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Protein

Mitochondrial substrate carrier family protein C

Gene

mcfC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi19 – 301PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi55 – 662PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi86 – 973PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi123 – 1344PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial substrate carrier family protein C
Gene namesi
Name:mcfC
Synonyms:CBP11
ORF Names:DDB_G0287009
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0287009. mcfC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 189Mitochondrial intermembraneBy similarityAdd BLAST189
Transmembranei190 – 207Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini208 – 242Mitochondrial matrixBy similarityAdd BLAST35
Transmembranei243 – 263Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini264 – 281Mitochondrial intermembraneBy similarityAdd BLAST18
Transmembranei282 – 302Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini303 – 330Mitochondrial matrixBy similarityAdd BLAST28
Transmembranei331 – 351Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini352 – 377Mitochondrial intermembraneBy similarityAdd BLAST26
Transmembranei378 – 398Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini399 – 441Mitochondrial matrixBy similarityAdd BLAST43
Transmembranei442 – 462Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini463 – 472Mitochondrial intermembraneBy similarity10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003855191 – 472Mitochondrial substrate carrier family protein CAdd BLAST472

Proteomic databases

PaxDbiB0G159.

Expressioni

Inductioni

Down-regulated by phagocytic stimuli.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0237599.

Structurei

3D structure databases

ProteinModelPortaliB0G159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 41EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini42 – 75EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini73 – 108EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini110 – 145EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Repeati184 – 268Solcar 1Add BLAST85
Repeati276 – 362Solcar 2Add BLAST87
Repeati375 – 461Solcar 3Add BLAST87

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
InParanoidiB0G159.
KOiK14684.
OMAiENDCELT.
PhylomeDBiB0G159.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0G159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLNENDKEF VKKLFDSLDK DNNGKLTREE IKEGFFKLRI PSSEKDIESF
60 70 80 90 100
LTNVDKDKDG SVSFKEFEDF TIENIKKLKI VFEELDTNKS GTLDIHEIEE
110 120 130 140 150
SIKKLNIPLY SEQELIRLFH RIDKNRDNQI DFNEWRELLV LLPNSNLQLI
160 170 180 190 200
ISFWKDSQIL DAGFDNGGFI PPMVEKKEKA SSLRNTITYM LAGSVAGFAS
210 220 230 240 250
RTSTAPLERV KIMCQLNHGK PISLISAFKA CYKDGGIKGF FRGNLANIIK
260 270 280 290 300
VSPESAVKFG TYEYVKKLFA ENDCELTSAQ RFISGSVAGV VSHTTLFPLE
310 320 330 340 350
VVRLRLSAEI AGTYNGIFDC FKKIAISEKS IRPFYRGLGA SITATIPHSG
360 370 380 390 400
VNMMVYEFLK HKVIKMTGNE FPTAGQLLVC ASTSSVCGQL VGYPFHVVKS
410 420 430 440 450
RLITQGSSVN QEKYTGLFDG LTKIIKKEGP IGLYKGIVPS FMKSIPSHSI
460 470
TFIVYEGFKK AFDVNLKEKK HH
Length:472
Mass (Da):53,100
Last modified:March 18, 2008 - v1
Checksum:iE8CBCDBDA2ECAC0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000095 Genomic DNA. Translation: EDR41049.1.
RefSeqiXP_001733022.1. XM_001732970.1.

Genome annotation databases

EnsemblProtistsiEDR41049; EDR41049; DDB_G0287009.
GeneIDi8625905.
KEGGiddi:DDB_G0287009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000095 Genomic DNA. Translation: EDR41049.1.
RefSeqiXP_001733022.1. XM_001732970.1.

3D structure databases

ProteinModelPortaliB0G159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0237599.

Proteomic databases

PaxDbiB0G159.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEDR41049; EDR41049; DDB_G0287009.
GeneIDi8625905.
KEGGiddi:DDB_G0287009.

Organism-specific databases

dictyBaseiDDB_G0287009. mcfC.

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
InParanoidiB0G159.
KOiK14684.
OMAiENDCELT.
PhylomeDBiB0G159.

Miscellaneous databases

PROiB0G159.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCFC_DICDI
AccessioniPrimary (citable) accession number: B0G159
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: March 18, 2008
Last modified: November 30, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.