal binding2941Zinc; via tele nitrogen; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
B0G172 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: C5741A1FB950F662

FASTA33938,012
        10         20         30         40         50         60 
MTDNINKEST TTTTTIDHTT NLLIDKHVEY IVKLGSKKDS FEYWVTEHIR MNGMYWGLSS 

        70         80         90        100        110        120 
LYLLKSLDKL DKNEVIQWLL SCQKSNGGFG GNTSHDDHLL STLSAVQILI QYDALDKIDI 

       130        140        150        160        170        180 
NSVVDYVVKL QREDGSFVGD QWGEVDTRFS YAAIMCLSLL KSLDKINCEK AVEYILSCQN 

       190        200        210        220        230        240 
FDGGFGSIPG AESHAGQIFT CVGALSILNE INKIDIDKLG WWLSERQLPN GGLNGRPEKS 

       250        260        270        280        290        300 
SDVCYSWWVL SALSAIDRLH WIDNDKLKSY ILKCQDNETG GIADKPGDIP DVFHTFFGIC 

       310        320        330 
GLSLMGYFKD QIESIDPVYA LGTKTLQKLG LNLPWNKNL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000164 Genomic DNA. Translation: EDR41036.1.
RefSeqXP_001733035.1. XM_001732983.1.

3D structure databases

ProteinModelPortalB0G172.
SMRB0G172. Positions 18-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0219584.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0233949; DDB0233949; DDB_G0290671.
GeneID8627741.
KEGGddi:DDB_G0290671.

Organism-specific databases

dictyBaseDDB_G0290671. rabggtb.

Phylogenomic databases

eggNOGCOG5029.
OMAESHAGLI.
PhylomeDBB0G172.

Family and domain databases

Gene3D1.50.10.20. 1 hit.
InterProIPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERPTHR11774:SF9. PTHR11774:SF9. 1 hit.
PfamPF00432. Prenyltrans. 2 hits.
[Graphical view]
SUPFAMSSF48239. SSF48239. 1 hit.
ProtoNetSearch...

Other

PROB0G172.

Entry information

Entry namePGTB2_DICDI
AccessionPrimary (citable) accession number: B0G172
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 18, 2008
Last modified: July 9, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase