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Protein

Probable polyketide synthase 28

Gene

pks28

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable polyketide synthase.By similarity

Miscellaneous

Encoded by one of the numerous copies of polyketide synthase genes and clustered as a pair pks27/pks28 in chromosome 5.

Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei187For beta-ketoacyl synthase activityPROSITE-ProRule annotation1
Active sitei661For acyl/malonyl transferase activityPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-DDI-163765 ChREBP activates metabolic gene expression
R-DDI-199220 Vitamin B5 (pantothenate) metabolism
R-DDI-75105 Fatty acyl-CoA biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable polyketide synthase 28 (EC:2.3.1.-)
Short name:
dipks28
Gene namesi
Name:pks28
ORF Names:DDB_G0290469
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290469 pks28

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003694191 – 2690Probable polyketide synthase 28Add BLAST2690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2631O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDbiB0G170
PRIDEiB0G170

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0235222

Structurei

3D structure databases

ProteinModelPortaliB0G170
SMRiB0G170
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2594 – 2671CarrierPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 221Beta-ketoacyl synthaseAdd BLAST54
Regioni651 – 684Acyl/malonyl transferasesAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili906 – 934Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi348 – 351Poly-Asn4
Compositional biasi913 – 946Poly-AsnAdd BLAST34
Compositional biasi1409 – 1428Poly-AsnAdd BLAST20
Compositional biasi1717 – 1774Asn-richAdd BLAST58
Compositional biasi1866 – 1869Poly-Ser4
Compositional biasi2297 – 2302Poly-Asn6
Compositional biasi2682 – 2689Poly-Asn8

Domaini

Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1202 Eukaryota
COG3321 LUCA
InParanoidiB0G170
OMAiGCINAAM
PhylomeDBiB0G170

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR013217 Methyltransf_12
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR009081 PP-bd_ACP
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF08242 Methyltransf_12, 1 hit
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 2 hits
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit

Sequencei

Sequence statusi: Complete.

