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Protein
Submitted name:

Heregulin-beta 3 protein isoform

Gene

NRG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Heregulin-beta 3 protein isoformImported
Gene namesi
Name:NRG1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi177 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PeptideAtlasiB0FWZ3.
PRIDEiB0FWZ3.

Expressioni

Gene expression databases

GenevisibleiB0FWZ3. HS.

Structurei

3D structure databases

ProteinModelPortaliB0FWZ3.
SMRiB0FWZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 127Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST92
Domaini143 – 187EGF-likeInterPro annotationAdd BLAST45

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG053796.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
PfamiView protein in Pfam
PF07679. I-set. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Fragment.

B0FWZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SERKEGRGKG KGKKKERGSG KKPESAAGSQ SPALPPRLKE MKSQESAAGS
60 70 80 90 100
KLVLRCETSS EYSSLRFKWF KNGNELNRKN KPQNIKIQKK PGKSELRINK
110 120 130 140 150
ASLADSGEYM CKVISKLGND SASANITIVE SNATSTSTTG TSHLVKCAEK
160 170 180 190 200
EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYSTSTP

FLSLPE
Length:206
Mass (Da):22,584
Last modified:February 26, 2008 - v1
Checksum:iA564911EBD44BBBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU359055 mRNA. Translation: ABY70644.1.
RefSeqiNP_001153477.1. NM_001160005.1.
UniGeneiHs.453951.
Hs.668810.

Genome annotation databases

GeneIDi3084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU359055 mRNA. Translation: ABY70644.1.
RefSeqiNP_001153477.1. NM_001160005.1.
UniGeneiHs.453951.
Hs.668810.

3D structure databases

ProteinModelPortaliB0FWZ3.
SMRiB0FWZ3.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB0FWZ3.
PRIDEiB0FWZ3.

Protocols and materials databases

DNASUi3084.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3084.

Organism-specific databases

CTDi3084.

Phylogenomic databases

HOVERGENiHBG053796.

Miscellaneous databases

ChiTaRSiNRG1. human.
GenomeRNAii3084.

Gene expression databases

GenevisibleiB0FWZ3. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
PfamiView protein in Pfam
PF07679. I-set. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB0FWZ3_HUMAN
AccessioniPrimary (citable) accession number: B0FWZ3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 15, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.