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Protein

Cytochrome c oxidase subunit 3

Gene

mt:CoIII

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.Curated

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt:CoIIIBy similarity
Synonyms:COX3Imported
Encoded oniMitochondrionImported
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei42 – 59HelicalSequence analysisAdd BLAST18
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003726851 – 262Cytochrome c oxidase subunit 3Add BLAST262

Proteomic databases

PRIDEiB0FWD1.

Structurei

3D structure databases

ProteinModelPortaliB0FWD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 3 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiB0FWD1.
KOiK02262.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0FWD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTHANHPFH LVDYSPWPLT GAIGAMTTVT GLVQWFHQYD NTLFLLGNII
60 70 80 90 100
TMLTMYQWWR DISREGTFQG LHTIPVTLGL RWGMILFIIS EVFFFISFFW
110 120 130 140 150
AFFHSSLSPT IELGMVWPPI GIEPFNPFQI PLLNTAILLA SGVTVTWAHH
160 170 180 190 200
SLMENNHTQT IQSLFFTVLL GIYFSILQAY EYIEAPFTIA DNVYGSTFFV
210 220 230 240 250
ATGFHGLHVL IGTSFLLICL FRHMNCHFSS SHHFGFEAAA WYWHFVDVVW
260
LFLYISIYWW GN
Length:262
Mass (Da):30,294
Last modified:February 26, 2008 - v1
Checksum:iC5F0BD10437C8101
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU352212 Genomic DNA. Translation: ABY51628.1.
RefSeqiYP_001649167.1. NC_010241.1.

Genome annotation databases

EnsemblMetazoaiAAEL018669-RA; AAEL018669-PA; AAEL018669.
GeneIDi5848248.
KEGGiaag:COX3.
VectorBaseiAAEL018669-RA; AAEL018669-PA; AAEL018669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU352212 Genomic DNA. Translation: ABY51628.1.
RefSeqiYP_001649167.1. NC_010241.1.

3D structure databases

ProteinModelPortaliB0FWD1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB0FWD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAAEL018669-RA; AAEL018669-PA; AAEL018669.
GeneIDi5848248.
KEGGiaag:COX3.
VectorBaseiAAEL018669-RA; AAEL018669-PA; AAEL018669.

Organism-specific databases

CTDi4514.

Phylogenomic databases

InParanoidiB0FWD1.
KOiK02262.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX3_AEDAE
AccessioniPrimary (citable) accession number: B0FWD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.