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Protein

Cytochrome c oxidase subunit 3

Gene

mt:CoIII

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.Curated

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt:CoIIIBy similarity
Synonyms:COX3Imported
Encoded oniMitochondrionImported
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei42 – 59HelicalSequence analysisAdd BLAST18
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003726851 – 262Cytochrome c oxidase subunit 3Add BLAST262

Structurei

3D structure databases

ProteinModelPortaliB0FWD1
SMRiB0FWD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 3 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiB0FWD1

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit

Sequencei

Sequence statusi: Complete.

B0FWD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTHANHPFH LVDYSPWPLT GAIGAMTTVT GLVQWFHQYD NTLFLLGNII
60 70 80 90 100
TMLTMYQWWR DISREGTFQG LHTIPVTLGL RWGMILFIIS EVFFFISFFW
110 120 130 140 150
AFFHSSLSPT IELGMVWPPI GIEPFNPFQI PLLNTAILLA SGVTVTWAHH
160 170 180 190 200
SLMENNHTQT IQSLFFTVLL GIYFSILQAY EYIEAPFTIA DNVYGSTFFV
210 220 230 240 250
ATGFHGLHVL IGTSFLLICL FRHMNCHFSS SHHFGFEAAA WYWHFVDVVW
260
LFLYISIYWW GN
Length:262
Mass (Da):30,294
Last modified:February 26, 2008 - v1
Checksum:iC5F0BD10437C8101
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU352212 Genomic DNA Translation: ABY51628.1
RefSeqiYP_001649167.1, NC_010241.1

Genome annotation databases

EnsemblMetazoaiAAEL018669-RA; AAEL018669-PA; AAEL018669
VectorBaseiAAEL018669-RA; AAEL018669-PA; AAEL018669

Similar proteinsi

Entry informationi

Entry nameiCOX3_AEDAE
AccessioniPrimary (citable) accession number: B0FWD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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