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Protein

Mitochondrial substrate carrier family protein C

Gene

mcfC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi19 – 30121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi55 – 66122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi86 – 97123PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi123 – 134124PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial substrate carrier family protein C
Gene namesi
Name:mcfC
Synonyms:CBP11
ORF Names:DDB_G0287009
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287009. mcfC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 189189Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei190 – 20718Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini208 – 24235Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei243 – 26321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini264 – 28118Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei282 – 30221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini303 – 33028Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei331 – 35121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini352 – 37726Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei378 – 39821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini399 – 44143Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei442 – 46221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini463 – 47210Mitochondrial intermembraneBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Mitochondrial substrate carrier family protein CPRO_0000385519Add
BLAST

Proteomic databases

PaxDbiB0G159.

Expressioni

Inductioni

Down-regulated by phagocytic stimuli.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0237599.

Structurei

3D structure databases

ProteinModelPortaliB0G159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 4136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini42 – 7534EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini73 – 10836EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini110 – 14536EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Repeati184 – 26885Solcar 1Add
BLAST
Repeati276 – 36287Solcar 2Add
BLAST
Repeati375 – 46187Solcar 3Add
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
InParanoidiB0G159.
KOiK14684.
OMAiENDCELT.
PhylomeDBiB0G159.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0G159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLNENDKEF VKKLFDSLDK DNNGKLTREE IKEGFFKLRI PSSEKDIESF
60 70 80 90 100
LTNVDKDKDG SVSFKEFEDF TIENIKKLKI VFEELDTNKS GTLDIHEIEE
110 120 130 140 150
SIKKLNIPLY SEQELIRLFH RIDKNRDNQI DFNEWRELLV LLPNSNLQLI
160 170 180 190 200
ISFWKDSQIL DAGFDNGGFI PPMVEKKEKA SSLRNTITYM LAGSVAGFAS
210 220 230 240 250
RTSTAPLERV KIMCQLNHGK PISLISAFKA CYKDGGIKGF FRGNLANIIK
260 270 280 290 300
VSPESAVKFG TYEYVKKLFA ENDCELTSAQ RFISGSVAGV VSHTTLFPLE
310 320 330 340 350
VVRLRLSAEI AGTYNGIFDC FKKIAISEKS IRPFYRGLGA SITATIPHSG
360 370 380 390 400
VNMMVYEFLK HKVIKMTGNE FPTAGQLLVC ASTSSVCGQL VGYPFHVVKS
410 420 430 440 450
RLITQGSSVN QEKYTGLFDG LTKIIKKEGP IGLYKGIVPS FMKSIPSHSI
460 470
TFIVYEGFKK AFDVNLKEKK HH
Length:472
Mass (Da):53,100
Last modified:March 18, 2008 - v1
Checksum:iE8CBCDBDA2ECAC0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000095 Genomic DNA. Translation: EDR41049.1.
RefSeqiXP_001733022.1. XM_001732970.1.

Genome annotation databases

EnsemblProtistsiDDB0237599; DDB0237599; DDB_G0287009.
GeneIDi8625905.
KEGGiddi:DDB_G0287009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000095 Genomic DNA. Translation: EDR41049.1.
RefSeqiXP_001733022.1. XM_001732970.1.

3D structure databases

ProteinModelPortaliB0G159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0237599.

Proteomic databases

PaxDbiB0G159.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0237599; DDB0237599; DDB_G0287009.
GeneIDi8625905.
KEGGiddi:DDB_G0287009.

Organism-specific databases

dictyBaseiDDB_G0287009. mcfC.

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
InParanoidiB0G159.
KOiK14684.
OMAiENDCELT.
PhylomeDBiB0G159.

Miscellaneous databases

PROiB0G159.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Mitochondrial carrier family: repertoire and peculiarities of the cellular slime mould Dictyostelium discoideum."
    Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G., Klein G.
    Biochimie 89:1058-1069(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  3. "Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium."
    Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B., Skelton J., Ivens A., Bozzaro S.
    BMC Genomics 9:291-291(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMCFC_DICDI
AccessioniPrimary (citable) accession number: B0G159
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: March 18, 2008
Last modified: July 6, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.