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B0FWD1

- COX3_AEDAE

UniProt

B0FWD1 - COX3_AEDAE

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Protein

Cytochrome c oxidase subunit 3

Gene

mt:CoIII

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.Curated

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt:CoIIIBy similarity
Synonyms:COX3Imported
Encoded oniMitochondrionImported
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Mitochondrion

Subcellular locationi

Mitochondrion inner membrane By similarityCurated; Multi-pass membrane protein By similarityCurated

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Cytochrome c oxidase subunit 3PRO_0000372685Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB0FWD1.
SMRiB0FWD1. Positions 3-262.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei42 – 5918HelicalSequence AnalysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence AnalysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 3 family.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiB0FWD1.
KOiK02262.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0FWD1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTHANHPFH LVDYSPWPLT GAIGAMTTVT GLVQWFHQYD NTLFLLGNII
60 70 80 90 100
TMLTMYQWWR DISREGTFQG LHTIPVTLGL RWGMILFIIS EVFFFISFFW
110 120 130 140 150
AFFHSSLSPT IELGMVWPPI GIEPFNPFQI PLLNTAILLA SGVTVTWAHH
160 170 180 190 200
SLMENNHTQT IQSLFFTVLL GIYFSILQAY EYIEAPFTIA DNVYGSTFFV
210 220 230 240 250
ATGFHGLHVL IGTSFLLICL FRHMNCHFSS SHHFGFEAAA WYWHFVDVVW
260
LFLYISIYWW GN
Length:262
Mass (Da):30,294
Last modified:February 26, 2008 - v1
Checksum:iC5F0BD10437C8101
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU352212 Genomic DNA. Translation: ABY51628.1.
RefSeqiYP_001649167.1. NC_010241.1.

Genome annotation databases

GeneIDi5848248.
KEGGiaag:COX3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU352212 Genomic DNA. Translation: ABY51628.1 .
RefSeqi YP_001649167.1. NC_010241.1.

3D structure databases

ProteinModelPortali B0FWD1.
SMRi B0FWD1. Positions 3-262.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5848248.
KEGGi aag:COX3.

Organism-specific databases

CTDi 4514.

Phylogenomic databases

InParanoidi B0FWD1.
KOi K02262.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mitochondrial genome of the Yellow fever mosquito - Aedes aegypti."
    Lobo N.F., Lovin D., DeBruyn B., Puiu D., Shumway M., Haas B., Nene V., Severson D.W.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12Imported.

Entry informationi

Entry nameiCOX3_AEDAE
AccessioniPrimary (citable) accession number: B0FWD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3