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Protein

Probable geranylgeranyl transferase type-2 subunit beta

Gene

rabggtb

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal.By similarity

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi242ZincBy similarity1
Metal bindingi242Zinc; catalyticBy similarity1
Metal bindingi244ZincBy similarity1
Metal bindingi244Zinc; catalyticBy similarity1
Metal bindingi294ZincBy similarity1
Metal bindingi294Zinc; via tele nitrogen; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DDI-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable geranylgeranyl transferase type-2 subunit beta (EC:2.5.1.60)
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name:
GGTase-II-beta
Rab geranyl-geranyltransferase subunit beta
Short name:
Rab GG transferase beta
Short name:
Rab GGTase beta
Rab geranylgeranyltransferase subunit beta
Type II protein geranyl-geranyltransferase subunit beta
Gene namesi
Name:rabggtb
ORF Names:DDB_G0290671
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290671. rabggtb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312911 – 339Probable geranylgeranyl transferase type-2 subunit betaAdd BLAST339

Proteomic databases

PaxDbiB0G172.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0233949.

Structurei

3D structure databases

ProteinModelPortaliB0G172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 65PFTB 1Add BLAST42
Repeati72 – 113PFTB 2Add BLAST42
Repeati120 – 161PFTB 3Add BLAST42
Repeati168 – 209PFTB 4Add BLAST42
Repeati216 – 257PFTB 5Add BLAST42
Repeati264 – 306PFTB 6Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 196Geranylgeranyl diphosphate bindingBy similarity3
Regioni236 – 248Geranylgeranyl diphosphate bindingBy similarityAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 15Poly-Thr6

Sequence similaritiesi

Contains 6 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0366. Eukaryota.
COG5029. LUCA.
InParanoidiB0G172.
KOiK05956.
OMAiVKRCQCP.
PhylomeDBiB0G172.

Family and domain databases

CDDicd02894. GGTase-II. 1 hit.
Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. PFTB_repeat.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF11. PTHR11774:SF11. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

B0G172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNINKEST TTTTTIDHTT NLLIDKHVEY IVKLGSKKDS FEYWVTEHIR
60 70 80 90 100
MNGMYWGLSS LYLLKSLDKL DKNEVIQWLL SCQKSNGGFG GNTSHDDHLL
110 120 130 140 150
STLSAVQILI QYDALDKIDI NSVVDYVVKL QREDGSFVGD QWGEVDTRFS
160 170 180 190 200
YAAIMCLSLL KSLDKINCEK AVEYILSCQN FDGGFGSIPG AESHAGQIFT
210 220 230 240 250
CVGALSILNE INKIDIDKLG WWLSERQLPN GGLNGRPEKS SDVCYSWWVL
260 270 280 290 300
SALSAIDRLH WIDNDKLKSY ILKCQDNETG GIADKPGDIP DVFHTFFGIC
310 320 330
GLSLMGYFKD QIESIDPVYA LGTKTLQKLG LNLPWNKNL
Length:339
Mass (Da):38,012
Last modified:March 18, 2008 - v1
Checksum:iC5741A1FB950F662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000164 Genomic DNA. Translation: EDR41036.1.
RefSeqiXP_001733035.1. XM_001732983.1.

Genome annotation databases

EnsemblProtistsiEDR41036; EDR41036; DDB_G0290671.
GeneIDi8627741.
KEGGiddi:DDB_G0290671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000164 Genomic DNA. Translation: EDR41036.1.
RefSeqiXP_001733035.1. XM_001732983.1.

3D structure databases

ProteinModelPortaliB0G172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0233949.

Proteomic databases

PaxDbiB0G172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEDR41036; EDR41036; DDB_G0290671.
GeneIDi8627741.
KEGGiddi:DDB_G0290671.

Organism-specific databases

dictyBaseiDDB_G0290671. rabggtb.

Phylogenomic databases

eggNOGiKOG0366. Eukaryota.
COG5029. LUCA.
InParanoidiB0G172.
KOiK05956.
OMAiVKRCQCP.
PhylomeDBiB0G172.

Enzyme and pathway databases

ReactomeiR-DDI-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.

Miscellaneous databases

PROiB0G172.

Family and domain databases

CDDicd02894. GGTase-II. 1 hit.
Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. PFTB_repeat.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF11. PTHR11774:SF11. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGTB2_DICDI
AccessioniPrimary (citable) accession number: B0G172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.