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Protein
Submitted name:

Neuregulin 1 isoform ndf43-beta2

Gene

NRG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 1 isoform ndf43-beta2Imported
Gene namesi
Name:NRG1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei239 – 261HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31776.

PTM / Processingi

Proteomic databases

PaxDbiB0FYA9.
PeptideAtlasiB0FYA9.
PRIDEiB0FYA9.

Expressioni

Gene expression databases

GenevisibleiB0FYA9. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349275.

Structurei

3D structure databases

ProteinModelPortaliB0FYA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 127Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST92
Domaini177 – 221EGF-likeInterPro annotationAdd BLAST45

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEU9. Eukaryota.
ENOG4110ST7. LUCA.
HOGENOMiHOG000273863.
HOVERGENiHBG006531.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSiPR01089. NEUREGULIN.
SMARTiSM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B0FYA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SERKEGRGKG KGKKKERGSG KKPESAAGSQ SPALPPRLKE MKSQESAAGS
60 70 80 90 100
KLVLRCETSS EYSSLRFKWF KNGNELNRKN KPQNIKIQKK PGKSELRINK
110 120 130 140 150
ASLADSGEYM CKVISKLGND SASANITIVE SNEIITGMPA STEGAYVSSE
160 170 180 190 200
SPIRISVSTE GANTSSSTST STTGTSHLVK CAEKEKTFCV NGGECFMVKD
210 220 230 240 250
LSNPSRYLCK CPNEFTGDRC QNYVMASFYK AEELYQKRVL TITGICIALL
260 270 280 290 300
VVGIMCVVAY CKTKKQRKKL HDRLRQSLRS ERNNMMNIAN GPHHPNPPPE
310 320 330 340 350
NVQLVNQYVS KNVISSEHIV EREAETSFST SHYTSTAHHS TTVTQTPSHS
360 370 380 390 400
WSNGHTESIL SESHSVIVMS SVENSRHSSP TGGPRGRLNG TGGPRECNSF
410 420 430 440 450
LRHARETPDS YRDSPHSERH NLIAELRRNK AHRSKCMQIQ LSATHLRSSS

IPHLGFIL
Length:458
Mass (Da):50,555
Last modified:February 26, 2008 - v1
Checksum:iF092E3E0F16F9BBB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU363510 mRNA. Translation: ABY66350.1.
RefSeqiNP_001153476.1. NM_001160004.2.
UniGeneiHs.453951.
Hs.668810.

Genome annotation databases

GeneIDi3084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU363510 mRNA. Translation: ABY66350.1.
RefSeqiNP_001153476.1. NM_001160004.2.
UniGeneiHs.453951.
Hs.668810.

3D structure databases

ProteinModelPortaliB0FYA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349275.

Proteomic databases

PaxDbiB0FYA9.
PeptideAtlasiB0FYA9.
PRIDEiB0FYA9.

Protocols and materials databases

DNASUi3084.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3084.

Organism-specific databases

CTDi3084.
PharmGKBiPA31776.

Phylogenomic databases

eggNOGiENOG410IEU9. Eukaryota.
ENOG4110ST7. LUCA.
HOGENOMiHOG000273863.
HOVERGENiHBG006531.

Miscellaneous databases

ChiTaRSiNRG1. human.
GenomeRNAii3084.

Gene expression databases

GenevisibleiB0FYA9. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSiPR01089. NEUREGULIN.
SMARTiSM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB0FYA9_HUMAN
AccessioniPrimary (citable) accession number: B0FYA9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.