B0G170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYDIYYNS NEEYYGDVAV IGIGLRFPSG DLNESISKPN QLFNSLLNGL
60 70 80 90 100
NGIVTTSERW SDNYYLNGEI NSVSAGLLPL DEWKRFDPIF FGINPSYDNV
110 120 130 140 150
VTIDPQQRLL LKCVWEALED SGIDPISLRG TNTSTFIGSS TTDYGSLQKS
160 170 180 190 200
PFETQNNIFG SSNHSVANRI GYNFDFRGEN FTIDSACSSS LNAINCGYNS
210 220 230 240 250
IKSNKSNVSV VGGVNFILDP HVSKSFTQLN MLSPTGKCHS FSSDADGFVR
260 270 280 290 300
SEGVGIVILK KLKDAIKDSN NIYCVIKGSS SNVDGNYDKL NFYSPSKSSQ
310 320 330 340 350
YENMKLAIKS TNGQINESDI DYCEAHGTGT PTGDPIELEG ISRLFDQNNN
360 370 380 390 400
NKKQVLVGSI KSNIGHTEAC SGVASLIKCC IMFKNKLFLQ NINFKESNPL
410 420 430 440 450
INFKEWALKV VTEPITFNEN KTTVMLINNF GVTGSNVCLI LSEFKDKRYS
460 470 480 490 500
NDESSSDNFC EQIDIDSKAN EKKKFLIPLS SNSSTSLDNY KSIIVNNNDD
510 520 530 540 550
DSNSSTRSFQ EFVYNQIKFK STSLIQKSVI IASDWNEFQD DDNQIKLKNS
560 570 580 590 600
ESLISNITVE KKKSPLTVIV FCGQGSQYNR MALSLYENEP IFRESVNRFD
610 620 630 640 650
KELFKYYGYS VLDRLRSVSD KDEISIHLPI LAQPANIMIQ ISLYELYKHW
660 670 680 690 700
GVSADIIVGH SLGELSSSYS SGMIDFETLC HLIYHRSLAQ NKTTGTGRAL
710 720 730 740 750
SVNISYDEFI ERYQSKNNKY ETLEIACYNS PTSIVIAGKE DLLNEISKEF
760 770 780 790 800
KSNDIFCAML GSLSSFHTSS QLMIKDEVCS LVFKSKLPSV PVFSTVTTNL
810 820 830 840 850
FNDQTPYNAN YVWENIRQPV SFTQTISNLY KHIESNDMGN EITFIEVAPH
860 870 880 890 900
PTLQFYLNQM KSTQSSYFNN GKSVTIYSPL HKKKNDYNEF LKTISLLYVN
910 920 930 940 950
NNFNINFKSQ LTNINNNNNN INNNNNNNNN NNNNNNNNNN NNNNNNKIIQ
960 970 980 990 1000
FNINSLPLYQ WDDNEYFKLN PFHEKITNEG PSIQNLGNGI DSACPTYQTF
1010 1020 1030 1040 1050
IDIKKPPFQW LKGHQVSDKF YYPGMGYVQN LLSIYPNQDI TISSLEFKSP
1060 1070 1080 1090 1100
LVLTEGNNQC LETTVSLLSK NEFNVKSHYK DQKTNQWILS SLGNFSLFKH
1110 1120 1130 1140 1150
NSINSEKLIN IQALKDKCNF TTISKHDFYE SIKIKTNLTY KGLFQGVKEC
1160 1170 1180 1190 1200
SIGNNCSLAV VSLNEINNHT ISNHSTIGRS LFNAATLDSC LHGSLIAVAQ
1210 1220 1230 1240 1250
PVVLDRIEGF KLYSSNIPLS SSLSKDDNDN SNNSLIKELY IFTEEKARTN
1260 1270 1280 1290 1300
YQSFSASVKI ILPNGRLLME ISRVVCSSVS LANPSNTIIC KPPSNEIYTP
1310 1320 1330 1340 1350
YLQPKDSIIN KPQQFKHLYS VDEFIAKEED NQIISTELLL SLFYKHINVR
1360 1370 1380 1390 1400
CPTINLESLT TLEYNQFKQL YYNNNGLVNE NLFKFVFEIL KSYSSSNHYI
1410 1420 1430 1440 1450
LNHHNNSENK NKNNNNNNNS NNNENSNNES PIHFEKLYNL YTKTTKIIAK
1460 1470 1480 1490 1500
QIFPLKDDSF TDTPQSLFEN GFLDDFYKNS RVVQPLNNLL SEIIIEALKP
1510 1520 1530 1540 1550
ILNQPIVFRI LEAGGGTGSL SLLILEKICK LLNANPNSVI DIEFTWSDVS
1560 1570 1580 1590 1600
SSFSAEIKEK FSPFTAHKNF NIIHRVLDLE KPLFDQDFKT SYYDLVVMSN
1610 1620 1630 1640 1650
VMHVVKKLKP TLDEIHNILT PNGQLLFVEP PYKSINYDSV FCCFSQWWPS
1660 1670 1680 1690 1700
SDSDTELRPD RSCMNQDKWI KILNETNYRD TIISGNDNLI FLIQTRKPSI
1710 1720 1730 1740 1750
NEIISKQSSD SSLDQFNSFN NIILFGNNNY GCSLQNSISS NQELKSKTIN
1760 1770 1780 1790 1800
INNFNEFQTW IANNYDNSDD FDNNKTLIIF LKSIEPINIS NFKEITYEYI
1810 1820 1830 1840 1850
QINQLILKLE LTNNFKHLLI SLDSTTDNYL SSSIIGAARY FVEYPQLDLY
1860 1870 1880 1890 1900
ILNYDIISLK ILNNNSSSSC NSSNGSISSC SCKQQQLSLI NYLINTNNNI
1910 1920 1930 1940 1950
QKEFTINNNK VYYERYTRHS NKIKCNLQSK SFETNKDNLL IQLDSNLEYQ
1960 1970 1980 1990 2000
LYSKRVEPNS KEVEIEIKAT GINYKDYLMH IGMVSSDLDL KYGKEYEVEN
2010 2020 2030 2040 2050
CIGIENPMIG NDFSGIITRL GSDAEKKKFK VGDHVCGVAS KTSGSHVVID
2060 2070 2080 2090 2100
YNFIYHQPLN YNHSISASIP SIYVTSLHSI YGVGNLKSNE SILIHSAAGG
2110 2120 2130 2140 2150
IGISSLDLLK CKKHQGHIFL TVGSKDKEDY LKKNYGSFIT AIYSSRNKDY
2160 2170 2180 2190 2200
VNEIKNKLIE LGEVKQQGVD LILNTLSSEF MDSNFQCLNM SGRIVDLSVT
2210 2220 2230 2240 2250
HLTPNDYIAN NHFKYNMGYN NVEMIDFNGK MVRSYLKKII KMINSNKLEL
2260 2270 2280 2290 2300
SIPIIEYSNN QFKDAIEYIN QRKHIGKIIV NHNQDEFNRV YNNYQQNNNN
2310 2320 2330 2340 2350
NNQIIMKHSY DISKLNMGKN ILLTGQTGII LEIMKYLIRY SNHSIQNIII
2360 2370 2380 2390 2400
LSKSKLKWEL ELLINQTKFI KDNIIKFHFI QIDIEDSNKV NQVLNQLELN
2410 2420 2430 2440 2450
ENITNIDSII HFAFNNDIGD VQDVNMNRLN IAHGAKTIGA INLHNESINR
2460 2470 2480 2490 2500
SWKIKQFIIA SSVSSIFGSD QQCCYVSACS VIDSLSKYRH SLGLPSLAIN
2510 2520 2530 2540 2550
LGTVASTGFI SRNNAIETMF KSSFLKLFSP QLVISSLDLF IQNQRQYPNY
2560 2570 2580 2590 2600
SLVDFNFEVM LTSPNYHLYK LDYEINIFKK SYQINTNSSS GSGSDNEFIH
2610 2620 2630 2640 2650
STILNKISEL LSIDESKINE DLQLTQYGMD SLVIVQLKNF IDNQLGHNLI
2660 2670 2680 2690
TIHQLQHNKI NQSIDIIKFG YLINKNKFKY KNNNKNNNNG
Length:2,690
Mass (Da):305,894
Last modified:March 18, 2008 - v1
Checksum:i938E7F10BAD7C5CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000163 Genomic DNA Translation: EDR41037.1
RefSeqiXP_001733033.1, XM_001732981.1

Genome annotation databases

EnsemblProtistsiEDR41037; EDR41037; DDB_G0290469
GeneIDi8627661
KEGGiddi:DDB_G0290469

Similar proteinsi

Entry informationi

Entry nameiPKS28_DICDI
AccessioniPrimary (citable) accession number: B0G170
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

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