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B0FWD1 (COX3_AEDAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:mt:CoIII
Synonyms:COX3
Encoded onMitochondrion
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti) [Reference proteome]
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Cytochrome c oxidase subunit 3
PRO_0000372685

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane42 – 5918Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane128 – 14821Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane198 – 21821Helical; Potential
Transmembrane240 – 26021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B0FWD1 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: C5F0BD10437C8101

FASTA26230,294
        10         20         30         40         50         60 
MSTHANHPFH LVDYSPWPLT GAIGAMTTVT GLVQWFHQYD NTLFLLGNII TMLTMYQWWR 

        70         80         90        100        110        120 
DISREGTFQG LHTIPVTLGL RWGMILFIIS EVFFFISFFW AFFHSSLSPT IELGMVWPPI 

       130        140        150        160        170        180 
GIEPFNPFQI PLLNTAILLA SGVTVTWAHH SLMENNHTQT IQSLFFTVLL GIYFSILQAY 

       190        200        210        220        230        240 
EYIEAPFTIA DNVYGSTFFV ATGFHGLHVL IGTSFLLICL FRHMNCHFSS SHHFGFEAAA 

       250        260 
WYWHFVDVVW LFLYISIYWW GN 

« Hide

References

[1]"The mitochondrial genome of the Yellow fever mosquito - Aedes aegypti."
Lobo N.F., Lovin D., DeBruyn B., Puiu D., Shumway M., Haas B., Nene V., Severson D.W.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LVPib12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU352212 Genomic DNA. Translation: ABY51628.1.
RefSeqYP_001649167.1. NC_010241.1.

3D structure databases

ProteinModelPortalB0FWD1.
SMRB0FWD1. Positions 3-262.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5848248.
KEGGaag:COX3.

Organism-specific databases

CTD4514.

Phylogenomic databases

KOK02262.
ProtClustDBMTH00155.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_AEDAE
AccessionPrimary (citable) accession number: B0FWD1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families