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B0G172

- PGTB2_DICDI

UniProt

B0G172 - PGTB2_DICDI

Protein

Probable geranylgeranyl transferase type-2 subunit beta

Gene

rabggtb

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal.By similarity

    Catalytic activityi

    Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi242 – 2421ZincBy similarity
    Metal bindingi242 – 2421Zinc; catalyticBy similarity
    Metal bindingi244 – 2441ZincBy similarity
    Metal bindingi244 – 2441Zinc; catalyticBy similarity
    Metal bindingi294 – 2941ZincBy similarity
    Metal bindingi294 – 2941Zinc; via tele nitrogen; catalyticBy similarity

    GO - Molecular functioni

    1. Rab geranylgeranyltransferase activity Source: UniProtKB
    2. Rab GTPase binding Source: UniProtKB
    3. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. protein geranylgeranylation Source: UniProtKB

    Keywords - Molecular functioni

    Prenyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable geranylgeranyl transferase type-2 subunit beta (EC:2.5.1.60)
    Alternative name(s):
    Geranylgeranyl transferase type II subunit beta
    Short name:
    GGTase-II-beta
    Rab geranyl-geranyltransferase subunit beta
    Short name:
    Rab GG transferase beta
    Short name:
    Rab GGTase beta
    Rab geranylgeranyltransferase subunit beta
    Type II protein geranyl-geranyltransferase subunit beta
    Gene namesi
    Name:rabggtb
    ORF Names:DDB_G0290671
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0290671. rabggtb.

    Subcellular locationi

    GO - Cellular componenti

    1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Probable geranylgeranyl transferase type-2 subunit betaPRO_0000331291Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0219584.

    Structurei

    3D structure databases

    ProteinModelPortaliB0G172.
    SMRiB0G172. Positions 18-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati24 – 6542PFTB 1Add
    BLAST
    Repeati72 – 11342PFTB 2Add
    BLAST
    Repeati120 – 16142PFTB 3Add
    BLAST
    Repeati168 – 20942PFTB 4Add
    BLAST
    Repeati216 – 25742PFTB 5Add
    BLAST
    Repeati264 – 30643PFTB 6Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni194 – 1963Geranylgeranyl diphosphate bindingBy similarity
    Regioni236 – 24813Geranylgeranyl diphosphate bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi10 – 156Poly-Thr

    Sequence similaritiesi

    Contains 6 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5029.
    KOiK05956.
    OMAiESHAGLI.
    PhylomeDBiB0G172.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    InterProiIPR001330. Prenyltrans.
    IPR026873. Ptb1.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PANTHERiPTHR11774:SF9. PTHR11774:SF9. 1 hit.
    PfamiPF00432. Prenyltrans. 2 hits.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0G172-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDNINKEST TTTTTIDHTT NLLIDKHVEY IVKLGSKKDS FEYWVTEHIR    50
    MNGMYWGLSS LYLLKSLDKL DKNEVIQWLL SCQKSNGGFG GNTSHDDHLL 100
    STLSAVQILI QYDALDKIDI NSVVDYVVKL QREDGSFVGD QWGEVDTRFS 150
    YAAIMCLSLL KSLDKINCEK AVEYILSCQN FDGGFGSIPG AESHAGQIFT 200
    CVGALSILNE INKIDIDKLG WWLSERQLPN GGLNGRPEKS SDVCYSWWVL 250
    SALSAIDRLH WIDNDKLKSY ILKCQDNETG GIADKPGDIP DVFHTFFGIC 300
    GLSLMGYFKD QIESIDPVYA LGTKTLQKLG LNLPWNKNL 339
    Length:339
    Mass (Da):38,012
    Last modified:March 18, 2008 - v1
    Checksum:iC5741A1FB950F662
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000164 Genomic DNA. Translation: EDR41036.1.
    RefSeqiXP_001733035.1. XM_001732983.1.

    Genome annotation databases

    EnsemblProtistsiDDB0233949; DDB0233949; DDB_G0290671.
    GeneIDi8627741.
    KEGGiddi:DDB_G0290671.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000164 Genomic DNA. Translation: EDR41036.1 .
    RefSeqi XP_001733035.1. XM_001732983.1.

    3D structure databases

    ProteinModelPortali B0G172.
    SMRi B0G172. Positions 18-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0219584.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0233949 ; DDB0233949 ; DDB_G0290671 .
    GeneIDi 8627741.
    KEGGi ddi:DDB_G0290671.

    Organism-specific databases

    dictyBasei DDB_G0290671. rabggtb.

    Phylogenomic databases

    eggNOGi COG5029.
    KOi K05956.
    OMAi ESHAGLI.
    PhylomeDBi B0G172.

    Miscellaneous databases

    PROi B0G172.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    InterProi IPR001330. Prenyltrans.
    IPR026873. Ptb1.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    PANTHERi PTHR11774:SF9. PTHR11774:SF9. 1 hit.
    Pfami PF00432. Prenyltrans. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiPGTB2_DICDI
    AccessioniPrimary (citable) accession number: B0G172
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3