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Reviewed, UniProtKB/Swiss-Prot B0G172 (PGTB2_DICDI)

Last modified September 22, 2009. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Probable geranylgeranyl transferase type-2 subunit beta
    EC=2.5.1.60
Alternative name(s):
    Geranylgeranyl transferase type II subunit beta
      Short name=GGTase-II-beta
    Type II protein geranyl-geranyltransferase subunit beta
    Rab geranylgeranyltransferase subunit beta
    Rab geranyl-geranyltransferase subunit beta
      Short name=Rab GG transferase beta
      Short name=Rab GGTase beta
Gene names
Name: rabggtb
ORF Names: DDB_G0290671
OrganismDictyostelium discoideum (Slime mold) [Complete proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal By similarity.

Catalytic activity

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactor

Binds 1 zinc ion per dimer By similarity.

Subunit structure

Heterodimer of an alpha and a beta subunit By similarity.

Sequence similarities

Belongs to the protein prenyltransferase subunit beta family.

Contains 6 PFTB repeats.

Ontologies

Keywords
   DomainRepeat
   LigandMetal-binding
Zinc
   Molecular functionPrenyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionRab geranylgeranyltransferase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Probable geranylgeranyl transferase type-2 subunit beta
PRO_0000331291

Regions

Repeat24 – 6542PFTB 1
Repeat72 – 11342PFTB 2
Repeat120 – 16142PFTB 3
Repeat168 – 20942PFTB 4
Repeat216 – 25742PFTB 5
Repeat264 – 30643PFTB 6
Compositional bias10 – 156Poly-Thr

Sites

Metal binding2421Zinc By similarity
Metal binding2441Zinc By similarity
Metal binding2941Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
B0G172-1 [UniParc].

Last modified March 18, 2008. Version 1.
Checksum: C5741A1FB950F662

FASTA33938,012
        10         20         30         40         50         60 
MTDNINKEST TTTTTIDHTT NLLIDKHVEY IVKLGSKKDS FEYWVTEHIR MNGMYWGLSS 

        70         80         90        100        110        120 
LYLLKSLDKL DKNEVIQWLL SCQKSNGGFG GNTSHDDHLL STLSAVQILI QYDALDKIDI 

       130        140        150        160        170        180 
NSVVDYVVKL QREDGSFVGD QWGEVDTRFS YAAIMCLSLL KSLDKINCEK AVEYILSCQN 

       190        200        210        220        230        240 
FDGGFGSIPG AESHAGQIFT CVGALSILNE INKIDIDKLG WWLSERQLPN GGLNGRPEKS 

       250        260        270        280        290        300 
SDVCYSWWVL SALSAIDRLH WIDNDKLKSY ILKCQDNETG GIADKPGDIP DVFHTFFGIC 

       310        320        330 
GLSLMGYFKD QIESIDPVYA LGTKTLQKLG LNLPWNKNL 

« Hide

Cross-references

Sequence databases

AAFI02000164 Genomic DNA. Translation: EDR41036.1.
RefSeqXP_001733035.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB0G172.

Genome annotation databases

GeneID5860658.
GenomeReviewsGene locus rabggtb in contig CM000154_GR.
KEGGddi:DDB_0233949.

Organism-specific databases

dictyBaseDDB_G0290671. rabggtb.

Family and domain databases

InterProIPR001330. Prenyltrans.
[Graphical view]
PfamPF00432. Prenyltrans. 5 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGTB2_DICDI
AccessionPrimary (citable) accession number: B0G172
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 18, 2008
Last modified: September 22, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents